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SATB1 may reprogram energy metabolism in ovarian cancer by regulating lactate dehydrogenase and MCT1 levels to promote metastasis.
Studies indicate Special AT-rich Sequence Binding Protein 1 (SATB1) to affect proliferation, cell cycle, apoptosis, cell morphology / cell polarity, EMT and multidrug-resistance as well as tumor formation, growth, invasion and metastasis [Review].
Study results in bladder cancer are consistent with the conflicting data reported in other cancers, and that SATB1 might have different roles in cancer dependent on genetic background and stage of the cancer. The role of SATB1 is dependent on multiple factors, its use as a biomarker limited and as a therapeutic target likely highly variable among patients.
The aim of this study was to investigate the expression of p16 and SATB1 proteins in regard to expression of the Ki-67 antigen and available clinicopathological data (i.a. receptor status, staging and grading
HBx upregulated hepatic SATB1.
Invasion and metastasis of GIN in Chinese patients correlates with SATB1 overexpression in tumor tissues, most profoundly in gastric cancer.
High SATB1 expression is associated with Immunosuppressive Function of Regulatory T Cells in Chronic Hepatitis B.
SATB2 can induce dedifferentiation by inducing stemness and may have a role in pancreatic carcinogenesis
High SATB1 expression was associated with a better overall survival of patients with non-small cell lung carcinoma.ATB1 level correlates with Ki-67 expression in non-small cell lung carcinoma.
These data implied that SATB1 might regulate gene expression through its different oligomerization state.
High SATB1 expression is associated with glioblastoma.
These findings suggest SATB1 may play an important role in OSCC invasiveness and metastasis.
This paper provides evidence that SATB1 plays an oncogenic role in esophageal cancer by up-regulation of FN1 and PDGFRB.
combination of the sequence-specific and nonspecific DNA-binding modes of SATB1 should be advantageous in a search for target loci during transcriptional regulation
revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 in T cells, such as Raptor, CHEK1, CREB1, RUNX1, SATB1, Ikaros, and Helios.
SATB1 interacts directly with OGG1, increases its binding to 8-oxoG-containing DNA, promotes Schiff base formation, and stimulates its glycosylase and apyrimidinic/apurinic lyase enzymatic activities.
High SATB1 expression in was detected in 48.3% of esophageal squamous cell carcinoma and 7.8% of normal esophagus tissues.
Silencing of special AT-rich sequence binding protein 1 inhibited the proliferation of KYSE450 and EC9706 cells which have a relatively high level of special AT-rich sequence binding protein 1, and the ability of migration and invasion of KYSE450 and EC9706 cells was distinctly suppressed.
Results suggest that SATB1 is activated to bind to chromatin at S/MARs after exposure to Abeta 1-42, resulting in alternative utilization and movement of 82-kDa ChAT to these regions demonstrating that both proteins play critical roles in the response of neural cells to acute Abeta-exposure.
Our results highlight the significance of SATB1 in intrahepatic cholangiocarcinoma
Study using a mouse model with reduced IL-2 signaling revealed that IL-2, possibly through the positioning of the genome organizer SATB1, modulates thymic-derived Treg cell epigenetic identity prior to Foxp3 expression.
SATB1 is essential for maintaining TCR responsiveness during the induction and effector phases and may provide a novel therapeutic target for T cell-mediated autoimmune diseases.
Satb1 promotes osteoclastogenesis by recruiting CREB-binding protein to upregulate miR-223 expression in chronic kidney disease-mineral and bone disorder
SATB1 shapes the primary T cell pool by directing lineage-specific transcriptional programs in the thymus.
SATB1cKO mice, in which the SATB1 gene is specifically deleted from hematopoietic cells, develop Sjogren syndrome by 4 wk of age, soon after weaning.
RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4.
these results identify a role for Satb1 in the lineage choice between pluripotency and differentiation and further our understanding of early embryonic lineage segregation.
This study demonstrating that Satb1-dependent Cntn5 expression in ON-OFF direction-selective ganglion cells leads to branch-specific homophilic interactions with interneurons.
we show that special AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development
this study shows that Satb1-dependent Treg cell-specific super-enhancers activation is crucial for Treg cell lineage specification in the thymus
Tumor-driven, unremitting expression of Satb1 in activated Zbtb46+ inflammatory DCs that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by increased secretion of tumor-promoting Galectin-1 and IL-6.
These results suggest that SATB1 plays an essential role in establishment of immune tolerance.
Data show that RNA binding protein HuD and special adenine-thymine (AT)-rich DNA-binding protein 1 (SATB1) form a positive regulatory loop that enhances NeuroD1 protein transcription and subsequent neuronal differentiation.
Fluorosed mouse ameloblasts have increased SATB1 retention and Galphaq activity.
The results indicated that the expression of SATB1 in both mRNA and protein levels was significantly decreased after cells transferred with siRNA sequence for 48 h, the proliferation of MF9 cells was significantly inhibited.
SATB1 binds to the ASE and Rag promoters, facilitating inclusion of Rag2 in the chromatin hub and the loading of RNA polymerase II to both the Rag1 and Rag2 promoters.
SATB1 is indispensable for lymphocyte differentiation and stem cell development. (Review)
The ubiquitin-like domain-CUT repeat-like tandem of SATB1 are required for DNA binding.
governs lymphoid lineage specification
Satb1 is a regulator that promotes hematopoietic stem cells quiescence and represses lineage commitment.
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.
DNA-binding protein SATB1
, special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)
, special AT-rich sequence-binding protein 1
, special AT-rich sequence binding protein 1
, SATB homeobox 1
, AT-rich binding protein-1
, DNA-binding protein SATB1-like
, SATB homeobox 1a