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anti-Human DFFA Antibodies:
anti-Mouse (Murine) DFFA Antibodies:
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Human Polyclonal DFFA Primary Antibody for WB - ABIN540360
Sakahira, Enari, Nagata: Functional differences of two forms of the inhibitor of caspase-activated DNase, ICAD-L, and ICAD-S. in The Journal of biological chemistry 1999
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Human Monoclonal DFFA Primary Antibody for IP, ELISA - ABIN534404
Fukushima, Kikuchi, Koshiba, Kigawa, Kuroda, Yokoyama: Solution structure of the DFF-C domain of DFF45/ICAD. A structural basis for the regulation of apoptotic DNA fragmentation. in Journal of molecular biology 2002
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Human Monoclonal DFFA Primary Antibody for IP, ELISA - ABIN534403
Charrier, Jarry, Toquet, Bou-Hanna, Chedorge, Denis, Vallette, Laboisse: Growth phase-dependent expression of ICAD-L/DFF45 modulates the pattern of apoptosis in human colonic cancer cells. in Cancer research 2002
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Mouse (Murine) Polyclonal DFFA Primary Antibody for WB - ABIN222902
Boulares, Zoltoski, Yakovlev, Xu, Smulson: Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis. in The Journal of biological chemistry 2001
Human Polyclonal DFFA Primary Antibody for ELISA, ICC - ABIN4305087
Nagata, Kishi, Liu, Matsuda, Imanaka, Tsukada, Kang, Muraguchi: The regulation of DNAse activities in subcellular compartments of activated thymocytes. in Immunology 2002
Human Polyclonal DFFA Primary Antibody for IF, IHC - ABIN6712569
Chen, Liu, Yuan, Cao, Qin, Cao, Bian, Wang, Jiang: Methylated actinomycin D, a novel actinomycin D analog induces apoptosis in HepG2 cells through Fas- and mitochondria-mediated pathways. in Molecular carcinogenesis 2014
Glandular, menopause-independent DFF40, DFF45, and Bcl-2 overexpression may play an important role in the pathogenesis of endometrial polyps and benign endometrial hyperplasia
evaluate the relative expression levels of miR-196a2 and three of its selected apoptosis-related targets; ANXA1, DFFA and PDCD4 in a sample of GI cancer patients
Data show that the caspase-activated DNase (CAD) is activated when caspases cleave its endogenous inhibitor ICAD, resulting in the characteristic DNA laddering of apoptosis.
Data suggest that DFF45 gene silencing, when applied in combination with doxorubicin, may offer a therapeutic strategy for the treatment of breast cancer.
ICAD deficiency was associated with severe genomic instability.
mRNA splicing is actively driven toward the pro-apoptotic isoforms of Bim, Bcl-x, and ICAD in Pnn-depleted MCF-7 cells.
The DFF45 level in human endometrium corresponds to the respective phase of the menstrual cycle and decreases significantly after menopause.
study reveals a previously unrecognized function of miR-145 in DFF45 processing, which may underlie crucial aspects of cancer biology
The heterodimer, DFF40-DFF45, is localized to the chromatin fraction under apoptotic as well as non-apoptotic conditions.
DFF45 at chromosome 1 reveal rare allelic variants in neuroblastoma tumors
NMR solution structure of the C-terminal domain of DFF45, which is essential for its chaperone-like activity
Hypoxia-induced cleavage of caspase-3 and DFF45/ICAD in human failed cardiomyocytes.
subunit structures and stoichiometries in human cells before and after induction of apoptosis
Hepatitis C virus core protein increases a steady-state level of ICAD protein, possibly through enhancing its promoter activity
apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression
plays an important and P53-independent role in maintaining chromosome stability and suppressing tumor development
demonstrate the cellular mechanisms of neuronal cell degeneration induced via c-Jun-N-terminal kinases and caspase-dependent signaling
C-terminal region of each subunit, DFF40 (RLKRK) and DFF45 (KRAR), is essential for nuclear accumulation of the DFF complex.
Interestingly, nuclear DNA fragmentation occurred and consistently DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) was cleaved inside the cell as well as in vitro, suggesting a role of caspase-2 in nuclear DNA fragmentation.
The highest level of DFF45 endometrial expression was found during the early secretory cycle phase, and significantly lower DFF45 expression was found in the endometrium during the mid-secretory as compared to the early secretory cycle phase.
Co-transfection of mouse DFF45(-/-) fibroblasts with plasmids encoding human DFF40 and DFF45 reversed the apoptosis resistance normally observed in these cells
a lack of DFF45 facilitates hippocampus-dependent nonspatial memory, as well as hippocampus-dependent spatial memory
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, DNA fragmentation factor 45 kDa subunit
, DNA fragmentation factor subunit alpha
, inhibitor of CAD
, DNA fragmentation factor, 45kDa, alpha polypeptide