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Human CYLD Protein expressed in HEK-293 Cells - ABIN2712747
Thein, Tao-Cheng, Li, Bayer, Reese, Dosemeci: CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. in PLoS ONE 2014
theses data show that CYLD regulates the magnitude of ubiquitination of several major effectors of the EGFR (show EGFR Proteins) pathway by assisting the recruitment of the ubiquitin ligase Cbl-b to the activated EGFR (show EGFR Proteins) complex.
Through deceasing the expression of Cylindromatosis (CYLD), a K63-specific DUB and endogenous blocker of NF-kappaB (show NFKB1 Proteins) signaling, miR (show MLXIP Proteins)-130b can in return sustain the persistent activation of NF-kappaB (show NFKB1 Proteins), which may promote the malignant progression of transitional cell carcinoma of bladder.
While previous reports have described CYLD as a regulator of DVL proteins; this data suggests the presence of a more complicated reciprocal regulatory mechanism in CML cell lines.
Thrombin (show F2 Proteins)-mediated MALT1 (show MALT1 Proteins) protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage.
MiR (show MLXIP Proteins)-767 acted as a role of tumor promoter by targeting CYLD in human melanoma.
SPATA2 (show SPATA2 Proteins) has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP (show RNF31 Proteins) and CYLD, thereby enabling recruitment of CYLD to signaling complexes.
The data reveal SPATA2 (show SPATA2 Proteins) as a high-affinity binding partner of CYLD and HOIP (show RNF31 Proteins), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (show NFKB1 Proteins) signaling.
The current investigations identified a subset of HPV-positive HNSCCs with mutations in the genes TRAF3 (show TRAF3 Proteins) (tumor necrosis factor (show TNF Proteins) receptor-associated factor 3) and CYLD (cylindromatosis lysine 63 deubiquitinase). Defects in TRAF3 (show TRAF3 Proteins) and CYLD correlated with the activation of transcriptional factor nuclear factor kappaB, episomal HPV status of tumors, and improved patient survival.
The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.
STAT3 (show STAT3 Proteins) and miR (show MLXIP Proteins)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD pathway.
Findings provide physiological insight into the ciliary role of the CYLD/HDAC6 (show HDAC6 Proteins) axis and suggest a functional interplay between these two proteins in ciliary homeostasis.
TLR4 (show TLR4 Proteins) activates CASPASE-8 (show CASP8 Proteins) to cleave and remove the deubiquitinase cylindromatosis (CYLD) in a TRIF (show RNF138 Proteins)- and RIPK1 (show RIPK1 Proteins)-dependent manner to disable necroptosis in macrophages.
CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 (show NOX4 Proteins) and may play a role in vascular remodeling.
this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
Deubiquitinase CYLD negatively regulates MyD88 (show MYD88 Proteins)-mediated signaling by directly interacting with MyD88 (show MYD88 Proteins) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (show MYD88 Proteins) at lysine 231.
CYLD interrupts the ERK (show EPHB2 Proteins)- and p38 (show CRK Proteins)-/AP-1 (show JUN Proteins) and c-Myc (show MYC Proteins) pathways to suppress Nrf2 (show NFE2L2 Proteins)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.
Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.
The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (show DNMT1 Proteins)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (show DNMT1 Proteins)-linked chains are presented.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin specific peptidase like 2
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, retinitis pigmentosa 1 homolog