Browse our anti-PARP1 (PARP1) Antibodies

Human Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

1. PARP1-LSD1 functional interplay controls transcription of SOD2 that protects human pro-inflammatory macrophages from death under an oxidative condition.

2. Autophagy upregulates the expression of PARP-1 and relieves radiation damage by reducing the generation of ROS.

3. Data suggest poly(ADP-ribose) polymerase-1 (PARP-1) as a critical local feedback regulator of both activation-induced deaminase (AID) activity and DNA repair during Ig gene diversification.

4. The findings uncover a previously unrecognized mechanistic link between MORC2 and PARP1 in the regulation of cellular response to DNA damage.

5. While BRCA1-depleted or -mutated cells were hypersensitive to the clinically approved PARPi olaparib, its toxicity was significantly attenuated by depletion of OGG1 or MYH DNA glycosylases, as well as by treatment with reactive oxygen species scavengers, growth under hypoxic conditions or chemical OGG1 inhibition.

6. It is suggested that PARP1 is a crucial regulator of IRF1-mediated immune response.

7. This new finding highlights the ability of PARP1 to recognize and differentiate the distorted DNA backbone in a biomimetic system caused by different diastereomeric forms of a cdA lesion.

8. A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites.

9. miR-7-5p targets PARP1 to exert its suppressive effects on homologous recombination repair, indicating that the alteration of the expression of miR-7-5p may be a promising strategy for overcoming chemo-resistance in SCLC therapy.

10. our data support DAXX as a modulator of DNA damage repair and suppressor of triple negative breast cancer (TNBC) progression to sensitize tumors to the PARP inhibitor by repressing RAD51 functions. These provide an effective strategy for a better application of PARP inhibition in the treatment of TNBC

11. Poly(ADP-ribosyl)ation by PARP1 in regard to reaction mechanism and regulatory proteins have been discussed. (Review)

12. niraparib is the first PARP inhibitor approved as maintenance therapy for patients with ovarian, fallopian tube, or primary peritoneal cancer, with improvement in PFS, regardless of gBRCAm status

13. Study uncovers a new role of cytoplasmic expression of PARP-1 in regulating DR5-activated apoptosis in pancreatic cancer cells in vitro and the sensitivity of pancreatic tumors to TRA-8 therapy in vivo. These findings highlight cytoplasmic PARP-1 as a potential new marker for pancreatic cancer progression.

14. Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schonlein purpura.

15. Results provide evidence that PARP1 catalytic activity is impaired by MACROD2 haploinsufficiency resulting in increased genomic instability and DNA damage in intestinal neoplasm.

16. downregulation of XRCC1, which interacts with PARP1 and coordinates base excision repair, is an early event in human breast cancer pathogenesis

17. a function for PARP-1 in DNA double-strand breaks resection, is identified.

18. PHF20 interacts with poly(ADP-ribose) polymerase 1 (PARP1) and directly binds to promoter regions of octamer-binding transcription factor 4 (OCT4) and sex determining region Y-box 2 (SOX2) to modulate a histone mark associated with active transcription, trimethylation of lysine 4 on histone H3 protein subunit (H3K4me3).

19. Given the highly important role of PARP1 in DNA repair and cancer intervention, this structure presents an attractive opportunity to explore the therapeutic potential of PARP1 inhibition via G-quadruplex DNA targeting.

20. rs907187 and rs4653734 have remarkable associations with breast cancer risk among Iranian women

Mouse (Murine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

1. The data indicate that PARP1-mediated poly(ADP-ribosyl)ation of FoxO3a plays a key role in cardiomyocyte autophagy.

2. The loss of Artd1 in myeloid cells also reduced the TH1 response to Helicobacter pylori and impaired immune control of the bacteria. Furthermore, Artd1(DeltaMyel) mice failed to control tumor growth in a s.c. MC-38 model of colon cancer, which could be attributed to reduced TH1 and CD8 responses.

3. our results reveal PARP1 and the Ku70/80 complex as critical DNA double-strand breaks (DSBs) sensors, and suggest that PARP1 may function as an important regulator of the Ku70/80 complex at the DSBs in the S/G2 phase.

4. data strongly suggest that PARP-1 inhibition blunts elastase-induced MMP-2 and MMP-9 expression, which may be partly responsible for prevention of emphysema.

