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anti-Human Claudin 1 Antibodies:
anti-Mouse (Murine) Claudin 1 Antibodies:
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Human Monoclonal Claudin 1 Primary Antibody for IHC (p), IP - ABIN563931
Mee, Grove, Harris, Hu, Balfe, McKeating: Effect of cell polarization on hepatitis C virus entry. in Journal of virology 2007
Show all 16 Pubmed References
Human Polyclonal Claudin 1 Primary Antibody for WB - ABIN2801934
Halford, Spencer, Greenwood, Winton, Hunt, Adamson: Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids. in Cytogenetics and cell genetics 2000
Show all 4 Pubmed References
Human Polyclonal Claudin 1 Primary Antibody for IHC (p), ELISA - ABIN545827
Paschoud, Bongiovanni, Pache, Citi: Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007
Show all 3 Pubmed References
Human Polyclonal Claudin 1 Primary Antibody for ELISA, WB - ABIN545828
Morohashi, Kusumi, Sato, Odagiri, Chiba, Yoshihara, Hakamada, Sasaki, Kijima: Decreased expression of claudin-1 correlates with recurrence status in breast cancer. in International journal of molecular medicine 2007
Show all 3 Pubmed References
Human Polyclonal Claudin 1 Primary Antibody for ELISA, ICC - ABIN4298947
Dietze, Shihan, Stammler, Konrad, Scheiner-Bobis: Cardiotonic steroid ouabain stimulates expression of blood-testis barrier proteins claudin-1 and -11 and formation of tight junctions in Sertoli cells. in Molecular and cellular endocrinology 2015
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Human Monoclonal Claudin 1 Primary Antibody for CyTOF, FACS - ABIN4898991
Farquhar, Hu, Harris, Davis, Brimacombe, Fletcher, Baumert, Rappoport, Balfe, McKeating: Hepatitis C virus induces CD81 and claudin-1 endocytosis. in Journal of virology 2012
Show all 3 Pubmed References
Human Polyclonal Claudin 1 Primary Antibody for IF, IHC - ABIN6711703
González-Mariscal, Garay, Quirós: Identification of claudins by western blot and immunofluorescence in different cell lines and tissues. in Methods in molecular biology (Clifton, N.J.) 2011
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Mouse (Murine) Polyclonal Claudin 1 Primary Antibody for IHC, WB - ABIN3023187
Knowlton, Fernández de Castro, Ashbrook, Gestaut, Zamora, Bauer, Forrest, Frydman, Risco, Dermody: The TRiC chaperonin controls reovirus replication through outer-capsid folding. in Nature microbiology 2018
Human Polyclonal Claudin 1 Primary Antibody for IF (p), IHC (p) - ABIN686407
Wang, Chen, Liang, Yan, Lin, Liu, Luo, Huang, Li, Liu, Tang: Notch inhibition promotes fetal liver stem/progenitor cells differentiation into hepatocytes via the inhibition of HNF-1?. in Cell and tissue research 2014
CLDN1 is associated with tumorigenesis of human salivary gland tumors.
BHLHE40 suppressed CLDN1 transcription by preventing the interaction between SP1 and a specific motif within the promoter region of CLDN1.
our results suggest that the loss of claudin-1 expression significantly correlates with aggressive tumor behaviors in colorectal cancer
CLaudin-1 contributes to malignant potentials of cervical adenocarcinoma cells.Claudin-1 expression is regulated by GPR30 signaling in the cervical adenocarcinoma cells.
the accumulation and toxicity of doxorubicin were rescued by CLDN1 siRNA in A549R cells. We suggest that CLDN1 is upregulated by CDDP resistance through activation of a PI3K/Akt/NF-kappaB pathway, resulting in the inhibition of penetration of anticancer drugs into the inner area of spheroids
Our data indicate that CLDN1 targeting with an anti-CLDN1 mAb results in decreased growth and survival of CRC cells. This suggests that CLDN1 could be a new potential therapeutic target.
CLDN1 activates autophagy through up-regulation of ULK1 phosphorylation and promotes drug resistance of non-small cell lung cancer cells to cisplatin.
Human Growth Hormone Inhibits CLAUDIN-1 Expression Through Activation of Signal Transducer and Activator of Transcription 3 (STAT3).
CLDN1 promotes invasion and metastasis in cervical cancer cells via the expression of EMT/invasion-related genes.
