Browse our anti-Caspase 8 (CASP8) Antibodies

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (show AMD1 Antibodies)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (show TP53 Antibodies)-overexpressed apoptotic embryos.

2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (show BID Antibodies) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

1. These data demonstrate that caspase-8 functions in synovial antigen-presenting cells to regulate the response to inflammatory stimuli by controlling RIPK3 (show RIPK3 Antibodies) action, and this delicate balance maintains homeostasis within the joint.

2. Results illustrate the temporal and spatial activation of caspase-8 and -3 in microglia/macrophages occurring upon ischemic stroke and suggest that the expression of these caspases could be used in neuropathological diagnostic work.

3. inhibition of TAK1 (show NR2C2 Antibodies) triggered two caspase 8 activation pathways through the induction of RIP1 (show RALBP1 Antibodies)-FADD (show FADD Antibodies)-caspase 8 complex as well as FLIP cleavage/degradation.

4. this study identifies a crucial role for caspase-8 in the development of allergic airway inflammation

5. Prolonged treatment of human PMNs or mice bone marrow derived neutrophils (BMDN) with nitric oxide led to enhanced reactive oxygen species generation, caspase-8/caspase-3 (show CASP3 Antibodies) cleavage, reduced mitochondrial membrane potential and finally cellular apoptosis.

6. caspase-8-dependent apoptosis was linked to hepatocellular carcinoma development.

7. Statistically significant increases in the expression of Fas (show FAS Antibodies) and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (show DAPK1 Antibodies), Traf3 (show TRAF3 Antibodies), Tnsf12, Tnfrsf1A (show TNFRSF1A Antibodies) and Ripk1 (show RIPK1 Antibodies).

8. Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3 (show RIPK3 Antibodies))-mediated necroptosis.

9. we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection

10. Data indicate that NLRC4 (show NLRC4 Antibodies) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (show IL18 Antibodies) release, and implicate Caspase-8 in NLRC4 (show NLRC4 Antibodies) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (show CASP1 Antibodies) and Caspase-8.

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

1. These results indicated that cMyc (show MYC Antibodies) and Fas (show FAS Antibodies) regulated the sensitivity of A549 cells to irradiation by regulating caspase8-mediated Bid (show BID Antibodies) activation and the subsequent association with the mitochondrial pathway of apoptosis.

2. The caspase-8/Bid (show BID Antibodies)/cytochrome c (show CYCS Antibodies) axis links signals from death receptors to mitochondrial reactive oxygen species production.

3. miR (show MLXIP Antibodies)-21 was elevated in osteosarcoma, and overexpression of miR (show MLXIP Antibodies)-21 suppressed apoptosis via targeting caspase 8.

4. Our findings indicate the relationship of SNP CASP8 D302H and breast cancer would not be universal but only be sensitive in some particular European countries.

5. no mutations were detected in the CASP8 gene, but we observed a frequent [32/48 (66.6%)] SNP [rs1045487] in the oral cancer samples.

6. case-control study, including 600 hepatocellular carcinoma (HCC) and 600 HBsAg positive controls without HCC, was conducted to assess the relationship between 11 tagging SNPs in CASP8, CASP10 and CFLAR and HBV-related HCC risk .These results suggest that the CASP8 -652 6N ins/del polymorphism may play a protective role in the development, progression, and survival of HBV-related HCC among the Chinese Han population.

7. High caspase-8 is not significantly associated with adverse breast cancer-specific survival. No associations were observed between caspase-8 and clinicopathological criteria.

8. we found that plumbagin could enhance TRAIL-induced apoptosis in Kasumi-1 cells, and the mechanisms include ROS (show ROS1 Antibodies)-mediated upregulation of DR5 (show TNFRSF10B Antibodies) expression, caspase-8 activation and inhibition of cFLIP (show CFLAR Antibodies) expression

9. this study shows that mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 (show NLRP6 Antibodies) inflammasomes by activation of caspase-8 and BRCC36 (show BRCC3 Antibodies) in dry eye

10. Importantly, the bioinformatics analysis of microarray gene expression data derived from a set of high-grade human gliomas, shows that high Caspase-8 expression levels correlate with a worse prognosis.

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (show CASP3 Antibodies) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9.

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (show STAT1 Antibodies) at Ser (show SIGLEC1 Antibodies)-727 and STAT1 (show STAT1 Antibodies) binding to the caspase-8 promoter in cultured lung endothelial cells.

2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Antibodies), IL-6 (show IL6 Antibodies), IL-12p40, IL-1beta (show IL1B Antibodies), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (show BCL2L1 Antibodies).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

1. Induction of apoptosis through targeted activation of caspase (show CASP3 Antibodies) by tamoxifen (ATTAC(TM)) further expands the repertoire of genetic tools for conditional interrogation of cellular functions.

2. Targeted gene knockdown of TNFRSF1B (show TNFRSF1B Antibodies) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (show CASP2 Antibodies) and P53 (show TP53 Antibodies)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (show CASP3 Antibodies).

3. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.