Browse our anti-PARP1 (PARP1) Antibodies

Full name:: anti-Poly (ADP-Ribose) Polymerase 1 Antibodies (PARP1)

On www.antibodies-online.com are 422 Poly (ADP-Ribose) Polymerase 1 (PARP1) Antibodies from 27 different suppliers available. Additionally we are shipping PARP1 Kits (40) and PARP1 Proteins (28) and many more products for this protein. A total of 518 PARP1 products are currently listed.

Synonyms:: 5830444G22Rik, Adprp, Adprt, adprt1, ADPRT 1, AI893648, ARTD1, BEST:LD21673, C80510, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\\CG40411, dPARP, LD21673.3prime, padprt-1, parp, parp-1, PARP1, ppol, si:dkey-206f10.3, sPARP-1, wu:fc60f12, zgc:110092

list all antibodies	Gene Name	GeneID	UniProt
	PARP1	142	P09874
	PARP1	25591	P27008
	PARP1	11545
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Most Popular Reactivities for anti-PARP1 (PARP1) Antibodies

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anti-Human PARP1 Antibodies:

anti-Rat (Rattus) PARP1 Antibodies:

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Top referenced anti-PARP1 Antibodies

Human Monoclonal PARP1 Primary Antibody for IF, ELISA - ABIN559798 : Crawford, Yang, Mattaini, Hunter: The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. in The Journal of biological chemistry 2009 (PubMed)
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Human Monoclonal PARP1 Primary Antibody for FACS, WB - ABIN531998 : Ko, Shen, Chen: Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species. in Free radical biology & medicine 2004 (PubMed)
Show all 5 Pubmed References
Human Polyclonal PARP1 Primary Antibody for ChIP, WB - ABIN2668274 : Kim, Mauro, Gévry, Lis, Kraus: NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1. in Cell 2004 (PubMed)
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Rat (Rattus) Polyclonal PARP1 Primary Antibody for DB - ABIN1881626 : Beneke, Scherr, Ponath, Popp, Bürkle: Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span. in Mechanisms of ageing and development 2010 (PubMed)
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Human Polyclonal PARP1 Primary Antibody for WB - ABIN1881627 : Dong, Bey, Li, Kabbani, Yan, Xie, Hsieh, Gao, Boothman: Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation. in Cancer research 2010 (PubMed)
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Human Polyclonal PARP1 Primary Antibody for WB - ABIN1881628 : Krishnakumar, Kraus: PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway. in Molecular cell 2010 (PubMed)
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Human Polyclonal PARP1 Primary Antibody for DB - ABIN1881629 : Majewski, Thurston, Ramalingam, Kiela, Ghishan: Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts. in The Journal of biological chemistry 2010 (PubMed)
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Human Polyclonal PARP1 Primary Antibody for DB - ABIN1881631 : Kim, Kang, Lee, Lee, Lee, Choi, Lee, Cho, Jin, Jheon, Son, Lee, Jung, Cha, Kim, Kang, Kam, Jung, Jheon, Park: Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer. in Cancer science 2010 (PubMed)
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Human Polyclonal PARP1 Primary Antibody for IF (p), IHC (p) - ABIN677903 : Ma, Liu, Wang, Liu, Chen, Valle, Zuo, Xia, Liu: Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals. in ACS nano 2015 (PubMed)
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More Antibodies against PARP1 Interaction Partners

