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anti-Human CDK9 Antibodies:
anti-Rat (Rattus) CDK9 Antibodies:
anti-Mouse (Murine) CDK9 Antibodies:
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Human Monoclonal CDK9 Primary Antibody for IHC, ELISA - ABIN965846
Montanuy, Torremocha, Hernández-Munain, Suñé: Promoter influences transcription elongation: TATA-box element mediates the assembly of processive transcription complexes responsive to cyclin-dependent kinase 9. in The Journal of biological chemistry 2008
Show all 2 Pubmed References
Human Monoclonal CDK9 Primary Antibody for IHC, ELISA - ABIN969042
Sabò, Lusic, Cereseto, Giacca: Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription. in Molecular and cellular biology 2008
Show all 2 Pubmed References
GRIP1 (show NCOA2 Antibodies) is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), which is recruited into GC-induced GR:GRIP1:CDK9 hetero-complexes, producing distinct GRE-specific GRIP1 (show NCOA2 Antibodies) phospho-isoforms.
Recent studies have highlighted the importance of CDK9 in many relevant pathologic processes, like cancer, cardiovascular diseases, and viral replication.
This shows that CDK9 stimulates release of paused polymerase and activates transcription by increasing the number of transcribing polymerases and thus the amount of mRNA synthesized per time.
this study suggests that CDK2 (show CDK2 Antibodies) and CDK9 are potential therapeutic targets in Neuroblastoma (show ARHGEF16 Antibodies) (NB) and that abrogating CDK2 (show CDK2 Antibodies) and CDK9 activity by small molecules like dinaciclib is a promising strategy and a treatment option for NB patients
miR (show MLXIP Antibodies)-206 is remarkably downregulated and is inversely correlated with CDK9 level in HCC (show FAM126A Antibodies) cells. It is evident that miR (show MLXIP Antibodies)-206 functions as a tumor suppressor through blocking CDK9-related pathway to induce apoptosis and inhibit HCC (show FAM126A Antibodies) cell proliferation.
this study shows role of CDK9 in oncogenic processes of esophageal adenocarcinoma
CDK9, in addition to CDK1 (show CDK1 Antibodies), has roles in mediating the growth inhibitory effect of dinaciclib on cyclin B1 (show CCNB1 Antibodies) in triple negative breast cancer
Cdk9 is a post-exposure drug target against human adenoviruses.
BRD4 (show BRD4 Antibodies) and CDK9 have independent, coordinated roles in promoting the myofibroblast transition
RBPJ (show RBPJ Antibodies) links MYC (show MYC Antibodies) and transcriptional control through CDK9 in brain tumors, providing potential nodes of fragility for therapeutic intervention, potentially distinct from NOTCH (show NOTCH1 Antibodies)
CDK9 clearly plays a fundamental role in early cellular growth and proliferation.
Pharmacological and genetic results present evidence that CDK9 is involved in the resolution of neutrophil-dependent inflammation.
The balance of Cdk9 and Larp7 (show LARP7 Antibodies) plays a key role in cardiomyocyte proliferation and response to injury
actin (show ACTB Antibodies) participates in transcription elongation by recruiting Cdk9,a catalytic subunit of P-TEFb, for phosphorylation of the Pol II C-terminal domain, and the actin (show ACTB Antibodies)-Cdk9 interaction promotes chromatin remodeling
Genetic transcription and RNA processing of PTefb kinase is coordinated on heat shock genes.
Cdk9 is required for heat shock gene expression, histone methylation and elongation factor (show TSFM Antibodies) recruitment.
Cdk9 plays a complex role in myocyte progenitor differentiation and apoptosis by regulating myogenic protein and muscle-specific (show EIF3K Antibodies) microRNA expression.
findings revealed the crucial role of CDK9/Cyclin T1 (show CCNT1 Antibodies)/Pol II (show 0 Antibodies) pathway in promoting allorejection at multiple levels and may provide a new approach for transplantation tolerance induction through targeting CDK9
identified cyclin-dependent kinase 9 (Cdk9) as required for hepatocellular carcinoma disease maintenance
This study demonstrates that Ikaros (show IKZF1 Antibodies) directly interacts with GATA1 (show GATA1 Antibodies), GATA2 (show GATA2 Antibodies), and GATA3 (show GATA3 Antibodies) as well as Cdk9/P-TEFb through specific protein domains.
Data show that the minimal 90-amino acid AF9 (show MLLT3 Antibodies) fragment in MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) retains an ability to form higher order complexes with AF4*P-TEFb (show CCNT1 Antibodies) and with DOT1 (show DOT1L Antibodies).
Data show that the CDK9 and cyclin T1 (show CCNT1 Antibodies) subunits of P-TEFb (show CCNT1 Antibodies) are present in mouse oocytes and preimplantation embryos, and that CDK9 is essential for embryonic genome activation in the mouse.
The present study examined whether Cdk9 forms a complex with GATA4 (show GATA4 Antibodies) in mouse embryonic stem cells and is involved in their differentiation into cardiomyocytes.
Data report that a second cdk9 isoform, termed cdk9-55, plays a fundamental role in muscle regeneration and differentiation in vivo.
role in activating MyoD (show MYOD1 Antibodies)-dependent transcription
inhibition of CDK9 abrogated global transcriptional activity and rRNA production. Collectively, our data suggested that P-TEFb (show CCNT1 Antibodies) kinase activity is crucial for oocyte maturation, embryo development and regulation of RNA transcription in pig.
Full-length cDNA, morpholinos, and mutagenesis rescue constructs of cdk9L were used. Cdk9.S, Cdk9.L andCyclinT1 were expressed in the neural plate and neural plate border of neurula stage embryos and in the neural-crest-derived branchial arteries at the tailbud stage. Cdk9 knockdown causes an increase in RNA Pol II (show 0 Antibodies) occupance and pausing of c-myc (show MYC Antibodies) which regulates neural crest specification.
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
, cell division cycle 2-like protein kinase 4
, cell division protein kinase 9
, serine/threonine protein kinase PITALRE
, serine/threonine-protein kinase PITALRE
, tat-associated kinase complex catalytic subunit
, cyclin-dependent kinase 9 (CDC2-related kinase)
, Cyclin-dependent kinase9 2.7
, p43 PITALRE
, positive transcription elongation factor b
, positive transcription elongation factor b, small subunit
, cyclin-dependent kinase 9
, cell division protein kinase 9-A
, cyclin-dependent kinase 9-A