Browse our anti-CDC25A (CDC25A) Antibodies

Full name:: anti-Cell Division Cycle 25 Homolog A (S. Pombe) Antibodies (CDC25A)

On www.antibodies-online.com are 474 Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) Antibodies from 30 different suppliers available. Additionally we are shipping CDC25A Proteins (10) and CDC25A Kits (5) and many more products for this protein. A total of 536 CDC25A products are currently listed.

Synonyms:: cdc25A, CDC25A2, D9Ertd393e, sb:cb317

list all antibodies	Gene Name	GeneID	UniProt
	CDC25A	993	P30304
	CDC25A	171102	P48965
	CDC25A	12530
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Most Popular Reactivities for anti-CDC25A (CDC25A) Antibodies

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anti-Human CDC25A Antibodies:

anti-Rat (Rattus) CDC25A Antibodies:

anti-Mouse (Murine) CDC25A Antibodies:

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Relevant Pathways for anti-CDC25A Antibodies

M Phase

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Top referenced anti-CDC25A Antibodies

Human Polyclonal CDC25A Primary Antibody for IHC (p), WB - ABIN1881188 : Ito, Yoshida, Matsuzuka, Matsuura, Nakamura, Nakamine, Kakudo, Kuma, Miyauchi: Cdc25A and cdc25B expression in malignant lymphoma of the thyroid: correlation with histological subtypes and cell proliferation. in International journal of molecular medicine 2004 (PubMed)
Show all 15 Pubmed References
Human CDC25A Primary Antibody for IHC - ABIN965831 : Shimuta, Nakajo, Uto, Hayano, Okazaki, Sagata: Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition. in The EMBO journal 2002 (PubMed)
Show all 2 Pubmed References
Human Polyclonal CDC25A Primary Antibody for IHC - ABIN965832 : Jin, Shirogane, Xu, Nalepa, Qin, Elledge, Harper: SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. in Genes & development 2003 (PubMed)
Show all 2 Pubmed References
Human Polyclonal CDC25A Primary Antibody for IHC (p), WB - ABIN389532 : Chou, Yen, Lee, Chen: Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain. in The Journal of biological chemistry 2010 (PubMed)
Show all 3 Pubmed References
Human Polyclonal CDC25A Primary Antibody for IF (p), IHC (p) - ABIN680263 : Wei, Zhang, Ren, Zhang, Liu, Duan, Yu, Li, Peng, Zhou, Sun: Endosulfan induces cell dysfunction through cycle arrest resulting from DNA damage and DNA damage response signaling pathways. in The Science of the total environment 2017 (PubMed)
Human Polyclonal CDC25A Primary Antibody for IP, WB - ABIN151568 : Zou, Ai, Wang, Yuan, Yan, Zheng: The role of Med19 in the proliferation and tumorigenesis of human hepatocellular carcinoma cells. in Acta pharmacologica Sinica 2011 (PubMed)
Human Polyclonal CDC25A Primary Antibody for IHC, WB - ABIN362128 : Piao, Lee, Xu, Gwak, Oh, Park, Ha: CK1ε targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation. in Cell cycle (Georgetown, Tex.) 2011 (PubMed)
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Human Polyclonal CDC25A Primary Antibody for EIA, IHC (p) - ABIN358093 : Nemoto, Vogt, Oguri, Lazo: Activation of the Raf-1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells. in The Prostate 2003 (PubMed)
Show all 6 Pubmed References
Human Polyclonal CDC25A Primary Antibody for IHC (p), WB - ABIN390214 : Chow, Siu, Fung, Chan, Lau, Arooz, Ng, Yamashita, Poon: DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase. in Molecular biology of the cell 2003 (PubMed)
Show all 2 Pubmed References
Human Polyclonal CDC25A Primary Antibody for IHC (p), WB - ABIN389531 : Neumann, Yang, Köhler, Giaisi, Witzens-Harig, Liu, Krammer, Lin, Li-Weber: Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest. in International journal of cancer. Journal international du cancer 2015 (PubMed)
Show all 2 Pubmed References

More Antibodies against CDC25A Interaction Partners

Zebrafish Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) interaction partners

Stat3 (show STAT3 Antibodies) regulates cell proliferation and axis extension in part via upregulation of Cdc25a expression during oogenesis. Accordingly, restoring Cdc25a expression in stat3 (show STAT3 Antibodies) mutants partially suppressed cell proliferation and gastrulation defects.

Human Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) interaction partners

Inhibition of YBX1 suppressed lung cancer growth partly via the CDC25a pathway and high expression of YBX1/CDC25a predicts poor prognosis in human lung adenocarcinoma.
MCPH1 (show MCPH1 Antibodies) interacts with and promotes the E3 ligase betaTrCP2 to degrade Cdc25A independent of DNA damage. Overexpression of betaTrCP2 or the knockdown of Cdc25A remedies the high mitotic index and rescues the premature differentiation of Mcph1 (show MCPH1 Antibodies)-deficient neuroprogenitors in vivo MCPH1 (show MCPH1 Antibodies) itself is degraded by APC (show APC Antibodies)/CCdh1, but not APC (show APC Antibodies)/CCdc20, in late mitosis and G1 phase.
The cytoplasmic relocalization of CDC25A in skin cancers results in acquisition of an antiapoptotic function for CDC25A.
NPAS2 has a critical role in HCC cell survival and tumor growth, which is mainly mediated by transcriptional upregulation of CDC25A.
Results identify cyclinD-CDK4/6 complexes as novel regulators of CDC25A stability during G1 phase, generating a negative feedback loop allowing control of the G1/S transition.
These results identify a new positive regulatory loop between Cdc25A and its CDK-cyclin substrates which contributes to accelerate entry into mitosis through the regulation of Cdc25A activity in G2.
The expression level of Cdc25A was significantly increased (<0.05) after treatment with miR (show MLXIP Antibodies)-675 mimics.
miR-497 modulates the growth of chondrosarcoma cells by targeting Cdc25A.
This study demonstrated that the cell cycle pathway and the cdc25a gene may be crucial in the pathogenesis and progression of hepatocellular carcinoma.
Increased CDC25A is associated with invasiveness in Non-small Cell Lung Cancer.

Mouse (Murine) Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) interaction partners

Our results identify Cdc25A as a potential target for neuroprotectant strategy for the treatment of delayed ischemic neuronal death.
CDC25A-deficient embryonic stem cells resist high doses of ATR inhibitors, which we show is due to their failure to prematurely enter mitosis in response to the drugs.
These results showed that IGF1 regulated the expression of BOULE and CDC25A mRNAs via ERK1/2 signaling and in T-independent pathway during spermatogenesis in the adult mouse testes.
accelerated cholangiocyte cystogenesis is likely due to overexpression of Cdc25A
Cdc25A activity is required for the metaphase II arrest in mouse oocytes.
deletion of Cdc25a increased apoptosis and accelerated the elimination of DNA damage following UV
In the DNA damage response, instead of inhibiting cyclin B-CDK1 (show CDK1 Antibodies) through destruction of Cdc25A phosphatase, oocytes utilize an inhibitory phosphorylation of Cdc25B (show CDC25B Antibodies).
Cdc25A inhibitors block cell-cycle progression and proliferation, reduce liver and kidney weights and cyst growth in animal models of polycystic kidney/liver disease.
CDC25A and CDC25B (show CDC25B Antibodies) but not CDC25C (show CDC25C Antibodies) compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells
IL-7 (show IL7 Antibodies) drives Cdc25A-mediated T-cell proliferation, which prevents the nuclear translocation of Foxo1 (show FOXO1 Antibodies), leading to reduced expression of CD62L (show SELL Antibodies) and the migration of T cells into circulation.

Xenopus laevis Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) interaction partners

Cdc25A is a key player in the developmentally regulated program of apoptosis in X. laevis embryos
Strong ERK (show MAPK1 Antibodies) activation can target Cdc25A for degradation in a manner similar to, but independent of, Chk1 (show CHEK1 Antibodies) for cell cycle arrest.

CDC25A Antigen Profile

Antigen Summary

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CDC25A

cell division cycle 25A (CDC25A) antibody
cell division cycle 25A (cdc25a) antibody
cell division cycle 25B (cdc25b) antibody
cell division cycle 25A (Cdc25a) antibody
cell division cycle 25A S homeolog (cdc25a.S) antibody

cdc25A antibody
CDC25A2 antibody
D9Ertd393e antibody
sb:cb317 antibody

Protein level used designations for CDC25A

cell division cycle 25A , cell division cycle 25 homolog A , M-phase inducer phosphatase 1 , Dual specificity phosphatase Cdc25A , CDC25A2-CAG isoform , dual specificity phosphatase CDC25A , dual specificity phosphatase Cdc25A

GENE ID	SPECIES
460341	Pan troglodytes
733851	Xenopus (Silurana) tropicalis
57925	Danio rerio
420375	Gallus gallus
484780	Canis lupus familiaris
520188	Bos taurus
100064223	Equus caballus
993	Homo sapiens
171102	Rattus norvegicus
12530	Mus musculus
734734	Xenopus laevis

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Show all anti-Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) Antibodies with Pubmed References