Human Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

Our study demonstrates a cross-talk between PARPi and tumor-associated immunosuppression and provides evidence to support the combination of PARPi and PD-L1 (show CD274 Antibodies) or PD-1 (show PDCD1 Antibodies) immune checkpoint blockade as a potential therapeutic approach to treat breast cancer
PARP1 expression was increased in GBM at both mRNA and protein levels. increased PARP1 levels show positive correlation with increasing tumour grades in gliomas Higher PARP1 mRNA expression levels were associated with ATRX (show ATRX Antibodies) and TP53 (show TP53 Antibodies) mutations.
Existence of a kinase-independent role of nuclear RIPK1 (show RIPK1 Antibodies) in the regulation of PARP1.
The observed incomplete sister chromatid disjunction may be due to the accumulation of unreplicated DNA during mitosis in CDA (show CDA Antibodies)-deficient cells, as reflected in the changes in centromeric DNA structure associated with the decrease in basal PARP-1 activity.
Studied role of PARP1 regulation and senescence by melatonin.
Report a requirement for PARP2 (show PARP2 Antibodies) in stabilizing replication forks that encounter base excision repair (BER) intermediates through Fbh1 (show FBXO18 Antibodies)-dependent regulation of Rad51 (show RAD51 Antibodies). Whereas PARP2 (show PARP2 Antibodies) is dispensable for tolerance of cells to single stranded breaks or homologous recombination dysfunction, it is redundant with PARP1 in BER.
Potential high binding affinity compounds that are predicted by molecular simulations were then tested by in vitro methods. Computationally proposed compounds as PARP-1 inhibitors were confirmed by in vitro studies. In vitro results showed that compounds 7111620047 and 7119980926 have IC50 values of 0.56 and 63 muM against PARP-1 target, respectively
The impairment of PARP (show COL11A2 Antibodies)-dependent DNA damage response (DDR (show DDR1 Antibodies)) signaling due to mutations in the FUS (show FUS Antibodies) nuclear localization sequence induces additional cytoplasmic FUS (show FUS Antibodies) mislocalization which in turn results in neurodegeneration and FUS (show FUS Antibodies) aggregate formation in amyotrophic lateral sclerosis.
Septin4 is a novel essential factor involved in oxidative stress induced (show SQSTM1 Antibodies) vascular endothelial cell injury by interacting with apoptosis-related protein PARP1.
Data show that the mRNA level of poly(ADP-ribose) polymerase (PARP)-1 was significantly regulated by miR (show MLXIP Antibodies)-216b.

Mouse (Murine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

PARP-1 mediated microgial responses can directly reduce blood brain barrier integrity by increasing endothelial cell permeability.
A stimulation induced PARP1 binding to phosphorylated Erk2 (show MAPK1 Antibodies) in the chromatin of cerebral neurons caused Erk (show EPHB2 Antibodies)-induced PARP1 activation, rendering transcription factors and promoters of immediate early (show JUN Antibodies) genes (IEG) accessible to PARP1-bound phosphorylated Erk2 (show MAPK1 Antibodies).
The present work identifies several microglial responses to the endogenous alarmin S100B (show S100B Antibodies), including release of the cytotoxic protease MMP9 (show MMP9 Antibodies) and shows that these effects are modulated by PARP-1.
flavonoids of Rosa roxburghii Tratt enhanced radioprotection at least partially by regulating PARP-1/AIF (show AIFM1 Antibodies) to reduce apoptosis.
These data demonstrate the presence of an FAF1 (show FAF1 Antibodies)-PARP1 axis that is involved in oxidative stress-induced (show SQSTM1 Antibodies) necrosis and in the pathology of Parkinson's disease.
Data indicate that poly(ADP-ribose)polymerase 1 (PARP1) D993A/D993A mice and cells are viable and show no obvious abnormalities.
Telomere-internal double-strand breaks (DSBs) are also repaired by a PARP1- and Ligase3-dependent reaction, suggesting alternative non-homologous end-joining (alt-NHEJ), which relies on microhomology at DSBs.
post-translational modification facilitates the mobilization of SIRT6 (show SIRT6 Antibodies) to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1) to DNA break sites and for efficient repair of double-strand break.
Data show that Tp53 (show TP53 Antibodies)- and Atm (show ATM Antibodies)-defective Chronic lymphocytic leukemia (CLL) mimicking the high-risk form of human disease and that Atm (show ATM Antibodies)-deficient CLL is sensitive to PARP1 inhibition.
The results suggest that ATRX (show ATRX Antibodies) is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.