Cycling hypoxia could induce significant changes in CLDN1 and CLDN7 expression in nasopharyngeal cancer cells, indirectly regulation P18 expression and affecting cell invasion/proliferation.
This study is the first to show a cytoplasmic function of claudin 1 as an autophagy regulator and provides the evidence that claudin 1-mediated autophagy regulation is an integral part of the mechanism by which claudin 1 regulates cancer progression.
Rab25 is amplified and enhances aggressiveness in luminal B cancers while in claudin-low tumors, Rab25 is lost indicating possible anti-tumor functions
association of genetic polymorphisms of claudin-1 with small vessel vascular dementia
Glutamine increased claudin-1 expression in the colonic mucosa of patients with irritable bowel syndrome.
CLDN-1 promoted the migration and EMT through the Notch signaling pathway.
In human lung tissue, Claudin-1 is higher in RBFOX3-positive cells than in RBFOX3-negative cells. Immunostaining and mRNA quantification revealed that protein levels, but not mRNA levels, of Claudin-1 are increased by RBFOX3.
Data show that miR-30a could bind to the 3'-untranslted region of Slug mRNA and increased expression of claudins, a family of tight junction transmembrane proteins.
These findings indicate a previously unrecognized mechanism that miR-142-5p, targeting CLDN1, plays an important role in Hashimoto's thyroiditis pathogenesis.
Here, the authors identified an interaction between claudin-1 and Sec24C, a cargo-sorting component of the coat protein complex II (COPII) vesicular transport system.
Aberrant expression of the tight junction molecules claudin-1 and zonula occludens-1 mediates cell growth and invasion in oral squamous cell carcinoma cells.
In SAMP10 mice, in addition to preventing a decrease in the naive T cell ratio, aging-associated skin thinning was suppressed histologically and the expression of representative tight junction genes, such as Claudin-1 and Zo-1, was increased.
Adherens as well as tight junction marker proteins were rapidly and consistently upregulated in both the germinal as well as the functional layer of the oral mucosa. This represents a previously unknown parameter of the epithelial radiation response to clinically relevant fractionation protocols. CONCLUSION: Fractionated irradiation significantly enhanced the expression of all proteins investigated. This study revealed a
Taken together, these results demonstrate that BTZ-induced claudin 1 expression may be a valuable therapeutic approach for AD.
Results suggest that TLR4-dependent claudin-1 internalization and secondary anion secretion contribute to irinotecan-induced diarrhea.
The data suggested that miR-29a may regulate tumor growth and migration by targeting CLDN1.
Data show that the spatiotemporal expression of claudin-1 is dysregulated in homeobox (Msx) genes Msx1d/d/Msx2d/d uteri.
Cldn-1 is a positive regulator of osteoblast proliferation and differentiation.
We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to correctly position CLDN1 in tight junctions.
MIR29 targets and reduces expression of CLDN1 and NKRF to increase intestinal permeability in inflammatory bowel disease.
Occludin and Claudin-1 expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis.
regulates intestinal epithelial homeostasis via regulation of Notch-signalling
Downregulation of Sirt1 and upregulation of the tight junction protein Claudin-1 by SIRT1-mediated epigenetic regulation in podocytes contributed to albuminuria.
Cldn1(-/-) mice exhibited the abnormal stratum granulosum formation and stratum corneum barrier defects.
miR-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1
Claudin-1 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, dark cell area.
we identified Cldn1, Cldn2 and Cldn11 as genes that discriminate between diverse types of M2 macrophages
The tight junction protein claudin-1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3
Mouse CLDN1 (mCLDN1) supported HCV genotype 2a infection with only moderate efficiency. indicating CLDN1 also contributes to the restricted species tropism of HCV. CLDN1 also contributes to the restricted species tropism of HCV.
dynamic behavior of paired strands of this protein in cell membranes
Thr203 of claudin-1 is required to enhance the barrier function of claudin-1-based tight junctions, probably via its phosphorylation and subsequent integration into tight junctions.
Xclaudin 1 is required for proper convergent extension movement during Xenopus gastrulation.
Expression in the rumen epithelium.
Tumor necrosis factor-alpha increases claudin-1, 4, and 7 expression in renal tubular cells, altering permeability and transepithelial electrical resistance.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
, senescence-associated epithelial membrane protein 1
, claudin 19
, claudin 1
, tight junction protein