118 DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) Antibodies from 25 manufacturers are available on www.antibodies-online.com.
DFFA Antigen Profile
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alternative names and synonyms associated with DFFA
DNA fragmentation factor subunit alpha (DFFA) antibody
DNA fragmentation factor, alpha subunit (Dffa) antibody
DNA fragmentation factor, 45kDa, alpha polypeptide (dffa) antibody
DNA fragmentation factor subunit alpha (Dffa) antibody
DNA fragmentation factor, alpha polypeptide (dffa) antibody
Protein level used designations for DFFA
, DNA fragmentation factor 45 kDa subunit
, DNA fragmentation factor subunit alpha
, inhibitor of CAD
, DNA fragmentation factor, 45kDa, alpha polypeptide