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ASIP expression is significantly downregulated in human masticatory mucosa during wound healing
Polymorphisms of ASIP were found to be associated with skin, hair, and eye color in a phenotypically diverse Brazilian population. More research is needed to determine its usefulness in forensic science.
ASIP gene mutation is involved in the development of facial pigmented lesions.
Data show that ASIP TG/TG diplotype, which is known to be associated with melanoma risk, was linked to a 5-fold increase in hazard of death from melanoma.
An increased risk of melanoma (odds ratio [OR] 1.27, 95% confidence interval [95% CI] 1.03-1.57) in carriers of the rs4911414 variant, located 120 kb upstream of ASIP.
By using a population-based material of high-risk melanoma cases, we demonstrate a significant effect of both MC1R red hair color (RHC) variants and an ASIP haplotype, but could not replicate an association with postulated risk SNPs of TYR and TYRP1.
Findings suggest that ASIP locus is associated with a number of non-melanoma skin cancers.
Further analysis of binding and functional data suggests that the ASIP C-terminal loop (a six-amino-acid segment closed by the final disulfide bond) is essential for high-affinity MC1R binding and inverse agonism.
polymorphism in the agouti signaling protein gene is associated with human pigmentation
results show that men and women of similar age and BMI present similar agouti signal protein mRNA levels in omental and subcutaneous abdominal adipocytes but a sexual dimorphism exists in the relationship between its expression and BMI
Results identify five genes that are down-regulated by agouti signalling protein (ASIP), indicating a likely role for ASIP in human melanogenesis.
Agouti mRNA levels significantly elevated in type 2 diabetes. Insulin did not regulate agouti mRNA. Agouti can regulate adipogenesis.There are functional consequences of elevated agouti levels in human adipose tissue.
Our study suggests that the ASIP G>A polymorphism exhibits a dominant effect leading to lighter skin color and that variation in the ASIP gene may have been one of several factors contributing to reductions in pigmentation in some populations.
ASIP polymorphism was not associated with pigmentation, nevi, or melanoma risk
An important role for exon 17b of ASIP in cancer cells was identified;alternative splicing isoforms ,hASIP-sa, hASIP-sb, had different effects on cell growth and Fas/FasL-mediated apoptosis in BEL-7404 human hepatoma cells.
A/G polymorphism in the 3'-UTR region of the agouti signaling protein contributes to dark pigmentation.
Cocaine- and amphetamine-regulated transcript protein is colocalized with this protein and neuropeptide Y in human hypothalamus.
ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.
Two coding variants in TPCN2 are associated with hair color, and a variant at the ASIP locus shows strong association with skin sensitivity to sun, freckling and red hair.
ASIP polymorphism was found not to be associated with skin malignant melanoma or basal cell carcinoma.
Our results provide evidence for a widespread expression of ASIP in bovine tissues at mRNA and, for the first time, at protein level.
Possible consequences of Abr (agouti gene mutated by insertion of LINE element)for meat and milk production in cattle.
Mutational analysis of the ASIP loci in relation to coat color.
variation in MC1R, ASIP, and MATP genes in horse coat color
there was a correlation between the recessive ASIP allele and a more independent temperament
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
agouti signaling protein, nonagouti homolog
, agouti switch protein
, agouti-signaling protein
, nonagouti homolog
, Agouti (coat color)
, agouti signalling protein
, agouti signaling protein
, agouti-signaling protein-like
, Agouti switch protein
, Agouti-signaling protein