anti-Caspase 8 Antibodies

Protein Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Alternative names and synonyms associated with Caspase 8 (CASP8)

• caspase 8 L homeolog (casp8.L) antibody
• death related ced-3/Nedd2-like protein (LOC661095) antibody
• caspase 8 (CASP8) antibody
• caspase-8 (LOC5563818) antibody
• caspase-8 (casp8) antibody
• Show all gene names
• caspase-8-like (LOC100222284) antibody
• caspase 8 (Casp8) antibody
• caspase 8, apoptosis-related cysteine peptidase (casp8) antibody

• ALPS2B antibody
• CAP4 antibody
• Casp-8 antibody
• CASP8 antibody
• casp8-A antibody
• Show all synonym aliases
• caspase-8 antibody
• FLICE antibody
• MACH antibody
• MCH5 antibody
• xCaspase-8 antibody
• zgc:92075 antibody

Protein level used designations for CASP8

caspase-8 , xcaspase 8 , death related ced-3/Nedd2-like protein , GLEAN_14026 , caspase 8, apoptosis-related cysteine peptidase , caspase 8 , caspase-8-like , DEATH effector domain caspase , Fas-linked ICE-like protease , FADD-homologous ICE/CED-3-like protease , FADD-like ICE , ICE-like apoptotic protease 5 , MACH-alpha-1/2/3 protein , MACH-beta-1/2/3/4 protein , MORT1-associated ced-3 homolog , apoptotic cysteine protease , apoptotic protease Mch-5 , caspase 8, apoptosis-related cysteine protease , caspase-8a , cysteine protease