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anti-Human CACNA1H Antibodies:
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Human Monoclonal CACNA1H Primary Antibody for ISt, IHC - ABIN1304584
Martinello, Huang, Lujan, Tran, Watanabe, Cooper, Brown, Shah: Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells. in Neuron 2015
Show all 8 Pubmed References
Human Monoclonal CACNA1H Primary Antibody for ICC, IHC (fro) - ABIN447362
García-Caballero, Gadotti, Stemkowski, Weiss, Souza, Hodgkinson, Bladen, Chen, Hamid, Pizzoccaro, Deage, François, Bourinet, Zamponi: The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity. in Neuron 2014
Show all 2 Pubmed References
In colonic biopsies, the Cav3.2 mRNA level was significantly higher in the irritable bowel syndrome group compared to controls.
human Cav3.1, Cav3.2, and Cav3.3 T-type channels specifically associate with CaM at helix 2 of the gating brake in the I-II linker of the channels.
Here we show that T-type channels Cav3.1 (show CACNA1G Antibodies) and Cav3.2 are present in the lung and PASMCs from iPAH patients and control subjects. The blockade of T-type channels by the specific blocker, TTA-A2, prevents cell cycle progression and PASMCs growth
Our data establish Stac1 (show STAC Antibodies) as an important modulator of T-type channel expression and provide new insights into the molecular mechanisms underlying the trafficking of T-type channels to the plasma membrane.
CACNA1H variant is associated with differential antiepileptic drug response in childhood absence epilepsy.
There is a direct link between CACNA1H(M1549V) mutation and an increased aldosterone production. This suggests that calcium channel blockers may be beneficial in the treatment of a subset of patients with primary aldosteronism.
CACNA1H might be a susceptibility gene predisposing to PA with different phenotypic presentations, opening new perspectives for genetic diagnosis and management of patients with PA.
heterozygous mutations identified in a pediatric patient with chronic pain and absence seizures result in loss of channel function, with significantly smaller current densities across a wide range of voltages when co-expressed in tsA (show PRDX2 Antibodies)-201 cells.
CaV3.1 (show CACNA1G Antibodies), CaV3.2 and CaV3.3 (show CACNA1I Antibodies) channels, are best recognized for their negative voltage of activation and inactivation thresholds that allow them to operate near the resting membrane potential of neurons.
Study revealed no association between the 15 tagSNPs of CACNA1A (show CACNA1A Antibodies), 1C, and 1H and antiepileptic drug efficacy in the Chinese Han epileptic population; the TAGAA haplotype of CACNA1A (show CACNA1A Antibodies) may be a risk factor for drug resistance
Findings provided morphological evidence that T-type Cav3.2 channel, at least partially, mediates the pain facilitation of insulin-like growth factor-1/insulin-like growth factor-1 (show IGF1 Antibodies) receptor (show IGF1R Antibodies) signaling in chronic inflammatory pain condition.
This study found that expressions of Cav3.2 and IGF-1R (show IGF1R Antibodies), and their colocalization were not increased in DRGs of mice following axotomy. In addition, Cav3.2 or IGF-1R (show IGF1R Antibodies) subpopulation neurons did not acquire significant switch in expression phenotype after sciatic nerve axotomy.
Sensitization was relieved by pharmacological block of TRPV1 (show TRPV1 Antibodies) afferents, but not of myelinated neurons. In spinal cord slice recordings, we could optogenetically trigger an activity-dependent potentiation of presynaptic neurotransmission in the spinal dorsal horn that relied on Cav3.2 channel activity. This neuronal-activity-induced USP5 (show USP5 Antibodies) upregulation may underlie a protective, transient sensitization of the pain pathway.
The important roles of the CaV (show CA5A Antibodies) 3.2 T-type calcium channels in myogenic tone.
findings show that 2 Amyotrophic lateral sclerosis (ALS)-associated missense mutations produce alterations on the channel activity, consistent with a loss of channel function; findings implicate CACNA1H as a susceptibility gene in one form of ALS
findings suggest that chronic intermittent hypoxia leads to an augmented calcium influx via reactive oxygen species -dependent facilitation of CaV3.2 protein trafficking to the plasma membrane.
these data show that CaV3.2 T-type channels have prev8iously unrecognized roles in supporting the meiotic-maturation-associated increase in ER Ca(2 (show CA2 Antibodies)+) stores and mediating Ca(2 (show CA2 Antibodies)+) influx required for the activation of development.
MTF1 (show MTF1 Antibodies) mediates the increase of CaV3.2 mRNA and a rise in intracellular Zn(2+) which is associated with status epilepticus.
both suramin and gossypetin produced dose-dependent and long-lasting mechanical anti-hyperalgesia that was abolished or greatly attenuated in Cav3.2 null mice
Data show increased expression of T-type Ca(2 (show CA2 Antibodies)+) current and association of protein kinase C alpha (PKCalpha (show PKCa Antibodies)) with caveolin-3 (Cav-3 (show CAV3 Antibodies))was disrupted in the hypertrophic ventricular myocyte.
This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE).
calcium channel, voltage-dependent, T type, alpha 1Hb subunit
, low-voltage-activated calcium channel alpha1 3.2 subunit
, low-voltage-activated calcium channel alpha13.2 subunit
, voltage dependent t-type calcium channel alpha-1H subunit
, voltage-dependent T-type calcium channel subunit alpha-1H
, voltage-gated calcium channel alpha subunit Cav3.2
, voltage-gated calcium channel alpha subunit CavT.2
, voltage-gated calcium channel subunit alpha Cav3.2
, T-type Cav3.2
, calcium channel alpha13.2 subunit