Browse our anti-DFFA (DFFA) Antibodies

Full name:: anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide Antibodies (DFFA)

On www.antibodies-online.com are 228 DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) Antibodies from 30 different suppliers available. Additionally we are shipping DFFA Proteins (15) and DFFA Kits (1) and many more products for this protein. A total of 265 DFFA products are currently listed.

Synonyms:: A330085O09Rik, DFF-45, DFF1, DFF35, Dff45, DFFA, ICAD, ICAD-L, ICAD-S, zgc:92229

list all antibodies	Gene Name	GeneID	UniProt
	DFFA	1676	O00273
	DFFA	13347	O54786
	DFFA	114214
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Most Popular Reactivities for anti-DFFA (DFFA) Antibodies

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anti-Rat (Rattus) DFFA Antibodies:

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Top referenced anti-DFFA Antibodies

Human Monoclonal DFFA Primary Antibody for IF, WB - ABIN968331 : Fulda, Meyer, Debatin: Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression. in Oncogene 2002 (PubMed)
Show all 5 Pubmed References
Mouse (Murine) Polyclonal DFFA Primary Antibody for WB - ABIN967295 : Enari, Sakahira, Yokoyama, Okawa, Iwamatsu, Nagata: A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. in Nature 1998 (PubMed)
Show all 4 Pubmed References
Mouse (Murine) Polyclonal DFFA Primary Antibody for WB - ABIN222902 : Boulares, Zoltoski, Yakovlev, Xu, Smulson: Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis. in The Journal of biological chemistry 2001 (PubMed)
Human Polyclonal DFFA Primary Antibody for ELISA, ICC - ABIN4305087 : Nagata, Kishi, Liu, Matsuda, Imanaka, Tsukada, Kang, Muraguchi: The regulation of DNAse activities in subcellular compartments of activated thymocytes. in Immunology 2002 (PubMed)

More Antibodies against DFFA Interaction Partners

Human DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) interaction partners

evaluate the relative expression levels of miR (show MLXIP Antibodies)-196a2 and three of its selected apoptosis-related targets; ANXA1 (show ANXA1 Antibodies), DFFA and PDCD4 (show PDCD4 Antibodies) in a sample of GI cancer patients
Data show that the caspase-activated DNase (CAD (show DFFB Antibodies)) is activated when caspases cleave its endogenous inhibitor ICAD, resulting in the characteristic DNA laddering of apoptosis.
Data suggest that DFF45 gene silencing, when applied in combination with doxorubicin, may offer a therapeutic strategy for the treatment of breast cancer.
ICAD deficiency was associated with severe genomic instability.
mRNA splicing is actively driven toward the pro-apoptotic isoforms of Bim (show BCL2L11 Antibodies), Bcl-x (show BCL2L1 Antibodies), and ICAD in Pnn (show PNN Antibodies)-depleted MCF-7 cells.
The DFF45 level in human endometrium corresponds to the respective phase of the menstrual cycle and decreases significantly after menopause.
study reveals a previously unrecognized function of miR (show MLXIP Antibodies)-145 in DFF45 processing, which may underlie crucial aspects of cancer biology
The heterodimer, DFF40 (show DFFB Antibodies)-DFF45, is localized to the chromatin fraction under apoptotic as well as non-apoptotic conditions.
DFF45 at chromosome 1 reveal rare allelic variants in neuroblastoma (show ARHGEF16 Antibodies) tumors
NMR solution structure of the C-terminal domain of DFF45, which is essential for its chaperone-like activity

Mouse (Murine) DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) interaction partners

Co-transfection of mouse DFF45(-/-) fibroblasts with plasmids encoding human DFF40 (show DFFB Antibodies) and DFF45 reversed the apoptosis resistance normally observed in these cells
a lack of DFF45 facilitates hippocampus-dependent nonspatial memory, as well as hippocampus-dependent spatial memory
apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression

DFFA Antigen Profile

Antigen Summary

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative names and synonyms associated with DFFA

DNA fragmentation factor subunit alpha (DFFA) antibody
DNA fragmentation factor, alpha subunit (Dffa) antibody
DNA fragmentation factor, 45kDa, alpha polypeptide (dffa) antibody
DNA fragmentation factor subunit alpha (Dffa) antibody
DNA fragmentation factor, alpha polypeptide (dffa) antibody

A330085O09Rik antibody
DFF-45 antibody
DFF1 antibody
DFF35 antibody
Dff45 antibody
DFFA antibody
ICAD antibody
ICAD-L antibody
ICAD-S antibody
zgc:92229 antibody

Protein level used designations for DFFA

DFF45 , DNA fragmentation factor 45 kDa subunit , DNA fragmentation factor subunit alpha , inhibitor of CAD , DFF-45 , DNA fragmentation factor, 45kDa, alpha polypeptide

GENE ID	SPECIES
1676	Homo sapiens
13347	Mus musculus
487449	Canis lupus familiaris
419451	Gallus gallus
457928	Pan troglodytes
507981	Bos taurus
548407	Xenopus (Silurana) tropicalis
713544	Macaca mulatta
100173283	Pongo abelii
114214	Rattus norvegicus
100719233	Cavia porcellus
436904	Danio rerio

Selected quality suppliers for anti-DFFA (DFFA) Antibodies

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Show all anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) Antibodies with Pubmed References

Human DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) interaction partners

Mouse (Murine) DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) interaction partners

Antigen Summary

Alternative names and synonyms associated with DFFA

Protein level used designations for DFFA