Browse our anti-DFFA (DFFA) Antibodies

Human DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) interaction partners

1. Glandular, menopause-independent DFF40, DFF45, and Bcl-2 overexpression may play an important role in the pathogenesis of endometrial polyps and benign endometrial hyperplasia

2. evaluate the relative expression levels of miR-196a2 and three of its selected apoptosis-related targets; ANXA1, DFFA and PDCD4 in a sample of GI cancer patients

3. Data show that the caspase-activated DNase (CAD) is activated when caspases cleave its endogenous inhibitor ICAD, resulting in the characteristic DNA laddering of apoptosis.

4. Data suggest that DFF45 gene silencing, when applied in combination with doxorubicin, may offer a therapeutic strategy for the treatment of breast cancer.

5. ICAD deficiency was associated with severe genomic instability.

6. mRNA splicing is actively driven toward the pro-apoptotic isoforms of Bim, Bcl-x, and ICAD in Pnn-depleted MCF-7 cells.

7. The DFF45 level in human endometrium corresponds to the respective phase of the menstrual cycle and decreases significantly after menopause.

8. study reveals a previously unrecognized function of miR-145 in DFF45 processing, which may underlie crucial aspects of cancer biology

9. The heterodimer, DFF40-DFF45, is localized to the chromatin fraction under apoptotic as well as non-apoptotic conditions.

10. DFF45 at chromosome 1 reveal rare allelic variants in neuroblastoma tumors

11. NMR solution structure of the C-terminal domain of DFF45, which is essential for its chaperone-like activity

12. Hypoxia-induced cleavage of caspase-3 and DFF45/ICAD in human failed cardiomyocytes.

13. subunit structures and stoichiometries in human cells before and after induction of apoptosis

14. Hepatitis C virus core protein increases a steady-state level of ICAD protein, possibly through enhancing its promoter activity

15. apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression

16. plays an important and P53-independent role in maintaining chromosome stability and suppressing tumor development

17. demonstrate the cellular mechanisms of neuronal cell degeneration induced via c-Jun-N-terminal kinases and caspase-dependent signaling

18. C-terminal region of each subunit, DFF40 (RLKRK) and DFF45 (KRAR), is essential for nuclear accumulation of the DFF complex.

19. Interestingly, nuclear DNA fragmentation occurred and consistently DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) was cleaved inside the cell as well as in vitro, suggesting a role of caspase-2 in nuclear DNA fragmentation.

20. The highest level of DFF45 endometrial expression was found during the early secretory cycle phase, and significantly lower DFF45 expression was found in the endometrium during the mid-secretory as compared to the early secretory cycle phase.

Mouse (Murine) DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) interaction partners

1. Co-transfection of mouse DFF45(-/-) fibroblasts with plasmids encoding human DFF40 and DFF45 reversed the apoptosis resistance normally observed in these cells

2. a lack of DFF45 facilitates hippocampus-dependent nonspatial memory, as well as hippocampus-dependent spatial memory

3. apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression