Browse our anti-Agouti Signaling Protein (ASIP) Antibodies

Human Agouti Signaling Protein (ASIP) interaction partners

1. ASIP expression is significantly downregulated in human masticatory mucosa during wound healing

2. Polymorphisms of ASIP were found to be associated with skin, hair, and eye color in a phenotypically diverse Brazilian population. More research is needed to determine its usefulness in forensic science.

3. ASIP gene mutation is involved in the development of facial pigmented lesions.

4. Data show that ASIP TG/TG diplotype, which is known to be associated with melanoma risk, was linked to a 5-fold increase in hazard of death from melanoma.

5. An increased risk of melanoma (odds ratio [OR] 1.27, 95% confidence interval [95% CI] 1.03-1.57) in carriers of the rs4911414 variant, located 120 kb upstream of ASIP.

6. By using a population-based material of high-risk melanoma cases, we demonstrate a significant effect of both MC1R red hair color (RHC) variants and an ASIP haplotype, but could not replicate an association with postulated risk SNPs of TYR and TYRP1.

7. Findings suggest that ASIP locus is associated with a number of non-melanoma skin cancers.

8. Further analysis of binding and functional data suggests that the ASIP C-terminal loop (a six-amino-acid segment closed by the final disulfide bond) is essential for high-affinity MC1R binding and inverse agonism.

9. polymorphism in the agouti signaling protein gene is associated with human pigmentation

10. results show that men and women of similar age and BMI present similar agouti signal protein mRNA levels in omental and subcutaneous abdominal adipocytes but a sexual dimorphism exists in the relationship between its expression and BMI

11. Results identify five genes that are down-regulated by agouti signalling protein (ASIP), indicating a likely role for ASIP in human melanogenesis.

12. Agouti mRNA levels significantly elevated in type 2 diabetes. Insulin did not regulate agouti mRNA. Agouti can regulate adipogenesis.There are functional consequences of elevated agouti levels in human adipose tissue.

13. Our study suggests that the ASIP G>A polymorphism exhibits a dominant effect leading to lighter skin color and that variation in the ASIP gene may have been one of several factors contributing to reductions in pigmentation in some populations.

14. ASIP polymorphism was not associated with pigmentation, nevi, or melanoma risk

15. An important role for exon 17b of ASIP in cancer cells was identified;alternative splicing isoforms ,hASIP-sa, hASIP-sb, had different effects on cell growth and Fas/FasL-mediated apoptosis in BEL-7404 human hepatoma cells.

16. A/G polymorphism in the 3'-UTR region of the agouti signaling protein contributes to dark pigmentation.

17. Cocaine- and amphetamine-regulated transcript protein is colocalized with this protein and neuropeptide Y in human hypothalamus.

18. ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.

19. Two coding variants in TPCN2 are associated with hair color, and a variant at the ASIP locus shows strong association with skin sensitivity to sun, freckling and red hair.

20. ASIP polymorphism was found not to be associated with skin malignant melanoma or basal cell carcinoma.

Cow (Bovine) Agouti Signaling Protein (ASIP) interaction partners

1. Our results provide evidence for a widespread expression of ASIP in bovine tissues at mRNA and, for the first time, at protein level.

2. Possible consequences of Abr (agouti gene mutated by insertion of LINE element)for meat and milk production in cattle.

Pig (Porcine) Agouti Signaling Protein (ASIP) interaction partners

1. Mutational analysis of the ASIP loci in relation to coat color.

Horse (Equine) Agouti Signaling Protein (ASIP) interaction partners

1. variation in MC1R, ASIP, and MATP genes in horse coat color

2. there was a correlation between the recessive ASIP allele and a more independent temperament