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Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment, one is via PCK1, and a second via PPDK.
Malate metabolism is important during dark-induced stomatal closure and that phosphoenolpyruvate carboxykinase (PEPCK) is involved in this process.
Study investigated the molecular basis of such effects focusing on a commonly studied polymorphism in pig Pgc1alpha, which changes a cysteine at position 430 (WT) of the protein to a serine (C430S); found that differential O-GlcNAcylation of Pgc1alpha regulates PCK1 activity and this molecular mechanism could explain at least in part the epistatic interaction between both genes.
Study identified a novel homozygous PCK1 missense mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia.
HBXIP (show HBXIP Proteins) is able to depress the gluconeogenesis in hepatoma cells by suppressing PCK1 to promote hepatocarcinogenesis, involving miR (show MLXIP Proteins)-135a/FOXO1 (show FOXO1 Proteins) axis and PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/p-FOXO1 (show FOXO1 Proteins) pathway.
A mutation of PCK1 associated with Smith-Magenis Syndrome, cytosolic PEPCK (show PEPCK Proteins) deficiency and NMDA receptor glutamate (show GRIN1 Proteins) insensitivity.
Insulin (show INS Proteins)-dependent translocation of FOXO1 (show FOXO1 Proteins) regulated transcriptional repression of PCK1 concomitant with the formation of the FOXO1 (show FOXO1 Proteins)-euchromatic histone-lysine N-methyltransferase2 (show DNMT1 Proteins) (EHMT2 (show EHMT2 Proteins)) complex and histone modifications of the PCK1 promoter region
Lipopolysaccharide and monophosphoryl lipid A also up-regulated G6PC (show G6PC Proteins) and PCK1 transcript abundance in a TLR4 (show TLR4 Proteins)-dependent manner.
The PCK1 tag-single nucleotide polymorphisms influenced insulin (show INS Proteins) resistance by interacting with plasma n-3 polyunsaturated fatty acids levels in metabolic syndrome patients.
HCV core protein expression-mediated FOXO1 (show FOXO1 Proteins) activation and the increased PGC-1alpha leaded to the elevation of PCK1 at the mRNA level
Acetylation regulates the stability of the gluconeogenic rate-limiting enzyme PEPCK1.
Data show PEPCK-C and CPT-1 (show CPT1A Proteins) mRNAs are more abundant in non-tumoral tissues than in the tumoral counterpart, whereas the opposite occurred for the FAS (show FAS Proteins) gene.
the renal proximal tubule, may require the remodeling of AUF1 (show HNRNPD Proteins) binding to the elements that mediate the rapid turnover of PEPCK (show PEPCK Proteins) mRNA
Collectively, the identified 3'-untranslated-region SNP variant highlights the importance of PCK1 in the fecundity of Holstein bulls, and implicates a role for bta-miR (show MYLIP Proteins)-26a in regulating PCK1 abundance.
Expression of cytosolic PEPCK (show PEPCK Proteins) mRNA is transiently increased during early lactation, indicating that enhanced hepatic gluconeogenesis during lactation may be tied to enhanced capacity for cytosolic formation of phosphoenolpyruvate.
Data (including data from studies in knockout mice) suggest that Pck1 in liver plays role in glucose homeostasis; here, Pck1 deficiency (in knockout mice) can be successfully treated by re-expression of Pck1 in liver, thus partially rescuing pups from fatal neonatal hypoglycemia. Pck1 appears to play roles in metabolism in lung and skeletal muscle.
Silencing PCK1 or inhibiting its enzymatic activity slows the growth of tumor-repopulating cells in vitro and impedes tumorigenesis in vivo.
PEPCK-M expression partially rescued defects in lipid metabolism, gluconeogenesis and TCA cycle function impaired by PEPCK-C deletion, while approximately 10% re-expression of PEPCK-C normalized most parameters.
FAT/CD36 (show CD36 Proteins) regulates PEPCK (show PEPCK Proteins) in adipose tissue and that this could be secondary to reductions in lipolysis.
PCB (show PC Proteins) 126 blunted the forskolin-stimulated increase in phosphoenolpyruvate carboxykinase (PEPCK (show PEPCK Proteins)) mRNA levels.
the role of IL-6 (show IL6 Proteins) signalling in adipose tissue during exercise
there are multiple cytokine pathways by which inflammation inhibits PEPCK (show PEPCK Proteins) expression in adipose tissue which could contribute to the increased mobilization of fatty acids during inflammation
Glucagon (show GCG Proteins) can also regulate Pck1 in the intestine, but not in the kidneys.
Pck1 plays an important role in both the mammary gland adipocytes and epithelial cells during lactation
Results suggest that HDAC3 (show HDAC3 Proteins) mediates NF-kappaB (show NFKB1 Proteins) activity to repress Pepck (show PEPCK Proteins) transcription.
The regulatory properties of maize phosphoenolpyruvate carboxylase were significantly altered by site-directed mutagenesis of residues 226 through 232.
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.
, phosphoenol pyruvate carboxykinase
, phosphoenolpyruvate carboxy kinase
, phosphoenolpyruvate carboxykinase
, phosphoenolpyruvate carboxykinase, cytosolic
, phosphoenolpyruvate carboxykinase 1 (soluble)
, Phosphoenolpyruvate carboxykinase, cytosolic
, Phosphoenolpyruvate carboxykinase 1 (soluble)-like
, cytosolic phosphoenolpyruvate carboxykinase
, phosphoenolpyruvate carboxykinase, cytosolic [GTP]
, phosphoenolpyruvate carboxylase
, PEP carboxykinase
, phosphopyruvate carboxylase
, phosphoenolpyruvate carboxykinase 1 variant 1
, phosphoenolpyruvate carboxykinase 1 variant 2
, phosphoenolpyruvate carboxykinase 1 variant 3
, phosphoenolpyruvate carboxykinase 1 variant 4
, phosphoenolpyruvate carboxykinase 1 variant 5
, phosphoenolpyruvate carboxykinase (GTP)
, phosphoenolpyruvate carboxykinase 1, cytosolic
, phosphoenolpyruvate carboxykinase, cytosolic (GTP)
, gluconeogenic enzyme
, synonymous gene name: Pep2 in maize linkage map