Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Human Polyclonal PTGS2 Primary Antibody for IHC (fro), IHC (p) - ABIN3044296
Guo, Li, Wu, Gong, Lu, Shi: Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2010
Show all 15 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for IHC, IHC (p) - ABIN152112
Chu, Yeh, Lin, Jung, Ma, Wang, Wu, Shiu, Chen: Deletion of the FHL2 gene attenuating neovascularization after corneal injury. in Investigative ophthalmology & visual science 2008
Show all 14 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for IHC (p), WB - ABIN3044295
Liu, Yan, Li, Yin, Sun, Kou, Ye, Ferns, Liu, Liu: Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/?-catenin signaling pathway. in Journal of ovarian research 2014
Show all 14 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for IF (p), IHC (p) - ABIN672471
Gao, Wen, Yang, Lu, Tong, Huang, Liu, Tang: Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. in PLoS ONE 2013
Show all 10 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for ELISA, WB - ABIN257712
George, Morrow, Xu, Yi, Holmes, Wu, Li, Protter, Oz, Wang: Prolonged effects of B-type natriuretic peptide infusion on cardiac remodeling after sustained myocardial injury. in American journal of physiology. Heart and circulatory physiology 2009
Show all 4 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for IHC (p), WB - ABIN965923
Salmenkivi, Haglund, Ristimäki, Arola, Heikkilä: Increased expression of cyclooxygenase-2 in malignant pheochromocytomas. in The Journal of clinical endocrinology and metabolism 2001
Show all 4 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for IHC (p), IHC - ABIN257983
Tong, Tai: Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells. in Biochemical and biophysical research communications 2000
Show all 2 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for IF (p), IHC (p) - ABIN2173482
Niu, Wang, Li, Mu, Li, Yao, Zhang: Protective effects of Isofraxidin against lipopolysaccharide-induced acute lung injury in mice. in International immunopharmacology 2015
Show all 2 Pubmed References
Human Polyclonal PTGS2 Primary Antibody for IHC, IHC (p) - ABIN4300170
Nuñez, Bravo, Cruzat, Montecino, De Ferrari: Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells. in PLoS ONE 2011
Show all 2 Pubmed References
Chicken Polyclonal PTGS2 Primary Antibody for IHC, ELISA - ABIN1582099
Hsieh, Yang, Yang, Chou: Dry needling at myofascial trigger spots of rabbit skeletal muscles modulates the biochemicals associated with pain, inflammation, and hypoxia. in Evidence-based complementary and alternative medicine : eCAM 2013
Show all 2 Pubmed References
Results suggest that a significant correlation exists in Japan between the COX-2 (show COX2 Antibodies) 1195 G-carrier genotype and intestinal metaplasia in histological and endoscopic findings based on Kyoto classification in H. pylori-infected gastric mucosa.
activated Ras, protumorigenic COX-2 (show COX2 Antibodies) and Notch1 (show NOTCH1 Antibodies) have roles in in papillary mucinous neoplasm onset
TGF-beta1 (show TGFB1 Antibodies) increased the COX-2 (show COX2 Antibodies) and PGE2 level of cultured pulp cells. The effect of TGF-beta1 (show TGFB1 Antibodies) on COX-2 (show COX2 Antibodies) protein expression was associated with ALK5 (show TGFBR1 Antibodies)/Smad2 (show SMAD2 Antibodies)/3 and MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) pathways.
Culinary herbs and spices prevent the growth of HCA-7 colorectal adenocarcinoma cancer cells and inhibit their COX-2 (show COX2 Antibodies) expression.
medical use of COX (show COX8A Antibodies) inhibitors in glioblastoma treatment has been limited due to their well-documented vascular toxicity and inconsistent outcomes from recent human studies. Prostaglandin E2 (PGE2) has emerged as a principal mediator for COX-2 (show COX2 Antibodies) cascade-driven gliomagenesis
COX2 (show COX2 Antibodies) inversely regulated Notch1 (show NOTCH1 Antibodies) in gastric cancer and partially depended on the Notch1 (show NOTCH1 Antibodies) signalling pathway in altering the expression of Snail (show SNAI1 Antibodies).
Based on the contribution maps from the three techniques, it can be concluded that both the benzenesulfonyl group and the central five-membered ring - having a high-electronegativity functional group or atom or having a substituent hydrogen bonding acceptor - contribute positively to the selective inhibition of COX-2 (show COX2 Antibodies)
Findings demonstrate that COX-2 (show COX2 Antibodies) and p-Akt1 (show AKT1 Antibodies) play an important combined role during melanoma progression and are associated with highly metastatic tumors and survival rates in patients with MM.
Results suggest that higher COX-2 (show COX2 Antibodies) expression may be a negative prognostic factor in conjunctival melanoma. Further studies can address the potential use of anti-COX-2 (show COX2 Antibodies) drugs as adjuvant therapy of this disease.
activation of ERK1/2 signaling was required for hCG-induced up-regulation of SPRY2 expression. Further, SPRY2 knockdown attenuated the AREG-induced COX-2 expression and PGE2 production by inhibiting AREG-activated ERK1/2 signaling.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta (show IL1B Antibodies),COX-2 (show COX2 Antibodies), and TGFbeta1 (show TGFB1 Antibodies)
The result demonstrate that mechanical stress on synovial cells induces gene expressions of COX-2 (show COX2 Antibodies).
Diabetes enhances the vasodilator response of the rabbit carotid artery to testosterone by a mechanism that includes an increased modulatory activity of the endothelial nitric oxide and an augmented release of COX-2 (show COX2 Antibodies) vasodilator, prostacyclin.
Local induction of COX-2 (show COX2 Antibodies) during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 (show COX2 Antibodies) inhibitors may increase vascular reactivity at sites of atherosclerotic lesions.
These findings suggest that nuclear factor kappa B(NF-kappaB (show NFKB1 Antibodies)) and cyclooxygenase-2 play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.
COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.
These results suggest that COX-2 plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.
Brain death increases the expression of COX-1 (show COX1 Antibodies) and COX-2 mRNA in the renal medulla
COX-2 is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.
In porcine vas (show AVP Antibodies) deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 at the mRNA and protein levels.
expression appears to be positively and negatively regulated by p38 MAPK (show MAPK14 Antibodies) and JNK (show MAPK8 Antibodies) pathways; alternatively, ERK1/2 appear to be involved in COX-2-independent reparative events that remain to be defined
Neutrophils augment recovery of transepithelial electrical resistance in ischemia-injured ileal mucosa via IL-1beta (show IL1B Antibodies)-dependent upregulation of COX-2. (Cyclooxygenase 2)
Administration of estrogen early in pregnancy alters endometrial prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA and protein expression, which may disrupt pregnancy causing total embryonic loss during implantation in the pig.
The effect of EGF (show EGF Antibodies) on pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha (show TNF Antibodies)) and cyclooxygenase-2 (COX-2), levels during wound healing in swine is reported.
Mitochondrial catalase (show CAT Antibodies) induces neoplastic cell transformation through nucleolin (show NCL Antibodies)-dependent Cox-2 (show COX2 Antibodies) mRNA stabilization.
The COX2 (show COX2 Antibodies)-dependent lipid inflammatory pathway is responsible for lethality in F. novicida infection due to overproduction of proinflammatory effectors including prostaglandin E2.
These data indicate the functional role of the MIF (show MIF Antibodies)-COX (show CPOX Antibodies)-p53 (show TP53 Antibodies) axis in inflammation and cancer at the genomic and proteomic levels in COX-2 (show COX2 Antibodies)-ablated cells.
PTGS2 deletion changes the natural distribution of ANXA2 (show ANXA2 Antibodies) in monocytes/macrophages, increasing TF expression and activity predisposing to venous thrombosis.
Study suggest that amyloid beta-protein increase the expression of TRPC6 (show TRPC6 Antibodies) via NF-kappaB (show NFKB1 Antibodies) in BV-2 microglia and promotes the production of COX-2 (show COX2 Antibodies), which induces hippocampus neuron damage.
Data show that patients with high cyclooxygenase-2 (COX2) gene expression who received celecoxib had a significantly higherpathological complete response (pCR) rate compared with patients with low COX2 (show COX2 Antibodies) gene expression.
Topical application of glycolic acid suppresses the UVB induced IL-6 (show IL6 Antibodies), IL-8 (show IL8 Antibodies), MCP-1 (show CPT1B Antibodies) and COX-2 (show COX2 Antibodies) inflammation by modulating NF-kappaB (show NFKB1 Antibodies) signaling pathway in mouse skin.
