Browse our anti-Claudin 1 (CLDN1) Antibodies

Human Claudin 1 (CLDN1) interaction partners

1. CLDN1 is associated with tumorigenesis of human salivary gland tumors.

2. BHLHE40 suppressed CLDN1 transcription by preventing the interaction between SP1 and a specific motif within the promoter region of CLDN1.

3. our results suggest that the loss of claudin-1 expression significantly correlates with aggressive tumor behaviors in colorectal cancer

4. CLaudin-1 contributes to malignant potentials of cervical adenocarcinoma cells.Claudin-1 expression is regulated by GPR30 signaling in the cervical adenocarcinoma cells.

5. the accumulation and toxicity of doxorubicin were rescued by CLDN1 siRNA in A549R cells. We suggest that CLDN1 is upregulated by CDDP resistance through activation of a PI3K/Akt/NF-kappaB pathway, resulting in the inhibition of penetration of anticancer drugs into the inner area of spheroids

6. Our data indicate that CLDN1 targeting with an anti-CLDN1 mAb results in decreased growth and survival of CRC cells. This suggests that CLDN1 could be a new potential therapeutic target.

7. CLDN1 activates autophagy through up-regulation of ULK1 phosphorylation and promotes drug resistance of non-small cell lung cancer cells to cisplatin.

8. Human Growth Hormone Inhibits CLAUDIN-1 Expression Through Activation of Signal Transducer and Activator of Transcription 3 (STAT3).

9. CLDN1 promotes invasion and metastasis in cervical cancer cells via the expression of EMT/invasion-related genes.

10. Cycling hypoxia could induce significant changes in CLDN1 and CLDN7 expression in nasopharyngeal cancer cells, indirectly regulation P18 expression and affecting cell invasion/proliferation.

11. This study is the first to show a cytoplasmic function of claudin 1 as an autophagy regulator and provides the evidence that claudin 1-mediated autophagy regulation is an integral part of the mechanism by which claudin 1 regulates cancer progression.

12. Rab25 is amplified and enhances aggressiveness in luminal B cancers while in claudin-low tumors, Rab25 is lost indicating possible anti-tumor functions

13. association of genetic polymorphisms of claudin-1 with small vessel vascular dementia

14. Glutamine increased claudin-1 expression in the colonic mucosa of patients with irritable bowel syndrome.

15. CLDN-1 promoted the migration and EMT through the Notch signaling pathway.

16. In human lung tissue, Claudin-1 is higher in RBFOX3-positive cells than in RBFOX3-negative cells. Immunostaining and mRNA quantification revealed that protein levels, but not mRNA levels, of Claudin-1 are increased by RBFOX3.

17. Data show that miR-30a could bind to the 3'-untranslted region of Slug mRNA and increased expression of claudins, a family of tight junction transmembrane proteins.

18. These findings indicate a previously unrecognized mechanism that miR-142-5p, targeting CLDN1, plays an important role in Hashimoto's thyroiditis pathogenesis.

19. Here, the authors identified an interaction between claudin-1 and Sec24C, a cargo-sorting component of the coat protein complex II (COPII) vesicular transport system.

20. Aberrant expression of the tight junction molecules claudin-1 and zonula occludens-1 mediates cell growth and invasion in oral squamous cell carcinoma cells.

Mouse (Murine) Claudin 1 (CLDN1) interaction partners

1. In SAMP10 mice, in addition to preventing a decrease in the naive T cell ratio, aging-associated skin thinning was suppressed histologically and the expression of representative tight junction genes, such as Claudin-1 and Zo-1, was increased.

2. Adherens as well as tight junction marker proteins were rapidly and consistently upregulated in both the germinal as well as the functional layer of the oral mucosa. This represents a previously unknown parameter of the epithelial radiation response to clinically relevant fractionation protocols. CONCLUSION: Fractionated irradiation significantly enhanced the expression of all proteins investigated. This study revealed a

3. Taken together, these results demonstrate that BTZ-induced claudin 1 expression may be a valuable therapeutic approach for AD.

4. Results suggest that TLR4-dependent claudin-1 internalization and secondary anion secretion contribute to irinotecan-induced diarrhea.

5. The data suggested that miR-29a may regulate tumor growth and migration by targeting CLDN1.

6. Data show that the spatiotemporal expression of claudin-1 is dysregulated in homeobox (Msx) genes Msx1d/d/Msx2d/d uteri.

7. Cldn-1 is a positive regulator of osteoblast proliferation and differentiation.

8. We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to correctly position CLDN1 in tight junctions.

9. MIR29 targets and reduces expression of CLDN1 and NKRF to increase intestinal permeability in inflammatory bowel disease.

10. Occludin and Claudin-1 expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis.

11. regulates intestinal epithelial homeostasis via regulation of Notch-signalling

12. Downregulation of Sirt1 and upregulation of the tight junction protein Claudin-1 by SIRT1-mediated epigenetic regulation in podocytes contributed to albuminuria.

13. Cldn1(-/-) mice exhibited the abnormal stratum granulosum formation and stratum corneum barrier defects.

14. miR-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1

15. Claudin-1 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, dark cell area.

16. we identified Cldn1, Cldn2 and Cldn11 as genes that discriminate between diverse types of M2 macrophages

17. The tight junction protein claudin-1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3

18. Mouse CLDN1 (mCLDN1) supported HCV genotype 2a infection with only moderate efficiency. indicating CLDN1 also contributes to the restricted species tropism of HCV. CLDN1 also contributes to the restricted species tropism of HCV.

19. dynamic behavior of paired strands of this protein in cell membranes

20. Thr203 of claudin-1 is required to enhance the barrier function of claudin-1-based tight junctions, probably via its phosphorylation and subsequent integration into tight junctions.

Xenopus laevis Claudin 1 (CLDN1) interaction partners

1. Xclaudin 1 is required for proper convergent extension movement during Xenopus gastrulation.

Cow (Bovine) Claudin 1 (CLDN1) interaction partners

1. Expression in the rumen epithelium.

Pig (Porcine) Claudin 1 (CLDN1) interaction partners

1. Tumor necrosis factor-alpha increases claudin-1, 4, and 7 expression in renal tubular cells, altering permeability and transepithelial electrical resistance.