Fruit Fly (Drosophila melanogaster) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process.
A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin (show PARK2 Antibodies) mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin (show PARK2 Antibodies) mutants.
chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (show H2AFV Antibodies) in a nucleosome positioned in promoter regions of PARP-1-dependent genes
Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis
PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss.
Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility.
PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av).
demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements.
PARP-e autoregulates Parp transcription
propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff

Cow (Bovine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

no difference was found in the level of SBDP145 between muscles, while SBDP120 and PARP-1 cleavage products were not detected
ADPRT Val762Ala and APE1 (show APEX1 Antibodies) Asp148Glu polymorphisms are not associated with increased breast cancer risk
analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites
FGF2 (show FGF2 Antibodies) stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK (show MAPK1 Antibodies))-dependent pathway

Pig (Porcine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

The transcript levels of autophagy-related genes and poly(ADP-ribose) polymerase 1 (PARP1), were transiently up-regulated by fertilization, decreased at the late 1-cell stage, and maintained until the blastocyst stage.
The PARP1 signaling pathway is involved in oocyte nest breakdown and primordial follicle formation in fetal and neonatal porcine ovaries, but is different from follicular atresia in adult porcine ovaries that involves cellular apoptosis.
Cleavage of PARP-1 by activated (cleaved) caspase-3 (show CASP3 Antibodies) may serve a key role in controlling follicular atresia through granulosa cell degeneration.

PARP1 Antigen Profile

Antigen Summary

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Alternative names and synonyms associated with PARP1

poly(ADP-ribose) polymerase 1 (PARP1) antibody
poly (ADP-ribose) polymerase 1 (Parp1) antibody
poly (ADP-ribose) polymerase family, member 1 (Parp1) antibody
Poly-(ADP-ribose) polymerase (Parp) antibody
poly(ADP-ribose) polymerase 1 L homeolog (parp1.L) antibody
poly (ADP-ribose) polymerase 1 (PARP1) antibody
poly(ADP-ribose) polymerase 1 (Parp1) antibody
poly (ADP-ribose) polymerase 1 (parp1) antibody

5830444G22Rik antibody
Adprp antibody
Adprt antibody
adprt1 antibody
ADPRT 1 antibody
AI893648 antibody
ARTD1 antibody
BEST:LD21673 antibody
C80510 antibody
CG17685 antibody
CG17696 antibody
CG17718 antibody
CG40411 antibody
D.PARP antibody
Dm.pARTa antibody
Dmel\\CG40411 antibody
dPARP antibody
LD21673.3prime antibody
padprt-1 antibody
parp antibody
parp-1 antibody
PARP1 antibody
ppol antibody
si:dkey-206f10.3 antibody
sPARP-1 antibody
wu:fc60f12 antibody
zgc:110092 antibody

Protein level used designations for PARP1

, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase diphtheria toxin-like 1 NAD(+) ADP-ribosyltransferase 1 poly (ADP-ribose) polymerase family, member 1 poly [ADP-ribose] polymerase 1 poly(ADP-ribose) polymerase poly(ADP-ribose) synthetase poly(ADP-ribosyl)transferase poly[ADP-ribose] synthase 1 ADP-ribosyltransferase (NAD+ ADP-ribosyltransferase 1 ADPRT 1 poly (ADP-ribose) polymerase) poly(ADP-ribose) polymerase PARP-1 poly[ADP-ribose] synthetase 1 ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1 msPARP CG40411-PB CG40411-PC Parp-PB Parp-PC Poly(ADP ribose) polymerase 1 Poly(ADP)-Ribose polymerase Poly(ADP-)Ribose polymerase Poly(ADP-ribose) polymerase Poly(ADP-ribose) polymerase 1 PARP-1 ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase) Poly[ADP-ribose] synthase 1 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1

GENE ID	SPECIES
142	Homo sapiens
25591	Rattus norvegicus
11545	Mus musculus
3355109	Drosophila melanogaster
397928	Xenopus laevis
396199	Gallus gallus
490385	Canis lupus familiaris
286764	Bos taurus
100689463	Cricetulus griseus
100733925	Cavia porcellus
560788	Danio rerio
100058523	Equus caballus
100621034	Sus scrofa

Selected quality suppliers for anti-PARP1 (PARP1) Antibodies

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Show all anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) Antibodies with Pubmed References