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anti-Mouse (Murine) Caspase 8 Antibodies:
anti-Rat (Rattus) Caspase 8 Antibodies:
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Gerbil Polyclonal Caspase 8 Primary Antibody for ICC, IHC (fro) - ABIN252118
Lavrik, Golks, Krammer: Caspases: pharmacological manipulation of cell death. in The Journal of clinical investigation 2005
Show all 46 Pubmed References
Human Polyclonal Caspase 8 Primary Antibody for IHC (p), WB - ABIN3044129
Jiang, Li, Zhou, Wang, Zhang, Wang: Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways. in International journal of molecular medicine 2014
Show all 14 Pubmed References
Mouse (Murine) Polyclonal Caspase 8 Primary Antibody for WB - ABIN3042601
Yan, Liang, Zhang, Liu, Bu: Apoptotic induction of lung adenocarcinoma A549 cells infected by recombinant RVG Newcastle disease virus (rL-RVG) in vitro. in Molecular medicine reports 2014
Show all 14 Pubmed References
Human Polyclonal Caspase 8 Primary Antibody for IHC (p), WB - ABIN3044432
Zhan, Hu, Yi, An, Huang: Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. in Molecular medicine reports 2015
Show all 14 Pubmed References
Human Polyclonal Caspase 8 Primary Antibody for WB - ABIN3044361
Shan, Li, Newton, Zhao, Li, Guo: A novel protein extracted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells. in Toxicology letters 2014
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Human Polyclonal Caspase 8 Primary Antibody for IF (cc), IF (p) - ABIN724205
Wu, Tang, Jiang, Li, Jiang, Liu: PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. in Molecular and cellular biochemistry 2011
Show all 11 Pubmed References
Human Monoclonal Caspase 8 Primary Antibody for ICC, IP - ABIN1168996
Scaffidi, Medema, Krammer, Peter: FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. in The Journal of biological chemistry 1997
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Human Monoclonal Caspase 8 Primary Antibody for CyTOF, FACS - ABIN252488
Berges, Fuchs, Opelz, Daniel, Naujokat: Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms. in Molecular immunology 2009
Show all 7 Pubmed References
Human Monoclonal Caspase 8 Primary Antibody for IP, WB - ABIN223019
Scarabelli, Stephanou, Pasini, Comini, Raddino, Knight, Latchman: Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. in Circulation research 2002
Show all 5 Pubmed References
Cow (Bovine) Polyclonal Caspase 8 Primary Antibody for WB - ABIN222878
Peluffo, Stouffer, Tesone: Activity and expression of different members of the caspase family in the rat corpus luteum during pregnancy and postpartum. in American journal of physiology. Endocrinology and metabolism 2007
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Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos.
tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist and Caspases-2 and -8
Casp8 signaling is dispensable to the generation of immunity against herpesvirus infection
Polo-like kinase 1 is recruited into mitotic ripoptosomes, where PLK1's activity is controlled via RIPK1-dependent recruitment and Caspase-8-mediated cleavage, ensuring chromosome stability and faithful chromosome segregation during mitosis.
caspase-8 acts as a regulator of GSDMD-driven cell death.
AIM2 inflammasome activates caspase-1 independent of caspase-8. Caspase-1 and caspase-8 are both upstream of caspase-3 cleavage initiated by AIM2.
Pro-apoptotic caspase-8 has to be present with pro-pyroptotic caspase-11 to support tumor necrosis factor- and interferon-beta-dependent tissue injury first observed in the small intestine and later in spleen and thymus. Combined pyroptotic and apoptotic signaling mediated endotoxemia independently of RIPK1 kinase activity and RIPK3 function.
Results uncover a form of caspase-8-mediated pyroptosis and suggest a hypothesis for the increased sensitivity of humans to Yersinia infection compared with the rodent reservoir.
these results demonstrate that Caspase-8 is essential to prevent Salmonella Typhimurium induced enteritis and to ensure host survival
These data demonstrate that caspase-8 functions in synovial antigen-presenting cells to regulate the response to inflammatory stimuli by controlling RIPK3 action, and this delicate balance maintains homeostasis within the joint.
Results illustrate the temporal and spatial activation of caspase-8 and -3 in microglia/macrophages occurring upon ischemic stroke and suggest that the expression of these caspases could be used in neuropathological diagnostic work.
Caspases and their substrates are key mediators of apoptosis.
inhibition of TAK1 triggered two caspase 8 activation pathways through the induction of RIP1-FADD-caspase 8 complex as well as FLIP cleavage/degradation.
this study identifies a crucial role for caspase-8 in the development of allergic airway inflammation
Prolonged treatment of human PMNs or mice bone marrow derived neutrophils (BMDN) with nitric oxide led to enhanced reactive oxygen species generation, caspase-8/caspase-3 cleavage, reduced mitochondrial membrane potential and finally cellular apoptosis.
caspase-8-dependent apoptosis was linked to hepatocellular carcinoma development.
Statistically significant increases in the expression of Fas and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1, Traf3, Tnsf12, Tnfrsf1A and Ripk1.
Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3)-mediated necroptosis.
we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection
Data indicate that NLRC4 activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 release, and implicate Caspase-8 in NLRC4 inflammasome responses in vivo by generation of doubly deficient in Caspase-1 and Caspase-8.
ING4 might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas-induced apoptosis in a caspase-8-dependent pathway.
studies have uncovered the combined actions of the NLRP3 inflammasome and caspase 8 leading to IL-1beta maturation and the directionality of IL-1beta in driving disease inPstpip2(cmo)mice.
both caspase-8-dependent and -independent apoptotic mechanisms are activated in triple-negative breast cancer cells undergoing sustained endoplasmic reticulum stress.
Evidence was provided within a moderate and representative population showing that caspase-8 rs3834129 was not associated with increased colorectal cancer (CRC) risk in a Taiwanese population.
No significant difference was observed in genotypic or allelic frequencies between control and endometriosis groups for rs13416436 and rs2037815 (CASP8 gene). On the other hand, a significant difference between rs3740286 and rs4064 (FAS gene) was found. Regarding polymorphisms in the FAS gene, a statistically significant difference was found in co-dominant and dominant models.
CASP8 deficiency is a novel cause of very early onset-inflammatory bowel disease associated with lymphocyte dysfunction, impaired inflammasome activation, and defec- tive epithelial cell death responses.
Data show that ionizing radiation (IR) induces apoptosis in THP-1 cells through cas-8-mediated pathways, whereas THP-1-derived macrophages (THP-1-M) are resistant to IR due to impaired casp-8-mediated apoptosis during differentiation and not to a capacity for DSB repair suggesting that the regulation of casp-8-mediated apoptosis during differentiation plays a role in the p53-independent radio-resistance of THP-1-M.
The apoptosis was partially dependent upon caspase-8 concomitant with attenuated NF-kappa B survival signal due to stimulus of TNF-alpha. It suggests that PAK4 as target is a switch between caspase-8 apoptosis and NF-kappa B survival signals induced by TNF-alpha in hepatocarcinoma cells.
The caspase 8 mediated RIPK1 cleavage product has a pro-apoptotic function, and further cleavage of this pro-apoptotic cleavage product by human rhinovirus 3C protease may provide a mechanism by which human rhinovirus limits apoptosis.
results suggest that miR-21 regulates the apoptosis of keloid fibroblasts via targeting FasL, and caspase-8 and the mitochondria-mediated apoptotic signaling pathway is involved in this process.
Caspase-3 and -8 and annexin V may serve as diagnostic markers in Ovarian cancer , also explained that the decrement in control of the S phase in the cell cycle may considered one of the significant factors in the development of ovarian tumors
neither rs13416436 nor rs2037815 associated with pre-eclampsia
High CASP8 expression is associated with Colorectal Cancer.
Sleep duration is associated with plasma caspase-8. Caspase-8 independently predicts diabetes mellitus years before disease onset and modifies the effect of sleep duration on incident diabetes mellitus.
Caspase-8 and Caspase-3 expressions in tumor tissues are novel candidate prognostic markers for colorectal cancer patients
Reactive oxygen species-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cells.
this study is the first report on reduced expression of CASP8 in breast cancer versus adjacent normal tissues.
The polymorphisms of CASP8, rs7608692, and haplotype AGAACAG correlated with neutropenia toxicity. The haplotype GGGGAAA was associated with thrombocytopenia toxicity. We conclude that the polymorphisms of CASP8 contribute to the prognosis of advanced lung adenocarcinoma and influence the quality of life and survival.
These results indicated that cMyc and Fas regulated the sensitivity of A549 cells to irradiation by regulating caspase8-mediated Bid activation and the subsequent association with the mitochondrial pathway of apoptosis.
The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production.
miR-21 was elevated in osteosarcoma, and overexpression of miR-21 suppressed apoptosis via targeting caspase 8.
S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.
Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9.
mmediately after hypoxia C8 and C1 follow a similar pattern of increase while long term this appears to dissociate
induces apoptosis in porcine ovarian follicles
Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 at Ser-727 and STAT1 binding to the caspase-8 promoter in cultured lung endothelial cells.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha, IL-6, IL-12p40, IL-1beta, and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1.
Induction of apoptosis through targeted activation of caspase by tamoxifen (ATTAC(TM)) further expands the repertoire of genetic tools for conditional interrogation of cellular functions.
Targeted gene knockdown of TNFRSF1B in zebrafish embryos results in the induction of a caspase-8, caspase-2 and P53-dependent apoptotic program in endothelial cells that bypasses caspase-3.
These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
, xcaspase 8
, death related ced-3/Nedd2-like protein
, caspase 8, apoptosis-related cysteine peptidase
, caspase 8
, DEATH effector domain caspase
, Fas-linked ICE-like protease
, FADD-homologous ICE/CED-3-like protease
, FADD-like ICE
, ICE-like apoptotic protease 5
, MACH-alpha-1/2/3 protein
, MACH-beta-1/2/3/4 protein
, MORT1-associated ced-3 homolog
, apoptotic cysteine protease
, apoptotic protease Mch-5
, caspase 8, apoptosis-related cysteine protease
, cysteine protease