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anti-Human Hexokinase 1 Antibodies:
anti-Mouse (Murine) Hexokinase 1 Antibodies:
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Human Monoclonal Hexokinase 1 Primary Antibody for ICC, IHC - ABIN969194
Tsai: Function of interdomain alpha-helix in human brain hexokinase: covalent linkage and catalytic regulation between N- and C-terminal halves. in Journal of biomedical science 2007
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Human Polyclonal Hexokinase 1 Primary Antibody for IHC (p), ELISA - ABIN544935
Murakami, Kanno, Miwa, Piomelli: Human HKR isozyme: organization of the hexokinase I gene, the erythroid-specific promoter, and transcription initiation site. in Molecular genetics and metabolism 1999
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Human Polyclonal Hexokinase 1 Primary Antibody for IHC (p), ELISA - ABIN544934
van Wijk, Rijksen, Huizinga, Nieuwenhuis, van Solinge: HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia. in Blood 2002
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Human Monoclonal Hexokinase 1 Primary Antibody for ICC, FACS - ABIN969195
Grupe, Li, Rowland, Nowotny, Hinrichs, Smemo, Kauwe, Maxwell, Cherny, Doil, Tacey, van Luchene, Myers, Wavrant-De Vrièze, Kaleem, Hollingworth, Jehu, Foy, Archer, Hamilton, Holmans, Morris, Catanese et al.: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ... in American journal of human genetics 2005
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Human Polyclonal Hexokinase 1 Primary Antibody for IHC (p), WB - ABIN392759
Lynn, Wang, Markesbery, Lovell: Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease. in Journal of Alzheimer's disease : JAD 2010
Human Monoclonal Hexokinase 1 Primary Antibody for ELISA, WB - ABIN532961
Ellison, Lueck, Fromm: Studies on the mechanism of orthophosphate regulation of bovine brain hexokinase. in The Journal of biological chemistry 1975
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Cow (Bovine) Polyclonal Hexokinase 1 Primary Antibody for WB - ABIN6746932
Fallon, Moreau, Croft, Labib, Gu, Fon: Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. in The Journal of biological chemistry 2002
Human Polyclonal Hexokinase 1 Primary Antibody for ICC, IF - ABIN4317157
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Human Monoclonal Hexokinase 1 Primary Antibody for ELISA, WB - ABIN2473989
Wilson: Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. in The Journal of experimental biology 2003
The results distinguished two ovarian cancer phenotypes, one with elevated HK activity and low G6Pase activity, and another with the opposite characteristics.
Our replicated associations with HK1 and IL18R1 suggest that variants in inflammatory pathways, such as the biologically-plausible NLRP3 inflammasome, may contribute to nocturnal hypoxemia.
The authors found that in addition to retinitis pigmentosa, HK1 E851K missense mutation can also cause dominant macular dystrophy and cone-rod dystrophy, which primarily affect cone photoreceptors instead of rods.
Mutation in c-Src phosphorylation site of either HK1 or HK2 remarkably abrogates the stimulating effects of c-Src on glycolysis, cell proliferation, migration, invasion, tumorigenesis and metastasis
HK1 competes with SOD1 G93A mutant from familial amyotrophic lateral sclerosis cases for binding VDAC1.
HK1 protein levels was decreased after luteolin treatment and partly restored when co-treated with luteolin and miR-34a inhibitor.
The pathogenic nature of the identified missense mutations was confirmed by biochemical and 3-dimensional structural analysis. The effects of the novel splice site mutation c.873-2A>G were studied at the level of pre-mRNA processing, and confirmed at the protein level. Four of the 6 mutations studied were new.
STAT3 expression is upregulated in both HBV- and HCV-related hepatocellular carcinoma (HCC), while hexokinase II (HK-II) is predominantly upregulated and correlated to STAT3 in HBV-related HCC
Russe type hereditary motor and sensory neuropathy belongs to the most frequent types of hereditary neuropathy in the Czech Republic, which affects Roma and is caused by a HK1 mutation.
Data suggest that overexpression of hexokinase 1 (HK1) may act as a significant biomarker of poor prognosis for patients with colorectal cancer (CRC).
4-hydroxytamoxifen resistance in breast cancer cells is suppressed by curcumin, which targets the SLUG/Hexokinase 2 pathway
Our results suggest that overexpression of PKM2 and HK1, especially the latter, significantly associates with lymphatic metastasis, advanced clinical staging and unfavorable prognosis in gastric cancer.
