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We determined a crystal structure of CaM bound to a peptide encompassing its binding site in AKAP79. CaM adopts a highly compact conformation in which its open Ca(2 (show CA2 Proteins)+)-activated C-lobe and closed N-lobe (show LTF Proteins) cooperate to recognize a mixed alpha/310 helix in AKAP79.
A short-linear interaction motif between residues 337-343 of AKAP79 is the sole PP2B-anchoring determinant sustaining these diverse topologies.
Studies indicate the importance of the AKAP79/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 (show CA1 Proteins) region of the hippocampus.
Cigarette smoke-induced changes in AKAP5 and AKAP12 in patients with COPD (show ARCN1 Proteins) may affect efficacy of pharmacotherapy.
human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330
GPR30 interacted with membrane-associated guanylate kinases and protein kinase A-anchoring protein (AKAP) 5 in the plasma membrane in a PDZ-dependent manner.
a significant role for the AKAP5 scaffold in signaling and trafficking of the beta1-AR in cardiac myocytes and mammalian cells.
Patients with bipolar disorder have higher density of AKAP5-expressing neurons in the anterior cingulate cortex compared with controls.
AKAP79, PKC (show PRRT2 Proteins), PKA and PDE4 (show PDE4A Proteins) participate in a Gq-linked muscarinic receptor (show CHRM5 Proteins) and adenylate cyclase 2 (show ADCY2 Proteins) cAMP signalling complex.
The results of this study suggested that antagonizing the TRPV1 (show TRPV1 Proteins)-AKAP79 interaction will be a useful strategy for inhibiting inflammatory hyperalgesia.
the C-helix of protein kinase A inhibitory regulatory subunit is identified as a highly dynamic switch which relays cyclic AMP (show TMPRSS5 Proteins) binding to the helical catalytic-subunit binding regions
AKAP150 regulates Ca(2 (show CA2 Proteins)+ )cycling and myocardial ionotropy following pathological stress, promoting pathological remodelling and heart failure propensity.
AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction.
This study demonstrated that the AKAP150 oordinates metabotropic glutamate (show GRIN1 Proteins) receptor sensitization of peripheral sensory neurons.
Thus, our present study revealed that AKAP5 plays a significant role in the regulation of sympathetic nerve activities.
Identify a novel cardioprotective role for AKAP5 that is mediated by regulating the activities of cardiac CaN and CaMKII (show CAMK2G Proteins) and highlight a significant role for cardiac beta-ARs (show SLURP1 Proteins) in this phenomenon.
endothelial-dependent dilation of resistance arteries is enabled by MEP (show CTSL1 Proteins)-localized AKAP150, which ensures the proximity of PKC to TRPV4 (show TRPV4 Proteins) channels and the coupled channel gating necessary for efficient communication from endothelial to smooth muscle cells
Our results support a model whereby subcellular anchoring of CaN by AKAP150 is a key molecular determinant of vascular BKCa (show KCNMA1 Proteins) channel remodeling, which contributes to vasoconstriction during diabetes mellitus.
Anchoring of protein kinase A and adenylyl cyclase by AKAP5 is important for regulation of postsynaptic functions and specifically AMPA (show GRIA3 Proteins) receptor activity.
the direct anchoring of both PKA and AC to TRPV1 (show TRPV1 Proteins) by AKAP79/150 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia.
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
A kinase (PRKA) anchor protein 5
, A-kinase anchor protein 5
, A-kinase anchor protein 5-like
, a-kinase anchor protein 5-like
, A-kinase anchor protein 79 kDa
, A-kinase anchor protein, 79kDa
, A-kinase anchoring protein 75/79
, AKAP 79
, cAMP-dependent protein kinase regulatory subunit II high affinity binding protein
, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
, A-kinase anchor protein 75 kDa
, AKAP 75
, anchor protein regulatory subunit (AKAP75)
, A-kinase anchor protein 150 kDa
, AKAP 150
, RII-B-binding protein