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anti-Human YWHAZ Antibodies:
anti-Mouse (Murine) YWHAZ Antibodies:
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Chicken Polyclonal YWHAZ Primary Antibody for EIA, IHC (p) - ABIN318724
Martin, Patel, Jones, Howell, Robinson, Aitken: Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein. in FEBS letters 1993
Show all 2 Pubmed References
Human Polyclonal YWHAZ Primary Antibody for IHC, WB - ABIN965482
Gu, Jin, Choi, Baek, Yeo, Lee: Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. in FEBS letters 2006
Show all 2 Pubmed References
Human Monoclonal YWHAZ Primary Antibody for WB - ABIN1882058
Zupan, Steffens, Berry, Landt, Gross: Cloning and expression of a human 14-3-3 protein mediating phospholipolysis. Identification of an arachidonoyl-enzyme intermediate during catalysis. in The Journal of biological chemistry 1992
Show all 4 Pubmed References
Human Polyclonal YWHAZ Primary Antibody for IF, IHC (p) - ABIN272122
Nagappan, Park, Park, Hong, Yumnam, Lee, Kim, Kim, Lee, Lee, Cho, Lee, Won, Cho, Kim: Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo-/- mice. in Chemico-biological interactions 2013
Human Polyclonal YWHAZ Primary Antibody for FACS, IHC (p) - ABIN652428
Li, Inoki, Yeung, Guan: Regulation of TSC2 by 14-3-3 binding. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
Knockdown of YWHAZ inhibited cell cycle progression, migration, and the expression of stem cell markers and tumorigenicity was suppressed in tumor-bearing BALB/c nude mice. The expression of YWHAZ was directly down-regulated by miR (show MLXIP Antibodies)-30e in resistant ovarian cancer cells.
our data suggest miR (show MLXIP Antibodies)-204 and 14-3-3zeta as potential therapeutic targets in osteosarcoma
evidence is lacking to conclude that 14-3-3zeta is a useful marker of tamoxifen resistance.
TRIM21 (show TRIM21 Antibodies) positively regulated osteosarcoma cell proliferation. Overexpression of TRIM21 (show TRIM21 Antibodies) enhanced osteosarcoma cell tolerance toward various stresses. YWHAZ protein was identified as a novel interacting partner of TRIM21 (show TRIM21 Antibodies) and its expression levels were negatively regulated by TRIM21 (show TRIM21 Antibodies).
several disordered regions of PI4KB (show PI4KB Antibodies) become protected from proteolytical degradation upon 14-3-3 (show YWHAQ Antibodies) binding.
Ectopic expression of miR (show MLXIP Antibodies)-451 could inhibit the cell migration and invasion, promoted apoptosis, induced cell-cycle arrest Furthermore, tyrosine3-monooxygenase/tryptophan5-monooxygenase activation protein zeta (YWHAZ) was identified as a direct target of miR (show MLXIP Antibodies)-451
Serum autoantibodies to YWHAZ are produced at substantially greater levels in gastric cancer patients as compared to controls.
Dimerization of 14-3-3 zeta (14-3-3zeta) dimer was disrupted by a double mutant (L12E, M78K).
Results identified YWHAZ as the direct target of miR (show MLXIP Antibodies)-613 in hepatocellular carcinoma (HCC (show FAM126A Antibodies)). Its overexpression reverses the tumor suppressing role of miR (show MLXIP Antibodies)-613 in HCC (show FAM126A Antibodies) cells.
In AML (show RUNX1 Antibodies) patients, low level of miR (show MLXIP Antibodies)-451 is negatively correlated with high levels of c-Myc (show MYC Antibodies) and YWHAZ, while c-Myc (show MYC Antibodies) level is positively related to YWHAZ expression. These results suggested that c-Myc (show MYC Antibodies) dash, verticalmiR-451 dash, verticalYWHAZ/AKT (show AKT1 Antibodies) cascade might play a crucial role during leukemogenesis, and reintroduction of miR (show MLXIP Antibodies)-451 could be as a potential strategy for AML (show RUNX1 Antibodies) therapy.
