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ASIP antibody (AA 23-112)

ASIP Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7143597
  • Target See all ASIP Antibodies
    ASIP (Agouti Signaling Protein (ASIP))
    Binding Specificity
    • 6
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 23-112
    Reactivity
    • 24
    • 2
    Human
    Host
    • 25
    Rabbit
    Clonality
    • 25
    Polyclonal
    Conjugate
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ASIP antibody is un-conjugated
    Application
    • 15
    • 8
    • 4
    • 3
    • 2
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Agouti-signaling protein (23-112AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    ASIP (Agouti Signaling Protein (ASIP))
    Alternative Name
    ASIP (ASIP Products)
    Synonyms
    AGSW antibody, AGTI antibody, AGTIL antibody, ASP antibody, SHEP9 antibody, ASIP antibody, AA960621 antibody, AI256638 antibody, D8Ertd580e antibody, PAR-3 antibody, Par3 antibody, Pard3a antibody, agouti signaling protein antibody, par-3 family cell polarity regulator antibody, ASIP antibody, Asip antibody, asip antibody, Pard3 antibody
    Background

    Background: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

    Aliases: ASIP antibody, AGTI antibody, AGTIL antibody, ASP antibody, Agouti-signaling protein antibody, ASP antibody, Agouti switch protein antibody

    UniProt
    P42127
    Pathways
    Cell-Cell Junction Organization, Feeding Behaviour
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