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Human PDE4A Protein expressed in HEK-293 Cells - ABIN2728507
Taniguchi, Iizumi, Watanabe, Masuda, Morita, Aono, Toriyama, Oishi, Goi, Sakai: Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer. in Cell death & disease 2016
In conclusion, our data demonstrated that UFM24 inhibits oxidative burst in human neutrophils through inhibition of PDE4 activity. UFM24 also exhibited significant protection against endotoxin-induced acute lung injury (ALI)in mice. UFM24 has potential as an anti-inflammatory agent for treating neutrophilic lung damage.
PDE4 inhibition reduces neointima formation and inhibits VCAM-1 (show VCAM1 Proteins) expression and histone methylation in an Epac (show RAPGEF3 Proteins)-dependent manner.
results suggest that PDE4A may be important in the regulation of emotional memory and anxiety-like behavior, but not emesis
This study showed that long PDE4 isoforms provide a novel node for cross-talk between the cAMP and p38 MAPK (show MAPK14 Proteins) signalling systems at the level of MK2 (show KCNA2 Proteins).
Increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for PDE4A10 in cardiac myocytes.
a new mechanism in which phosphodiesterase PDE4A4/5 interacts with p75(NTR (show NGFR Proteins)) to enhance cAMP degradation
Repurposing the PDE4 inhibitor roflumilast for treatment of B-cell malignancies is safe, suppresses the oncogenic PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) kinases, and may be clinically active
The expression of PDE4A4 and PDE4A8 in normal pituitary, their increased expression in adenomatous pituitary cells where AIP (show AIP Proteins) is meant to participate, and the disruption of the PDE4A4-AIP (show AIP Proteins) interaction by AIP (show AIP Proteins) mutants may play a role in pituitary tumorigenesis.
the well-known interaction between AIP (show AIP Proteins) and 2 different isoforms of phosphodiesterases (PDEs), PDE2A3 and PDE4A5, is of particular interest. While the interaction with over-expressed AIP (show AIP Proteins) does not seem to affect PDE2A3 function, the reported effect on PDE4A5 is, in contrast, reduced enzymatic activity.
Low PDE4A expression is associated with sepsis.
Findings demonstrate loss of PDE4 expression in the striato-thalamo-cortical circuit, which is associated with deficits of spatial working memory in patients with Parkinson disease.
A multifunctional docking site on the catalytic unit of PDE4 that is utilized by multiple interaction partners has been identified.
curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 (show PDE2A Proteins) and PDE4 inhibition
After 48 h yessotoxin treatment PDE4A-dependent autophagy, as non-apoptotic programmed cell death, is activated.
AKAP 149 (show AKAP1 Proteins)-PKA-PDE4A complex localization is related with YTX effect in K-562 cell line
Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM (show BCAM Proteins)) through phosphodiesterase 4A activation.
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
phosphodiesterase 4A, cAMP-specific
, phosphodiesterase 4A-like
, phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
, cyclic AMP-specific phosphodiesterase FCPDE4A1A
, cyclic AMP-specific phosphodiesterase OCPDE4A1A
, phosphodiesterase 4A, cAMP specific
, cyclic AMP-specific phosphodiesterase CPPDE4A1A
, cAMP-specific 3',5'-cyclic phosphodiesterase 4A
, cAMP-specific phosphodiesterase PDE4A
, cyclic AMP specific phosphodiesterase PDE4A5A
, phosphodiesterase 4A, cAMP-specific (dunce
, phosphodiesterase E2 dunce homolog, Drosophila
, phosphodiesterase isozyme 4
, cyclic AMP-specific phosphodiesterase SSPDE4A1A