The expression of zeta isoforms of 14-3-3 protein (show YWHAE Antibodies) was identified at substantial levels in the first instar larva, upregulated in the second instar larva, and the highest levels were maintained in the late stage of larva, the pupa, and the adult.
Caspase-2 (show CASP2 Antibodies) phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation.
identification of 14-3-3zeta as a novel phosphocofilin binding protein involved in the maintenance of the cellular phosphocofilin pool
DEX can increase IOP in mouse eyes and concurrently downregulate 14-3-3 zeta protein expression in mouse TM
These results demonstrate that miR (show MLXIP Antibodies)-146a enhances class switch and secretion of IgE in B cells by upregulating 14-3-3sigma expression, and suggest that miR (show MLXIP Antibodies)-146a may be a potential target for asthma therapy.
When taken together these findings demonstrate novel roles of 14-3-3zeta in the regulation of glucose homeostasis and suggest that modulating 14-3-3zeta levels in intestinal L cells may have beneficial metabolic effects through GLP-1 (show GCG Antibodies)-dependent mechanisms.
The data obtained from the 14-3-3epsilon/14-3-3zeta/Wnt1 (show WNT1 Antibodies)-Cre mice strongly indicate the importance of 14-3-3 (show YWHAQ Antibodies) proteins in the development of melanocyte lineages.
Results indicate that HuR (show ELAVL1 Antibodies) induces 14-3-3zeta translation via interaction with its 3' UTR (show UTS2R Antibodies) and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding.
PKCdelta (show PKCd Antibodies)-mediated phosphorylation of 14-3-3zeta contributes to the nuclear retention of FOXO1 (show FOXO1 Antibodies), even when FOXO1 (show FOXO1 Antibodies) is phosphorylated as under non-stress conditions
analysis of phosphorylation-dependent interactions of AQP2 (show AQP2 Antibodies) with 14-3-3theta; and -zeta
14-3-3zeta deficient mice in the BALB/c background display behavioral and anatomical defects associated with Schizophrenia-like disorder.
Ywhaz coordinates adipogenesis in visceral fat.
An essential role for 14-3-3 zeta in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1.
Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in YWHAZ.
Study suggests a novel mechanism of Tor regulation mediated by 14-3-3 interaction with Tctp (show TPT1 Antibodies) and Rheb (show RHEB Antibodies).
The Khc73 stalk/14-3-3/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
Hpo (show GFER Antibodies) signaling inhibited Yki (show YAP1 Antibodies) nuclear localization and activity by phosphorylating Yki (show YAP1 Antibodies) and both isoforms of 14-3-3, 14-3-3varepsilon and 14-3-3zeta, regulate Yki (show YAP1 Antibodies) activity through modulating its subcellular localization.
in vivo 14-3-3zeta monomer properties and functionality
monomeric D14-3-3zeta is capable of modulating dSlo channel activity in this regulatory complex.
These observations provide the first direct evidence that a 14-3-3 protein (show YWHAE Antibodies) functions as a stress-induced molecular chaperone (show HSP90AA1 Antibodies) that dissolves and renaturalizes thermal-aggregated proteins.
Results report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
, 14-3-3 protein zeta/delta
, 14-3-3 protein/cytosolic phospholipase A2
, 14-3-3 zeta
, phospholipase A2
, protein kinase C inhibitor protein 1
, protein kinase C inhibitor protein-1
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide
, 14-3-3 protein zeta
, tyrosine 3-monooxygenase protein zeta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide b
, factor activating exoenzyme S
, mitochondrial import stimulation factor S1 subunit
, 14-3-3 protein zeta a
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide a
, tyrosine 3/tryptophan 5-monooxygenase activation protein zeta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide
, D14 3 3 protein
, complementation group K
, leonardo 14-3-3
, tyrosine 3-monooxygenase
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide