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anti-Human MLXIPL Antibodies:
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Human Polyclonal MLXIPL Primary Antibody for ChIP, ICC - ABIN152902
Wang, Botolin, Xu, Christian, Mitchell, Jayaprakasam, Nair, Nair, Peters, Peters, Busik, Busik, Olson, Jump: Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. in Journal of lipid research 2006
Show all 95 Pubmed References
Human Polyclonal MLXIPL Primary Antibody for ICC, IF - ABIN152903
Proszkowiec-Weglarz, Humphrey, Richards: Molecular cloning and expression of chicken carbohydrate response element binding protein and Max-like protein X gene homologues. in Molecular and cellular biochemistry 2008
Show all 6 Pubmed References
Polyclonal MLXIPL Primary Antibody for IF, WB - ABIN540822
Letexier, Pinteur, Large, Fréring, Beylot: Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue. in Journal of lipid research 2003
Show all 3 Pubmed References
Human Monoclonal MLXIPL Primary Antibody for ICC, ELISA - ABIN1724913
Hurtado del Pozo, Vesperinas-García, Rubio, Corripio-Sánchez, Torres-García, Obregon, Calvo: ChREBP expression in the liver, adipose tissue and differentiated preadipocytes in human obesity. in Biochimica et biophysica acta 2011
Show all 2 Pubmed References
Human Polyclonal MLXIPL Primary Antibody for IHC, IHC (p) - ABIN446286
Butcher, Torrecilla, Young, Kong, Mistry, Bottrill, Tobin: N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons. in The Journal of biological chemistry 2009
Show all 2 Pubmed References
Human Polyclonal MLXIPL Primary Antibody for ICC, IF - ABIN4298323
Kaushik, Shojaie, Panzitt, Sonavane, Venghatakrishnan, Manikkam, Zaslavsky, Putluri, Vasu, Zhang, Khan, Lloyd, Szafran, Dasgupta, Bader, Stossi, Li, Samanta, Cao, Tsouko, Huang, Frigo, Chan, Edwards et al.: Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. ... in Nature communications 2016
ChREBP and FGF21 constitute a signaling (show FGF21 Antibodies) axis likely conserved in humans that mediates an essential adaptive response to fructose ingestion that may participate in the pathogenesis of NAFLD and liver fibrosis.
The results of this population-based study provide evidence for a relationship between lipid regulatory gene polymorphisms including GCKR (show GCKR Antibodies) (rs780094), GCKR (show GCKR Antibodies) (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) with dyslipidemia in an Iranian population.
Data (including data from studies using tissues/cells from transgenic mice) suggest that ChREBPalpha up-regulates expression and activity of NRF2 (show GABPA Antibodies), initiating mitochondrial biogenesis in beta-cells; induction of NRF2 (show GABPA Antibodies) is required for ChREBPalpha-mediated effects and for glucose-stimulated beta-cell proliferation. [NRF2 (show GABPA Antibodies) = nuclear factor (erythroid-derived 2)-like 2 (show NFE2L2 Antibodies) protein]
ChREBP was initially studied as a master regulator of lipogenesis in liver and fat tissue, it is now clear that ChREBP functions as a central metabolic coordinator in a variety of cell types in response to environmental and hormonal signals, with wide implications in health and disease.
A nutrient-sensitive mTOR (show FRAP1 Antibodies)/ChREBP regulated transcriptional network could be a novel target to improve beta cell survival and glucose homeostasis in diabetes.
these findings support a carbohydrate-mediated, ChREBP-driven mechanism that contributes to hepatic insulin (show INS Antibodies) resistance.
results indicated that the age and total cholesterol concentrations were independent influential factors of ChREBP methylation and DNMT1 (show DNMT1 Antibodies) variants could probably influence LDL-C to further modify ChREBP DNA methylation (show HELLS Antibodies)
p = 6.69 x 10(-9) ] on chr7 at the carbohydrate-responsive element-binding protein-encoding (MLXIPL) gene locus displayed significant protective characteristics, while another variant rs6982502 [0.76 (0.68-0.84); p = 5.31 x 10(-7) ] on chr8 showed similar but weaker properties.
