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the expression of three cytokines for the pathogenesis of osteoarthritis (OA). which include IL-1beta (show IL1B Proteins), MMP14 and GRP78 (show HSPA5 Proteins) was decreased by the various concentrations of icariin. These preliminary results imply that icariin might be an effective compound for the treatment of OA disease.
Overexpression of MMP-14 in familial amyloidotic polyneuropathy might be associated with the inflammatory process and can also contribute to further remodeling of the ECM (show MMRN1 Proteins).
MMP14 rs1042703 was associated with nominally shorter time to progression in malignant mesothelioma patients.
analysis of MT1-MMP structure and proteolytic activity
In squamous cell carcinoma of the cervix (SCCC), higher levels of MMP-14 expression were established in tumor cells, as evidenced by IHC (+3) and RT-PCR.Furin activity in the tumor was much higher than that in normal tissues. The expression of TIMP-2 (show TIMP2 Proteins) mRNA was sufficiently obvious in both the tumor and normal tissues to the bottom of the uterine cavity.
MMP-14 is regulated by a cascade of IL-6 (show IL6 Proteins) and p53 (show TP53 Proteins), demonstrating that the tumor microenvironment directly stimulates molecular changes in cancer cells to drive an invasive phenotype
cytomembrane MMP14 was induced by IL-6 (show IL6 Proteins) secreted from astrocytes, thereby enhancing the migration and invasion of glioma cells through activation of MMP2 (show MMP2 Proteins)
MMP-14 levels decrease in lungs from endotoxemic mice and serum from septic patients. * Mmp14 (-/-) mice show increased lung injury and mortality following endotoxemia. * Absence of Mmp14 decreases activated MMP-2 (show MMP2 Proteins) and increases S100A9 (show S100A9 Proteins) levels in lung tissue. * MMP-14 ameliorates inflammation by promoting S100A9 (show S100A9 Proteins) cleavage by activated MMP-2 (show MMP2 Proteins).
In turn, LIMK1 (show LIMK1 Proteins) and LIMK2 (show LIMK2 Proteins) are required for MT1-MMP-dependent matrix degradation and cell invasion in a three-dimensional type I collagen environment.
miR (show MLXIP Proteins)-337-3p directly binds to the MMP-14 promoter to repress MZF1 (show ZFP42 Proteins)-facilitatd MMP-14 expression, thus suppressing the progression of gastric cancer
MT1-MMP expressed by vascular smooth muscle cells plays a key role in limiting the progression of atherosclerosis in APOE (show APOE Proteins)-null mice by regulating proliferative responses and inhibiting the deterioration of VSMC function in atherogenic vascular walls.
Study documents that MT1-MMP is widely expressed in the tooth and surrounding connective tissues during development and postnatal growth. Consistent with this expression, loss of MT1-MMP in mice impairs tooth root formation and eruption in association with multiple defects in dentoalveolar tissues.
Authors demonstrate that CAIX (show CA9 Proteins) associates with MMP14 through potential phosphorylation residues within its intracellular domain, and that CAIX (show CA9 Proteins) enhances MMP14-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 catalytic activity.
High mmp14 expression is associated with Lung Metastasis of Breast Cancer.
Although neither proteinase is required for branching morphogenesis, transcriptome profiling reveals a key role for MMP14 and MMP15 (show MMP15 Proteins) in regulating mammary gland adipocyte differentiation. Whereas MMP14 promotes the generation of white fat depots crucial for energy storage, MMP15 (show MMP15 Proteins) differentially controls the formation of thermogenic brown fat.
The authors identified the membrane-tethered matrix metalloprotease (show ADAMTS7 Proteins) MT1-MMP as a prominent host-extracellular matrix-remodeling collagenase in influenza infection.
MMP-14 expression in fibroblasts plays a crucial role in collagen remodeling in adult skin and largely contributes to dermal homeostasis underlying its pathogenic role in fibrotic skin disease in a mouse model
MT1-MMP directly cleaves LYVE-1 (show LYVE1 Proteins) on lymphatic endothelial cells to inhibit LYVE-1 (show LYVE1 Proteins)-mediated lymphangiogenic responses and restrains the production of VEGF-C (show VEGFC Proteins).
results suggest that ET-1 (show EDN1 Proteins)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (show NOX1 Proteins)-PKCalpha (show PKCa Proteins)-p(38)MAPK (show MAPK1 Proteins) and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 (show TIMP2 Proteins) expression in the cells
Data indicate the involvement of PKC-alpha (show PKCa Proteins) in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Proteins) expression by NF-kappaB (show NFKB1 Proteins)-MT1-MMP-dependent and -independent pathway.
Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2 (show MMP2 Proteins); MMP-14) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.
MMP-14, MMP-2 (show MMP2 Proteins) and TIMP-2 (show TIMP2 Proteins) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
Results describe distinct changes in expression of MMP2 (show MMP2 Proteins), MMP14, and the metallopeptidase (show ECEL1 Proteins) inhibitor TIMP2 (show TIMP2 Proteins) between different phases of the estrous cycle indicating an endocrine regulation.
EMMPRIN from the luminal epithelium may regulate the expression of stromal MMP-2 (show MMP2 Proteins) and MMP-14 suggesting a role in adhesion and fusion of embryo to luminal epithelium.
MT1-MMP seems to act by inducing tissue remodeling in cartilage
sphingosine 1-phosphate is the predominant serum factor essential for MT1-MMP-dependent migration and morphogenic differentiation of vascular endothelial cells
MT1-MMP plays a crucial role in RAGE (show AGER Proteins)-activated NADPH oxidase (show NOX1 Proteins)-dependent signaling pathways.
MMP-1 (show MMP1 Proteins) was involved in osteoarthritis development in rabbit ACLT model and the amount of its expression was related with the degree of cartilage degradation.
Modulation of MT1-MMP activity and microRNA-133a exportation into the myocardial interstitium occurred in the setting of acute myocardial ischemia-reperfusion.
A heterogeneous response in MT1-MMP activity likely contributes to regional dysfunction with ischemia-reperfusion. Subsequent I/R activates a proteolytic cascade within the MI region, contributing to continued adverse remodeling.
PI3K-dependent regulation of MT1-MMP protein synthesis and subsequent activation of latent MMP-2 (show MMP2 Proteins) as critical events in neointimal hyperplasia after vascular injury.
Induction of endogenous MMP-14 gene and coexpression of SAF-1 (show MAZ Proteins) & MMP-14 in the macrophages present in the atherosclerotic plaque implicate SAF-1 (show MAZ Proteins) as a key regulator of MMP-14 gene induction in macrophage cells.
In an isolated left ventricular myocyte ischemia/reperfusion model, hypoxia induced a >70% increase in MT1-MMP abundance in myocytes. Confocal microscopy revealed MT1-MMP internalization during this time & reemergence to the membrane with reperfusion.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily\; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
matric metalloproteinase 14
, matrix metalloproteinase-14
, membrane type 1 metalloprotease
, membrane-type-1 matrix metalloproteinase
, MT-MMP 1
, Membrane type 1-MMP
, matrix metalloproteinase 14 (membrane-inserted)
, membrane-type matrix metalloproteinase 1
, type 1 matrix metalloprotease 14
, matrix metalloproteinase 14 membrane-inserted
, matrix metalloproteinase 14, membrane-inserted
, membrane type 1-matrix metalloproteinase
, matrix metalloproteinase 14 preproprotein
, matrix metallopeptidase 1 (interstitial collagenase)
, matrix metalloproteinase 14
, membrane type 1 metalloproteinase
, membrane-type 1 matrix metalloproteinase
, membrane type-1 metalloproteinase