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Studies indicate Special AT-rich Sequence Binding Protein 1 (SATB1) to affect proliferation, cell cycle, apoptosis, cell morphology / cell polarity, EMT (show ITK Proteins) and multidrug-resistance as well as tumor formation, growth, invasion and metastasis [Review].
Study results in bladder cancer are consistent with the conflicting data reported in other cancers, and that SATB1 might have different roles in cancer dependent on genetic background and stage of the cancer. The role of SATB1 is dependent on multiple factors, its use as a biomarker limited and as a therapeutic target likely highly variable among patients.
The aim of this study was to investigate the expression of p16 and SATB1 proteins in regard to expression of the Ki-67 (show MKI67 Proteins) antigen and available clinicopathological data (i.a. receptor status, staging and grading
HBx upregulated hepatic SATB1.
Invasion and metastasis of GIN in Chinese patients correlates with SATB1 overexpression in tumor tissues, most profoundly in gastric cancer.
High SATB1 expression is associated with Immunosuppressive Function of Regulatory T Cells in Chronic Hepatitis B.
SATB2 (show SATB2 Proteins) can induce dedifferentiation by inducing stemness and may have a role in pancreatic carcinogenesis
High SATB1 expression was associated with a better overall survival of patients with non-small cell lung carcinoma.ATB1 level correlates with Ki-67 (show MKI67 Proteins) expression in non-small cell lung carcinoma.
These data implied that SATB1 might regulate gene expression through its different oligomerization state.
High SATB1 expression is associated with glioblastoma.
SATB1 is essential for maintaining TCR responsiveness during the induction and effector phases and may provide a novel therapeutic target for T cell-mediated autoimmune diseases.
Satb1 promotes osteoclastogenesis by recruiting CREB-binding protein (show CREBBP Proteins) to upregulate miR (show MLXIP Proteins)-223 expression in chronic kidney disease-mineral and bone disorder
SATB1 shapes the primary T cell pool by directing lineage-specific transcriptional programs in the thymus.
SATB1cKO mice, in which the SATB1 gene is specifically deleted from hematopoietic cells, develop Sjogren syndrome by 4 wk of age, soon after weaning.
RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3 (show GATA3 Proteins), SATB1, and IRF4 (show IRF4 Proteins).
these results identify a role for Satb1 in the lineage choice between pluripotency and differentiation and further our understanding of early embryonic lineage segregation.
This study demonstrating that Satb1-dependent Cntn5 (show CNTN5 Proteins) expression in ON-OFF direction-selective ganglion cells leads to branch-specific homophilic interactions with interneurons.
we show that special AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development
this study shows that Satb1-dependent Treg cell-specific super-enhancers activation is crucial for Treg cell lineage specification in the thymus
Tumor-driven, unremitting expression of Satb1 in activated Zbtb46 (show ZNF340 Proteins)+ inflammatory DCs that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by increased secretion of tumor-promoting Galectin-1 (show LGALS1 Proteins) and IL-6 (show IL6 Proteins).
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.
DNA-binding protein SATB1
, special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)
, special AT-rich sequence-binding protein 1
, special AT-rich sequence binding protein 1
, SATB homeobox 1
, AT-rich binding protein-1
, DNA-binding protein SATB1-like
, SATB homeobox 1a