ChREBP role in non-alcoholic fatty liver disease.The involvement of ChREBP in FASN (show FASN Antibodies) promoter histone modification.
This cross-sectional study suggests that MLXIPL rs3812316 genotypes may be associated with Triglyceride levels. there were significantly different genotype distributions in two TG categories: (1) subjects with normal TG values had a significantly higher G allele frequency than those with elevated TG levels
ChREBP and SHP (show LAMC1 Antibodies) control the regulation of hepatic microsomal triglyceride transfer protein (show MTTP Antibodies) expression and VLDL Secretion. Adenoviral Overexpression of ChREBP and SHP (show LAMC1 Antibodies) Respectively Increased and Decreased Mttp (show MTTP Antibodies) Expression.
The acute increase in circulating FGF21 (show FGF21 Antibodies) following fructose gavage was absent in ChREBP knockout mice. Induction of ChREBP-beta and its glycolytic, fructolytic, and lipogenic gene targets were attenuated in FGF21 (show FGF21 Antibodies) knockout mice fed high-fructose diets.
Data, including data from studies in knockout mice, suggest that ChREBP is involved in coordinate regulation of sucrose and fructose absorption/metabolism by modulating gene expression in intestinal mucosa and liver.
Authors have identified a previously unappreciated negative feedback loop by which glucose-induced ChREBP-beta downregulates ChREBP-alpha-signaling providing new insight into the physiological role of islet ChREBP-beta and into the regulation of glucose-induced gene expression.
loss of adipose-ChREBP is sufficient to cause insulin (show INS Antibodies) resistance potentially by regulating AT glucose transport.
Glucose-challenged Chrebp-/- mice exhibit a marked reduction in FGF21 (show FGF21 Antibodies) production.
Study identify O-GlcNAcylation on Ser514 in the C-terminus of ChREBP and validate two important sites, Thr517 and Ser839 for O-GlcNAcylation and their function. Ser514 phosphorylation enhances ChREBP O-GlcNAcylation, maintaining the transcriptional activity of ChREBP; Ser839 O-GlcNAcylation is essential for its heterodimerization, DNA-binding activity, and nuclear export.
Data suggest that triiodothyronine and high glucose signal coordinately to up-regulate ChREBP, Ucp1 (show UCP1 Antibodies), Glut4 (show SLC2A4 Antibodies), and Fasn (show FASN Antibodies) in brown adipocytes; ChREBP plays role as a central regulator of brown adipocyte activity/energy metabolism. (ChREBP = carbohydrate-responsive element-binding protein; Ucp1 (show UCP1 Antibodies) = uncoupling protein-1 (show UCP1 Antibodies); Glut4 (show SLC2A4 Antibodies) = facilitated glucose transporter (show SLC2A12 Antibodies)-4; Fasn (show FASN Antibodies) = fatty acid synthase (show FASN Antibodies), type-I)
findings suggest that a previously unknown link exists between ChREBP and the regulation of cholesterol synthesis that affects liver injury.
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.
MLX interacting protein-like
, carbohydrate response element binding protein variant 1
, carbohydrate response element binding protein variant 2
, Williams-Beuren syndrome chromosomal region 14 protein homolog
, carbohydrate responsive element binding protein
, williams-Beuren syndrome chromosomal region 14 protein homolog
, MLX-interacting protein-like
, Mlx interactor
, WS basic-helix-loop-helix leucine zipper protein
, Williams Beuren syndrome chromosome region 14
, Williams-Beuren syndrome chromosome region 14 protein 1
, Williams-Beuren syndrome chromosome region 14 protein 2
, carbohydrate response element binding protein
, carbohydrate-responsive element-binding protein
, class D basic helix-loop-helix protein 14
, williams-Beuren syndrome chromosomal region 14 protein
, MLX interacting protein-like beta
, MLX interactor
, Williams-Beuren syndrome chromosome region 14 homolog
, putative hepatic transcription factor
, WBSCR14 protein-like
, Williams-Beuren syndrome chromosomal region 14 protein