COX-2 (show COX2 Antibodies)/mPGES-1 (show PTGES Antibodies)/PGE2 cascade activation mediates uric acid-induced glomerular mesangial cell proliferation.
Cobalt protoporphyrin induces COX-2 (show COX2 Antibodies) expression through activating P2X7 (show P2RX7 Antibodies) receptors and ASK1 (show MAP3K5 Antibodies)/MAP kinases as well as PIAS1 (show PIAS1 Antibodies) degradation signaling pathways.
sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 (show JUN Antibodies) which, in turn, induces COX-2 (show COX2 Antibodies) expression.
Data suggested that PTGS-2 gene expression was induced by PTGER2 (show PTGER2 Antibodies) activation through the PKA and ERK (show MAPK1 Antibodies) pathways.
The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.
results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha (show NR1D1 Antibodies)) plays an inhibitory role in the expression of prostaglandin-endoperoxide synthase 2(PTGS2) in both bovine USCs and UECs treated with ovarian steroids
This study showed that neutrophils from periparturient heifers show impairment of COX-2 mRNA expression and lactoferrin (show LTF Antibodies), suggesting that these mechanisms may contribute to immunosuppression in cows around calving.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2, and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1 (show NR3C1 Antibodies). TNF (show TNF Antibodies) and IL6 (show IL6 Antibodies) levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
Purinergic P2Y1 receptor (show P2RY1 Antibodies) signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts
Data suggest that Escherichia coli infections (here, administration of LPS (show IRF6 Antibodies)) provokes luteolysis in diestrus, non-lactating cows but no change in expression of PTGS2 in corpus luteum and has no effect on luteinization in the following cycle.
This study is the first to report the involvement of PGE2 in oocyte MAPK (show MAPK1 Antibodies) activation during the maturation process.
Inhibitors of c-Src (show SRC Antibodies) (PP2, 10 microm) and PI3K (LY294002, 25 microm) produced a significant decrease in oxytocin-induced PGF (show PGF Antibodies)(2 alpha) production and reduced COX2 expression by endometrial epithelial cells.
COX-2 pathway is responsible for the endometrial production of PGE (show LIPF Antibodies)(2) in the bovine endometrium during the estrous cycle
This study showed that COX-1 (show PTGS1 Antibodies) and COX-2 in genital carcinomas in the horse is poor; microsomal PGES (show PTGES Antibodies)-1 is more prominently expressed.
Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor (show OXTR Antibodies), and cyclooxygenase 2 in fetal membranes and endometrium.
COX-1 (show PTGS1 Antibodies) and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.
The role for p38 (show MAPK14 Antibodies) mitogen-activated kinase (MAPK (show MAPK1 Antibodies)) in the signaling mechanism regulating pro-inflammatory cyclooxygenase (COX (show CPOX Antibodies)) gene expression in lipopolysaccharide (LPS (show IRF6 Antibodies))-activated equine leukocytes in horses is reported.
In this study, both COX-1 (show PTGS1 Antibodies) and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.
Immunoreactivity for COX-1 (show PTGS1 Antibodies) and COX-2 is high in equine corneal SCC (show CYP11A1 Antibodies), possibly indicating that COX (show CPOX Antibodies) plays a role in oncogenesis or progression of this tumor type at this site.
It was found that most equine squamous-cell carcinomas and many melanomas appear to express COX-2 and thus could respond to COX-2 inhibitor therapy.
data support the hypothesis that prostaglandin G/H synthase 2(PGHS2)is a target for the antiluteolytic signal produced by equine conceptuses during early pregnancy
The vesicular gland of castrated goats showed significantly lower AR and COX-2 (show COX2 Antibodies) immuno-expression than intact goats indicating that both AR and COX-2 (show COX2 Antibodies) are androgen dependent.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
PGH synthase 2
, PHS II
, cyclooxygenase 2b
, prostaglandin G/H synthase 2
, prostaglandin H2 synthase 2
, cyclooxygenase 2
, glucocorticoid-regulated inflammatory cyclooxygenase
, macrophage activation-associated marker protein P71/73
, prostaglandin G/H synthase and cyclooxygenase
, mitogen-inducible PGHS
, cyclooxygenase type 2
, prostaglandin G/H synthase-2
, cyclooxygenase, prostaglandin endoperoxide H synthase-2
, prostaglandin H synthase-2
, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
, prostaglandin G/H synthase 2-like