FOXA3 antibody (C-Term)

Catalog No. ABIN2779850

This Rabbit Polyclonal antibody specifically detects FOXA3 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse and Pig.

Quick Overview for FOXA3 antibody (C-Term) (ABIN2779850)

Target: FOXA3 (Forkhead Box A3 (FOXA3))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXA3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FOXA3 Antibody

Binding Specificity: C-Term

Purpose: Foxa3 Antibody - C-terminal region

Sequence: YNFNHPFSIN NLMSEQTSTP SKLDVGFGGY GAESGEPGVY YQSLYSRSLL

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 79%, Horse: 86%, Human: 86%, Mouse: 100%, Pig: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Foxa3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the c terminal region of mouse Foxa3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36881-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for FOXA3

Target: FOXA3 (Forkhead Box A3 (FOXA3))

Alternative Name: Foxa3

Background:

Background Information: Foxa3 is a transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Foxa3 is originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Foxa3 interacts with the cis-acting regulatory regions of these genes.Foxa3 is involved in glucose homeostasis, activates GLUT2 transcription and regulation of neuronal-specific transcription. Foxa3 is also involved in regulation of spermatogenesis, required for the maintenance of the testicular germ cell population and male fertility.

Gene Name: Forkhead box A3

Alternative Symbols: Hnf3, Hnf-3, Hnf3g, Tcf3g, Hnf-3g, Tcf-3g

Protein Name: Hepatocyte nuclear factor 3-gamma

Molecular Weight: 37kDa

Gene ID: 15377

NCBI Accession: NP_032286

UniProt: P35584

Pathways: Carbohydrate Homeostasis