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anti-Human Hexokinase 1 Antibodies:
anti-Mouse (Murine) Hexokinase 1 Antibodies:
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Human Monoclonal Hexokinase 1 Primary Antibody for ICC, IHC - ABIN969194
Tsai: Function of interdomain alpha-helix in human brain hexokinase: covalent linkage and catalytic regulation between N- and C-terminal halves. in Journal of biomedical science 2007
Show all 3 Pubmed References
Human Monoclonal Hexokinase 1 Primary Antibody for ICC, FACS - ABIN969195
Grupe, Li, Rowland, Nowotny, Hinrichs, Smemo, Kauwe, Maxwell, Cherny, Doil, Tacey, van Luchene, Myers, Wavrant-De Vrièze, Kaleem, Hollingworth, Jehu, Foy, Archer, Hamilton, Holmans, Morris, Catanese et al.: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ... in American journal of human genetics 2005
Show all 2 Pubmed References
Cow (Bovine) Polyclonal Hexokinase 1 Primary Antibody for WB - ABIN611559
Fallon, Moreau, Croft, Labib, Gu, Fon: Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. in The Journal of biological chemistry 2002
Human Monoclonal Hexokinase 1 Primary Antibody for ELISA, WB - ABIN2473989
Wilson: Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. in The Journal of experimental biology 2003
Human Polyclonal Hexokinase 1 Primary Antibody for ICC, IF - ABIN4317157
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Human Polyclonal Hexokinase 1 Primary Antibody for IHC (p), WB - ABIN392759
Lynn, Wang, Markesbery, Lovell: Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease. in Journal of Alzheimer's disease : JAD 2010
HK1 (show KCNA4 Antibodies) competes with SOD1 (show SOD1 Antibodies) G93A mutant from familial amyotrophic lateral sclerosis cases for binding VDAC1 (show VDAC1 Antibodies).
HK1 (show KCNA4 Antibodies) protein levels was decreased after luteolin treatment and partly restored when co-treated with luteolin and miR (show MLXIP Antibodies)-34a inhibitor.
The pathogenic nature of the identified missense mutations was confirmed by biochemical and 3-dimensional structural analysis. The effects of the novel splice site mutation c.873-2A>G were studied at the level of pre-mRNA processing (show PRPF39 Antibodies), and confirmed at the protein level. Four of the 6 mutations studied were new.
STAT3 (show STAT3 Antibodies) expression is upregulated in both HBV- and HCV-related hepatocellular carcinoma (HCC (show FAM126A Antibodies)), while hexokinase II (HK-II (show HK2 Antibodies)) is predominantly upregulated and correlated to STAT3 (show STAT3 Antibodies) in HBV-related HCC (show FAM126A Antibodies)
Russe type hereditary motor and sensory neuropathy belongs to the most frequent types of hereditary neuropathy in the Czech Republic, which affects Roma and is caused by a HK1 (show KCNA4 Antibodies) mutation.
Data suggest that overexpression of hexokinase 1 (HK1) may act as a significant biomarker of poor prognosis for patients with colorectal cancer (CRC (show CALR Antibodies)).
4-hydroxytamoxifen resistance in breast cancer cells is suppressed by curcumin, which targets the SLUG/Hexokinase 2 (show HK2 Antibodies) pathway
Our results suggest that overexpression of PKM2 (show PKM2 Antibodies) and HK1 (show KCNA4 Antibodies), especially the latter, significantly associates with lymphatic metastasis, advanced clinical staging and unfavorable prognosis in gastric cancer.
HK1 (show KCNA4 Antibodies) and HK2 (show HK2 Antibodies) expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 (show HK3 Antibodies) expression level was significantly increased in 60% of samples.
Data indicate a missense mutation in hexokinase 1 (HK1) c.2539G > A, p.Glu847Lys, tracking with disease in all affected family members.
HXK1 affects the expression of PIPaquaporins genes and reduce leaf water conductance, to coordinate sugar levels with the loss of water through transpiration.
role in cell death mediated by myo (show SYNPO2 Antibodies)-inositol accumulation
The structure of HXK1 was determined both in its inactive unliganded form and in its active glucose-bound form at resolutions of 1.8 and 2.0 A, respectively.
The CO2 metabolism of the gin2-1 mutation in A. thaliana is reported.
HXK1 mediated stimulation of NRT2.1 expression.
Data suggest that regulation of NIA1 and NIA2 nitrate reductases (NR) activity by sugars does not involve HXK1 as a glucose sensor.
Overexpression of AtHXK1 inhibits growth and accelerates leaf senescence under normal growth conditions.
HKL1 (show ZNF354A Antibodies) and HXK1 can interact, these two proteins likely form a critical node in Glc signaling that mediates overlapping, but also distinct, cellular responses to Glc and ethylene treatments.
HXK1-dependent glucose signaling uncoupled from other plant stress and defense hormone signaling has a central regulatory role in early seedling establishment.
Hexokinase expression is highly enriched in neurons compared to astrocytes.
The interaction of DREAM with hexokinase I may be important in the regulation of neuronal apoptosis.
Standard chow affects body weight, heart weight and HK activity and HKI (show TAC4 Antibodies) expression in the heart, without altering HKII (show HK2 Antibodies) expression.
HK1S is tethered in the principal piece region by PFKMS, which in turn is bound tightly to GSTM5 (show GSTM5 Antibodies) in the fibrous sheath of sperm.
HK-1 alone was sufficient to induce the activation of MAPKs and the expression of Blimp-1 (show PRDM1 Antibodies) and Xbp-1 (show XBP1 Antibodies) in B cells.
The comprehensive sequencing analysis and fine mapping approximately 26 kb of fully characterised sequence spanning the upstream exons of Hexokinase 1 (HK1), is reported.
A new spontaneous mutation in the A/J inbred mouse strain, downeast anemia (dea), causes severe hemolytic anemia with extensive tissue iron deposition and marked reticulocytosis
the Hexokinase-mitochondria interaction mediated by Akt (show AKT1 Antibodies) has a role in inhibiting apoptosis but does not require Bax (show BAX Antibodies) and Bak (show BAK1 Antibodies)
RanBP2 (show RANBP2 Antibodies) associates in vitro and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11 (show COX11 Antibodies), and the pacemaker of glycolysis, hexokinase type I (HKI) via its leucine-rich domain.
Between these two strategies to activate glycogen (show GYS1 Antibodies) deposition in the absence of GK, embryonic livers choose to express massive levels of HKI (show TAC4 Antibodies) and HKII (show HK2 Antibodies).
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus\; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.
, brain form hexokinase
, glycolytic enzyme
, hexokinase type I
, hexokinase 1
, hexokinase I
, downeast anemia
, hexokinase, tumor isozyme
, chloroplast outer envelope hexokinase 1
, hexokinase 1 L homeolog