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anti-Human CDC25B Antibodies:
anti-Mouse (Murine) CDC25B Antibodies:
anti-Rat (Rattus) CDC25B Antibodies:
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Mouse (Murine) Polyclonal CDC25B Primary Antibody for WB - ABIN871399
Li, Park, Liang, Zhao: Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R. in Retrovirology 2010
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Human Polyclonal CDC25B Primary Antibody for IHC (p), WB - ABIN391380
Uchida, Ohtsubo, Shimura, Hirata, Nakagama, Matsunaga, Yoshida, Ishizaka, Yamashita: Nuclear export signal in CDC25B. in Biochemical and biophysical research communications 2004
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miR (show MLXIP Antibodies)-152 was a tumor suppressor in EC that inhibited proliferation of human endometrial cancer cells via inducing G2/M phase arrest by suppressing CDC25B expression.
High CDC25B expression is associated with non-small cell lung cancer metastasis.
YWHAE (show YWHAE Antibodies) silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC (show MYC Antibodies) in gastric cancer cells.
our study demonstrate that KCTD12 (show KCTD12 Antibodies) binds to CDC25B and activates CDK1 (show CDK1 Antibodies) and Aurora A (show AURKA Antibodies) to facilitate the G2/M transition and promote tumorigenesis and that Aurora A (show AURKA Antibodies) phosphorylates KCTD12 (show KCTD12 Antibodies) at serine 243 to trigger a positive feedback loop, thereby potentiating the effects of KCTD12 (show KCTD12 Antibodies). Thus, the KCTD12 (show KCTD12 Antibodies)-CDC25B-CDK1 (show CDK1 Antibodies)-Aurora A (show AURKA Antibodies) axis has important implications for cancer diagnoses and prognoses.
While the low expression level of DUSP7 (show DUSP7 Antibodies) was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of CDC25B correlated with the activity of early arthritis.
Conformational flexibility of the complete catalytic domain of Cdc25B phosphatase has been demonstrated.
Data indicate that nine compounds were identified with Ki values for CDC25A, -B and -C ranging from 0.01 to 4.4 muM.
High CDC25B expression is associated with esophageal carcinoma.
Solution NMR studies reveal no global flexibility in the structure of CDC25b catalytic domain
For the first time, we demonstrate that miRNA-211 is a direct negative regulator of CDC25B expression in TNBC cells, alters other related target proteins CCNB1 (show CCNB1 Antibodies) and FOXM1 (show FOXM1 Antibodies), and then inhibits breast cancer cells growth, migration, and invasion
data suggest an important role of CDC25B for microtubule nucleation and organization. N-terminal of CDC25B is required for regulating the microtubule dynamics and mitotic function.
LSD1 (show KDM1A Antibodies) is essential for oocyte meiotic progression by upregulating CDC25B expression.
The role of Cdc25c (show CDC25C Antibodies) and Cdc25b in activating G2/M cell cycle checkpoint in zygote.
AURKA (show AURKA Antibodies) induced phosphorylation and recruitment of CDC25B to MTOCs prior to p-Cyclin B1 (show CCNB1 Antibodies)-Ser123, and this sequential regulation is essential for the commitment of the oocytes to resume meiosis.
Data indicate that 14-3-3epsilon is required for the mitotic entry in the fertilized mouse eggs and responsible for sequestering the CDC25B in cytoplasm. Its binding to CDC25B-S321 phosphorylated by PKA induces mitotic arrest.
Ser321 of Cdc25B is the specific binding site for 14-3-3epsilon binding.
Protein kinase A the early development of mouse embryos by phosphorylation of S149 and S321 of CDC25B, which plays an important role in the regulation of G(2)/M transition in the mitotic cell cycle of fertilized mouse eggs.
In the DNA damage response, instead of inhibiting cyclin B-CDK1 (show CDK1 Antibodies) through destruction of Cdc25A (show CDC25A Antibodies) phosphatase, oocytes utilize an inhibitory phosphorylation of Cdc25B.
Cdc25B overexpression in early mouse two-cell embryos reverses two-cell block and promotes their development into four-cell stage by activating MPF (show MSLN Antibodies).
MCPH1 (show MCPH1 Antibodies), through its function in the Chk1 (show CHEK1 Antibodies)-Cdc25 (show CDC25C Antibodies)-Cdk1 (show CDK1 Antibodies) pathway to couple the centrosome cycle with mitosis, is required for precise mitotic spindle orientation and thereby regulates the progenitor division mode to maintain brain size.
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.
cell division cycle 25 homolog B
, cell division cycle 25 homolog B (S. pombe)
, M-phase inducer phosphatase 2-like
, m-phase inducer phosphatase 2-like
, cell division cycle 25B
, M-phase inducer phosphatase 2
, dual specificity phosphatase Cdc25B