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anti-Human FOXA3 Antibodies:
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Cow (Bovine) Polyclonal FOXA3 Primary Antibody for IHC, WB - ABIN2777513
Kaestner: The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism. in Trends in endocrinology and metabolism: TEM 2001
Show all 2 Pubmed References
in FoxA2-FoxA3 double morphants, precursors of axial tissues are correctly induced at early gastrula stage, but their dorsal midline identity is not maintained during development
FoxA3 and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a.
Our study identified novel FOXA3 variants and mutations, assessed the adipogenic capacity of two novel missense alterations in vitro and demonstrated for the first time the associations between FOXA3 SNP rs28666870 with metabolic phenotypes in humans.
Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity in asthma and chronic obstructive pulmonary disease.
In obese subjects, FOXA3 is differentially expressed in visceral and subcutaneous adipose depots.
low caloric intake decreases the production of intracellular reactive oxygen species and suppresses endothelial cells senescence through promoting HNF3gamma binging to NOX4 promoter region and inhibiting NOX4 gene expression induced by up-regulated HNF3gamma
analysis of the binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells
the HNF-3 site in the fibrinogen beta promoter is important for IL6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism
FOXA3 is a marker of the Sertoli cell lineage and of the adult Leydig cell population, and is a regulator of Pdgfra transcription in Leydig cells.
These findings reveal an obligatory coregulatory role of Foxa3 in the regulation of ER-alpha expression and of the Foxa3/ER-alpha cascade, at least in part, in the pathogenesis of androgen deficiency caused by type 2 diabetes mellitus.
These results demonstrated the crucial role of Hnf1b and Foxa3 in hepatogenesis in vitro and provided a valuable tool for the efficient differentiation of HLCs from ES cells.
studies provide the first demonstration, to our knowledge, that Foxa3 is a direct target of GC action in adipose tissues and point to a role of Foxa3 as a mediator of the side effects induced in fat tissues by chronic treatment with synthetic steroids
transcription factor Foxa3 was a strong promoter of liver regeneration.
during aging, Foxa3 is up-regulated in brown and inguinal white fat depots, and midage Foxa3-null mice have increased white fat browning and thermogenic capacity, decreased adipose tissue expansion, improved insulin sensitivity, and increased longevity
Foxa3 promotes adipocyte differentiation by cooperating with C/EBP beta and - delta to transcriptionally induce PPAR gamma expression.
these results suggested that oxidative stress inhibited Akt signaling and facilitated the FOXO-3a/FBXO-dependent BK-beta(1) degradation in diabetic vessels.
FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program
Intraovarian excess androgen in polycystic ovary syndrome may result in excess follicles by inducind Foxo 3a translocation.
binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression.
Foxa3 is a transcriptional regulator with a dominant phenotype in germ cell maintenance
the results document that the hepatic FOXA family of genes are differentially regulated by amino acid availability
Unlike FOXA2, FOXA3 did not regulate mucous metaplasia in allergic airway disease and asthma.
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved.
forkhead box A3
, fork head domain protein 2
, hepatocyte nuclear factor 3-gamma
, fork head-related protein FKH H3
, forkhead box protein A3
, hepatocyte nuclear factor 3, gamma
, transcription factor 3G
, foxhead box A3
, hepatocyte nuclear factor 3 gamma
, hepatocyte nuclear factor 3 gamma (winged helix transcription factor)