5. Rev1 contributes to proper mitochondrial function via the PARP-NAD-SIRT1-PGC1A axis.

6. proteasomal degradation of the PARP-1 DPC is active in mouse fibroblasts and that a model repair intermediate is processed by the BER machinery

7. DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD(+) depletion in experimental atrial fibrillation.

8. PARP-1 played a critical role in hydrogen peroxide-mediated autophagy and both of them were involved in apoptosis of vascular smooth muscle cell.

9. The present results demonstrated that the lack of PARP1 enzyme only disturbed the microbial flora of the duodenum, where the biodiversity increased in the knockout animals on the species level but decreased on the order level.

10. PARP-1, via manipulating the binding of NF-kB/AP-1 at the MMP-9 promoter, regulates MMP-9 expression, which helps maintain mitochondrial homeostasis.

11. PARP1 interacts with HuR, resulting in its PARylation, primarily at site D226. PARP inhibition and the D226 mutation impair HuR's PARylation, nucleocytoplasmic shuttling and mRNA binding.

12. Peripheral T-cell number was not affected in single PARP1-deficient mice. Double-deficiency in PARP-1/PARP-2 in T-cells led to highly aggressive T-cell lymphomas.

13. The dysfunction of PARP1 in esophageal epithelial cells increases the levels of ROS and oxidative DNA damage in Barrett's esophagus.

14. pharmacological inhibition of PARP-1 reversed both particulate matter-induced Abeta increase and glial activation.

15. The functional consequence of Parp1 heterozygosity on BRCA2 loss is demonstrated by a significant increase in tumorigenesis in Brca2 knockout mice.

16. findings reveal PARP-1 as a double-edged sword in colorectal carcinogenesis, which suppresses tumor initiation following DNA alkylation in a MGMT-dependent manner, but promotes inflammation-driven tumor progression.

17. an immunoprecipitation assay indicated that hypoxia triggered activation of the binding activity of Sp1 to the promoters of PARP-1 and caspase-3, which is abrogated by miR-7a/b. In summary, these findings identified miR-7a/b as protectors of cardiac remodeling and hypoxia-induced injury in H9c2 cardiomyoblasts involving Sp1 and PARP-1.

18. PARP-1 mediated microgial responses can directly reduce blood brain barrier integrity by increasing endothelial cell permeability.

19. A stimulation induced PARP1 binding to phosphorylated Erk2 in the chromatin of cerebral neurons caused Erk-induced PARP1 activation, rendering transcription factors and promoters of immediate early genes (IEG) accessible to PARP1-bound phosphorylated Erk2.

20. The present work identifies several microglial responses to the endogenous alarmin S100B, including release of the cytotoxic protease MMP9 and shows that these effects are modulated by PARP-1.

Fruit Fly (Drosophila melanogaster) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

1. The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process.

2. A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin mutants.

3. chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av in a nucleosome positioned in promoter regions of PARP-1-dependent genes

4. Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis

5. PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss.

6. Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility.

7. PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av).

8. inhibits transcription by contributing to the condensation of chromatin, which creates a barrier against gene transcription

9. demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements.

10. PARP-e autoregulates Parp transcription

11. propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff

12. PARP1 is required for protein targeting to Cajal body.

Cow (Bovine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

1. no difference was found in the level of SBDP145 between muscles, while SBDP120 and PARP-1 cleavage products were not detected

2. ADPRT Val762Ala and APE1 Asp148Glu polymorphisms are not associated with increased breast cancer risk

3. analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites

4. FGF2 stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK)-dependent pathway

Pig (Porcine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

1. The transcript levels of autophagy-related genes and poly(ADP-ribose) polymerase 1 (PARP1), were transiently up-regulated by fertilization, decreased at the late 1-cell stage, and maintained until the blastocyst stage.

2. The PARP1 signaling pathway is involved in oocyte nest breakdown and primordial follicle formation in fetal and neonatal porcine ovaries, but is different from follicular atresia in adult porcine ovaries that involves cellular apoptosis.

3. Cleavage of PARP-1 by activated (cleaved) caspase-3 may serve a key role in controlling follicular atresia through granulosa cell degeneration.