Browse our Vinculin Proteins (VCL)

Full name:: Vinculin Proteins (VCL)

On www.antibodies-online.com are 14 Vinculin (VCL) Proteins from 9 different suppliers available. Additionally we are shipping Vinculin Antibodies (207) and Vinculin Kits (49) and many more products for this protein. A total of 284 Vinculin products are currently listed.

Synonyms:: 9430097D22, AA571387, AI462105, AW545629, CG3299, CMD1W, CMH15, CT11081, DDBDRAFT_0186762, DDBDRAFT_0232320, DDB_0186762, DDB_0232320, Dmel\\CG3299, Dmvincp, EG:103B4.1, hm:zehn2160, im:6902790, LOC100228062, MV, MVCL, VCL, vcl-A, Vin, Vin2EF, vinc

list all proteins	Gene Name	GeneID	UniProt
	VCL	7414	P18206
	VCL	22330	Q64727
Rat VCL	VCL	305679	P85972
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Vinculin Proteins (VCL) by Origin

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Top referenced Vinculin Proteins

Human Vinculin Protein expressed in HEK-293 Cells - ABIN2735299 : Beppu, Sawai, Satoh, Mori, Kazami, Misawa, Shibuya, Ishibashi, Sogawa, Kado, Kodera, Nomura, Kuwabara: Autoantibodies against vinculin in patients with chronic inflammatory demyelinating polyneuropathy. in Journal of neuroimmunology 2015 (PubMed)

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Human Vinculin (VCL) interaction partners

ERalpha (show ESR1 Proteins) upregulates vinculin expression in breast cancer cells; Loss of vinculin promotes amoeboid features of cancer cells
We report that polyoma small T antigen leads to upregulation of tubulin (show TUBB Proteins) and vinculin in a time dependent manner with tubulin (show TUBB Proteins) expression being most significantly affected.
Differential phosphatidylinositol 4,5-diphosphate binding of vinculin isoforms promotes quasi-equivalent dimerization.
Study used an all-heavy-atom structure-based model to study vinculin activation by talin in a high-tension context mechanically driven by F-actin, showed that vinculin activation may proceed from an intermediate state stabilized by partial talin-vinculin association. There is a low-force regime and a high-force regime where vinculin activation is dominated by two different pathways with distinct responses to force.
Vinculin head-tail interaction is required on soft substrates to destabilize vinculin and talin in FAs (show FAS Proteins), and to allow hMSCs branching. Another module involves paxillin (show PXN Proteins) and FAK (show PTK2 Proteins), which soft substrates also destabilize, but independently of vinculin head-tail interaction. This multi-modularity may be key to allow a versatile response to complex biomechanical cues.
The central role of talin and vinculin in cell adhesions suggests that the disintegration of the tissue in atherosclerosis could be partially driven by downregulation of these genes, leading to loosening of cell-ECM (show MMRN1 Proteins) interactions and remodeling of the tissue.
East Asian common VCL variant p.Asp841His (D841H) was associated with sudden unexplained nocturnal death syndrome (SUNDS) in the Chinese Han population.
We identified mutations in VCL associated with Short segment Hirschsprung disease. Correction of this mutation in induced pluripotent stem cells using CRISPR/Cas9 editing, as well as the RET (show RET Proteins) G731del mutation that causes Hirschsprung disease with total colonic aganglionosis, restored enteric neural crest cell function.
This review discusses the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. [review]
Study predicted the structure of the MAPK1 (show MAPK3 Proteins)-vinculin binding interface using a combination of flexible docking and molecular dynamics simulations, and confirmed that the MAPK1 (show MAPK3 Proteins)-vinculin interaction is mechanically regulated, and implicated a change in the vinculin D3-D4 cleft size upon vinculin activation as the basis for the conformational selectivity of MAPK1 (show MAPK3 Proteins) binding toward open vinculin.

Zebrafish Vinculin (VCL) interaction partners

Study show that zebrafish contain two homologous vinculin isoforms, of which the sequence of key functional domains is conserved with several higher vertebrate. Loss of both zygotic vcla and maternal contribution of vcla did not result in notable defects, while the additional loss of zygotic vclb is lethal only after embryonic stages. These data indicate that embryonic development in zebrafish can occur without vinculin.

Pig (Porcine) Vinculin (VCL) interaction partners

Results suggest that myosin VI (show MYO6 Proteins) and vinculin form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia.

Mouse (Murine) Vinculin (VCL) interaction partners

Vinculin-M94I resulted in 37% reduction in peak sodium current compared to wild type and the combination of Vinculin-M94I and pH 7.0 decreased peak sodium current.
Lipid binding increases vinculin activation and turnover at focal adhesions.
results suggest that the vinculin-actin interaction participates in FA-mediated mechanotransduction
These results suggest that vinculin promotes the nuclear localization of transcription factor TAZ (show TAZ Proteins) to inhibit the adipocyte differentiation on rigid extracellular matrix.
The results indicate that lipid rafts play an important role in extracellular matrix stiffness regulation of cell migration via expression vinculin and its interaction with vinexin alpha (show Sorbs3 Proteins).
Binding of vinculin to the R1-R3 region of the talin rod is important for focal adhesion stability.
These data demonstrate that Src-mediated phosphorylation is necessary for vinculin activation, and that phosphorylation controls cytoskeletal mechanics by regulating force transmission between the actin cytoskeleton and focal adhesion proteins.
results suggest that vinculin promotes directionally persistent cell migration and tension-dependent ECM (show MMRN1 Proteins) remodeling in complex 3D environments by increasing cell-ECM (show MMRN1 Proteins) adhesion and traction force generation.
Force-dependent conformational switch of alpha-catenin (show CTNNA1 Proteins) controls vinculin binding.
Mutant vinculin expressing cells are altered in cell migration, which is accompanied by changes in cell adhesion.

Fruit Fly (Drosophila melanogaster) Vinculin (VCL) interaction partners

These findings demonstrate the crucial importance of the tight control of the activity of vinculin.

Rabbit Vinculin (VCL) interaction partners

Syndecan-4 (show SDC4 Proteins) acts as a central mediator that bridges fibronectin (show FN1 Proteins), integrin and intracellular components (actin and vinculin) and once silenced, the cytoskeleton protein network is disrupted, highlighting Syn4 (show SNTG1 Proteins) relevance for balanced cell behavior.

Vinculin (VCL) Protein Profile

Protein Summary

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Alternative names and synonyms associated with Vinculin (VCL)

vinculin (VCL)
vinculin a (vcla)
vinculin A (vinA)
vinculin (Vcl)
Vinculin (Vinc)
vinculin (CpipJ_CPIJ013873)
vinculin (Bm1_37935)
vinculin (vcl)
vinculin S homeolog (vcl.S)

9430097D22 protein
AA571387 protein
AI462105 protein
AW545629 protein
CG3299 protein
CMD1W protein
CMH15 protein
CT11081 protein
DDBDRAFT_0186762 protein
DDBDRAFT_0232320 protein
DDB_0186762 protein
DDB_0232320 protein
Dmel\\CG3299 protein
Dmvincp protein
EG:103B4.1 protein
hm:zehn2160 protein
im:6902790 protein
LOC100228062 protein
MV protein
MVCL protein
VCL protein
vcl-A protein
Vin protein
Vin2EF protein
vinc protein

Protein level used designations for Vinculin Proteins (VCL)

metavinculin , vinculin , CG3299-PA , Vinc-PA , vinculin at 2EF , vinculin-like , vinculin/metavinculin

GENE ID	SPECIES
7414	Homo sapiens
783645	Bos taurus
450531	Pan troglodytes
552980	Danio rerio
396974	Sus scrofa
8625369	Dictyostelium discoideum AX4
22330	Mus musculus
31201	Drosophila melanogaster
305679	Rattus norvegicus
396422	Gallus gallus
6047004	Culex quinquefasciatus
6102471	Brugia malayi
100036705	Xenopus (Silurana) tropicalis
100064165	Equus caballus
100228062	Taeniopygia guttata
100357160	Oryctolagus cuniculus
100410985	Callithrix jacchus
100476722	Ailuropoda melanoleuca
479252	Canis lupus familiaris
721921	Macaca mulatta
100075715	Ornithorhynchus anatinus
100302597	Meleagris gallopavo
100583187	Nomascus leucogenys
100722183	Cavia porcellus
373770	Xenopus laevis
101121312	Ovis aries

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Show all Vinculin Proteins (VCL) with Pubmed References