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Cow (Bovine) Polyclonal CLDN17 Primary Antibody for IHC, WB - ABIN2778040
Katoh, Katoh: CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. in International journal of molecular medicine 2003
Show all 2 Pubmed References
The structural features of Cldn17 contributing to anion channel formation are presented in this work.
Claudin 17 expression was down-regulated in gastric cancer.
CLDN17, clustered with CLDN8 (show CLDN8 Antibodies) at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11.
, human CLDN17 gene for claudin-17