The ongoing SARS-CoV-2 pandemic has created urgent needs for intervention strategies to control the crisis. The spike (S) protein of the virus forms a trimer and catalyzes fusion between viral and target cell membranes - the first key step of viral infection.(1) The S protein is the most likely target of neutralizing antibodies as it is the main trans-membrane glycoprotein responsible for receptor-binding and virion entry.(2) S protein comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit).(3) The S1 subunit contains a receptor-binding domain (RBD) responsible for binding to the host cell receptor ACE2. NEW: Discover our selection of neutralizing antibodies!
Cai Y, Zhang J, Xiao T, Peng H, Sterling SM, Walsh RM, Rawson S, Rits-Volloch S, Chen B. Distinct conformational states of SARS-CoV-2 spike protein. bioRxiv [Preprint]. 2020 May 17:2020.05.16.099317. doi: 10.1101/2020.05.16.099317. PMID: 32511405; PMCID: PMC7263552.
Su QD, Yi Y, Zou YN, Jia ZY, Qiu F, Wang F, Yin WJ, Zhou WT, Zhang S, Yu PC, Bi SL, Shen LP, Wu GZ. The biological characteristics of SARS-CoV-2 spike protein Pro330-Leu650. Vaccine. 2020 Jul 6;38(32):5071-5075. doi: 10.1016/j.vaccine.2020.04.070. Epub 2020 Apr 30. PMID: 32513514; PMCID: PMC7190498.
Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell. 2020 Apr 16;181(2):281-292.e6. doi: 10.1016/j.cell.2020.02.058. Epub 2020 Mar 9. PMID: 32155444; PMCID: PMC7102599.