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|Antigen||tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, zeta Polypeptide (YWHAZ) Antibodies|
|Conjugate||This YWHAZ antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-YWHAZ AntibodyTarget Details YWHAZ Application Details Handling References for anti-YWHAZ antibody (ABIN360667) Images
|Specificity||This antibody reacts to 14-3-3 protein zeta/delta.|
|Purification||Protein A column, followed by peptide affinity purification|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding T232 of human 14-3-3.|
Target Details YWHAZProduct Details anti-YWHAZ Antibody Application Details Handling References for anti-YWHAZ antibody (ABIN360667) Images back to top
|Alternative Name||14-3-3 Protein zeta/delta (YWHAZ Antibody Abstract)|
|Background||14-3-3 protein zeta/delta belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. This highly conserved protein family is found in both plants and mammals, and this protein is 99 % identical to the mouse, rat and sheep orthologs.Synonyms: KCIP-1, Protein kinase C inhibitor protein 1, YWHAZ|
|Gene ID||7534, 9606|
|Pathways||Apoptosis, Hormone Transport, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location|
Application DetailsProduct Details anti-YWHAZ Antibody Target Details YWHAZ Handling References for anti-YWHAZ antibody (ABIN360667) Images back to top
ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-YWHAZ Antibody Target Details YWHAZ Application Details References for anti-YWHAZ antibody (ABIN360667) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-YWHAZ antibody (ABIN360667)Product Details anti-YWHAZ Antibody Target Details YWHAZ Application Details Handling Images back to top
Li, Mofunanya, Harris, Takemaru: "Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity." in: The Journal of cell biology, Vol. 181, Issue 7, pp. 1141-54, 2008
Mateo, Llorca, Infante, Rodríguez-Rodríguez, Berciano, Combarros: "Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk." in: European journal of neurology : the official journal of the European Federation of Neurological Societies, Vol. 15, Issue 3, pp. 219-22, 2008
Li, Zhao, Du, Park, Sun, Bernal-Mizrachi, Aitken, Khuri, Fu: "Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 162-7, 2008
Powell, Rane, Joughin, Kalmukova, Hong, Tidor, Dean, Pierce, Klein, Yaffe, McLeish: "Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding." in: Molecular and cellular biology, Vol. 23, Issue 15, pp. 5376-87, 2003
ImagesProduct Details anti-YWHAZ Antibody Target Details YWHAZ Application Details Handling References for anti-YWHAZ antibody (ABIN360667) back to top