The transport of glucose across the cell membrane by glucose transporters (GLUTs) and intracellular phosphorylation by hexokinases (HKs) are the initial steps of the glycolytic pathway.
HK1 and HK2 expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 expression level was significantly increased in 60% of samples.
Data indicate a missense mutation in hexokinase 1 (HK1) c.2539G > A, p.Glu847Lys, tracking with disease in all affected family members.
HK1 expression is highly enriched in neurons compared to astrocytes in the cerebral cortex.
HK-1 plays a non-metabolic role in HIV-1 infected macrophages by binding to mitochondria thereby maintaining mitochondrial integrity.
The present study was designed to evaluate the involvement of hexokinase and CPT-1 in the cell growth and proliferation of human prostate cancer cell lines, PC3, and LNCaP-FGC-10.
HK1 is expressed in retina, with two abundant isoforms expressed at similar levels. The Glu847Lys mutation is located at a highly conserved position in the protein, outside the catalytic domains.
Here, we identified HK1 as a novel causative gene for adRP. This is the first report that associates the glucose metabolic pathway with human retinal degenerative disease, suggesting a potential new disease mechanism.
HXK1 regulates cell proliferation and expansion early during leaf development, and that HXK1 is involved in sucrose-induced leaf growth stimulation independent of GPT2.
HXK1 affects the expression of PIPaquaporins genes and reduce leaf water conductance, to coordinate sugar levels with the loss of water through transpiration.
role in cell death mediated by myo-inositol accumulation
The structure of HXK1 was determined both in its inactive unliganded form and in its active glucose-bound form at resolutions of 1.8 and 2.0 A, respectively.
The CO2 metabolism of the gin2-1 mutation in A. thaliana is reported.
HXK1 mediated stimulation of NRT2.1 expression.
Data suggest that regulation of NIA1 and NIA2 nitrate reductases (NR) activity by sugars does not involve HXK1 as a glucose sensor.
Increased expression of HXK in guard cells accelerates stomatal closure.
Overexpression of AtHXK1 inhibits growth and accelerates leaf senescence under normal growth conditions.
HKL1 and HXK1 can interact, these two proteins likely form a critical node in Glc signaling that mediates overlapping, but also distinct, cellular responses to Glc and ethylene treatments.
HXK1-dependent glucose signaling uncoupled from other plant stress and defense hormone signaling has a central regulatory role in early seedling establishment.
Hexokinase expression is highly enriched in neurons compared to astrocytes.
The interaction of DREAM with hexokinase I may be important in the regulation of neuronal apoptosis.
Standard chow affects body weight, heart weight and HK activity and HKI expression in the heart, without altering HKII expression.
HK1S is tethered in the principal piece region by PFKMS, which in turn is bound tightly to GSTM5 in the fibrous sheath of sperm.
HK-1 alone was sufficient to induce the activation of MAPKs and the expression of Blimp-1 and Xbp-1 in B cells.
The comprehensive sequencing analysis and fine mapping approximately 26 kb of fully characterised sequence spanning the upstream exons of Hexokinase 1 (HK1), is reported.
A new spontaneous mutation in the A/J inbred mouse strain, downeast anemia (dea), causes severe hemolytic anemia with extensive tissue iron deposition and marked reticulocytosis
Expression in embryonic heart is increased by exposure to tolbutamide, but this is acute and not sustained.
the Hexokinase-mitochondria interaction mediated by Akt has a role in inhibiting apoptosis but does not require Bax and Bak
RanBP2 associates in vitro and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11, and the pacemaker of glycolysis, hexokinase type I (HKI) via its leucine-rich domain.
Between these two strategies to activate glycogen deposition in the absence of GK, embryonic livers choose to express massive levels of HKI and HKII.
First demonstration of a cytotoxic mechanism based on direct interaction between an anticancer agent and hexokinase.
Cleavage of disulfide bonds in HK1S dimers contributes to the increases in HK activity and motility that occur when mouse sperm become activated.
results point to HK-I and HK-II as promoting tumor cell survival through binding to VDAC1, thereby inhibiting cytochrome c release and apoptotic cell death.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus\; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.
, brain form hexokinase
, glycolytic enzyme
, hexokinase type I
, hexokinase 1
, hexokinase I
, downeast anemia
, hexokinase, tumor isozyme
, chloroplast outer envelope hexokinase 1
, hexokinase 1 L homeolog