Browse our anti-Aurora Kinase C (AURKC) Antibodies

Human Aurora Kinase C (AURKC) interaction partners

1. The data suggest that AKA (show NEUROG1 Antibodies) is the vertebrate ancestral gene, and that AKB and AKC resulted from gene duplication in placental mammals.

2. Two novel DMRs, located in RPS6KA4/MIR1237 and the AURKC promoter, were found to be hypermethylated in WT

3. Identification and characterization of AURKB (show AURKB Antibodies) and AURKC variants associated with maternal aneuploidy has been reported.

4. Aurora-C interactions with members of the Chromosome Passenger Complex (CPC), Survivin (show BIRC5 Antibodies) and Inner Centromere Protein (INCENP (show INCENP Antibodies)) in reference to known Aurora-B (show AURKB Antibodies) interactions to understand the functional significance of Aurora-C overexpression in human cancer cells, is reported.

5. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2 (show DPY19L2 Antibodies).

6. Homozygous c.144delC mutation in AURKC gene in infertile men with macrozoospermia in the Tunisian population

7. AURKC mutations are more frequent than Klinefelter syndrome and constitute the leading genetic cause of infertility in North African men.

8. Low AURKC expression is associated with cancer.

9. Overexpression of AURKC is associated with breast tumors.

10. Data indicate that the selective Aurora A (show AURKA Antibodies), B, and C inhibitor SAR156497 showed antineoplastic activity in HCT116 cell xenograft model.

Mouse (Murine) Aurora Kinase C (AURKC) interaction partners

1. findings demonstrate that maternal RNAs regulate AURKC localization and activity in mouse oocytes

2. The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB (show AURKB Antibodies) or AURKC using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA (show AURKA Antibodies) expression is crucial for spindle formation in meiosis

3. Three of these mutations AURKC c.144delC (AURKC p.L49Wfs22), AURKC c.686G > A (AURKC p.C229Y) and AURKC c.744C > G (AURKC p.Y248*) are the focus of this study. AURKC p.L49Wfs22 is a loss-of-function mutant that perturbs localization of the chromosomal passenger complex (CPC), AURKC p.C229Y is a hypomorph that cannot fully support cell-cycle progression, and AURKC p.Y248* fails to support chromosome segregation.

4. These data uncover a role for haspin (show GSG2 Antibodies) as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers in oocytes.

5. these data suggest that mammalian oocytes contain AURKC to efficiently execute meiosis I and ensure high-quality eggs necessary for sexual reproduction.

6. These findings suggest a model for the presence of AURKC in oocytes: that AURKC compensates for loss of AURKB (show AURKB Antibodies) through differences in both message recruitment and protein stability.

7. Overexpressed Aurora-C (aurkc) is an oncogene (show RAB1A Antibodies). Overexpression of Aurora-C induces abnormal cell division resulting in centrosome amplification and multinucleation. Cells overexpressing active Aurora-C induced tumour formation.

8. Conditional deletion of aurora B in somatic cells that do not express aurora C results in chromosomal misalignment and lack of chromosome segregation.

9. Aurora-C, but not Aurora-B, plays essential roles in female mouse meiosis.

10. role in regulating the cleavage furrow-specific vimentin (show VIM Antibodies) phosphorylation in the cytokinetic process

Cow (Bovine) Aurora Kinase C (AURKC) interaction partners

1. AURKB (show AURKB Antibodies), AURKC, and Thr (show TRH Antibodies)-phosphorylated AURKA (show AURKA Antibodies) were detected at a contractile ring/midbody during the first polar body extrusion.