PARP1 antibody (AA 183-214)

Catalog No. ABIN3032164

This Rabbit Polyclonal antibody specifically detects PARP1 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for PARP1 antibody (AA 183-214) (ABIN3032164)

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-PARP1 Antibody

Binding Specificity: AA 183-214

Purpose: PARP1 Antibody

Predicted Reactivity: Mouse

Purification: Purified

Immunogen: A portion of amino acids 183-214 from the human protein was used as the immunogen for this PARP antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the PARP antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles

Storage: -20 °C

Storage Comment: Aliquot the PARP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PARP1

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Alternative Name: PARP

Background: PARP is a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Additional PARP1 pathway and chromatin-associated DNA repair studies may benefit from our PARP1 antibody page featuring < a href=../tds/parp-antibody-cfd-16-rq5290>recombinant rabbit monoclonal clone CFD-16 with knockdown-validated target recognition.

UniProt: P09874

Pathways: Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location