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anti-Human FOXO3 Antibodies:
anti-Rat (Rattus) FOXO3 Antibodies:
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Human Polyclonal FOXO3 Primary Antibody for IHC - ABIN966151
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. in The Journal of cell biology 2005
Show all 5 Pubmed References
Human FOXO3 Primary Antibody for IHC - ABIN966150
Essafi, Fernández de Mattos, Hassen, Soeiro, Mufti, Thomas, Medema, Lam: Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. in Oncogene 2005
Show all 5 Pubmed References
Human Polyclonal FOXO3 Primary Antibody for ChIP, ICC - ABIN4312377
Sinanoglu, Yener, Ekici, Midi, Aksungar: The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. in Urology 2012
Show all 2 Pubmed References
Human Polyclonal FOXO3 Primary Antibody for IF, IHC - ABIN1355835
Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. in Cell 2006
Show all 5 Pubmed References
Human Polyclonal FOXO3 Primary Antibody for ELISA, WB - ABIN250244
Brunet, Bonni, Zigmond, Lin, Juo, Hu, Anderson, Arden, Blenis, Greenberg: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. in Cell 1999
Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152044
Yuan, Luo, Liu, Lou: Regulation of SIRT1 activity by genotoxic stress. in Genes & development 2012
Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152045
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. in Molecular pharmaceutics 2015
Dog (Canine) Polyclonal FOXO3 Primary Antibody for ELISA, WB - ABIN2473689
Dijkers, Birkenkamp, Lam, Thomas, Lammers, Koenderman, Coffer: FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. in The Journal of cell biology 2002
Human Polyclonal FOXO3 Primary Antibody for IF (p), IHC (p) - ABIN684718
Morales, Abrigo, Acuña, Santos, Bader, Brandan, Simon, Olguin, Cabrera, Cabello-Verrugio: Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. in Disease models & mechanisms 2016
Transcriptional factor PAX3 (PAX3 (show PAX3 Antibodies)) exerted its tumor suppressor function by inhibiting the activity of major signaling pathways and enhancing expression and activity of transcription factor forkhead box O3 protein (FOXO3a).
The result suggests that FOXO3 rs12212067 polymorphism does not play an important role in susceptibility to T. cruzi infection and/or chronic Chagas cardiomyopathy.
Overexpression of circ-Foxo3 decreased the interaction between Foxo3 and MDM2 (show MDM2 Antibodies), and repressed the function of MDM2 (show MDM2 Antibodies) in modulating poly-ubiquitination of Foxo3.
silencing FOXO3 diminishes bepridil- and trifluoperazine-induced apoptosis in triple-negative breast cancer cells
Combined treatment with gamma-irradiation (gammaIR) and a dual PI3K (show PIK3CA Antibodies)/mTOR (show FRAP1 Antibodies) inhibitor causes loss of stemness and of FoxO1 (show FOXO1 Antibodies)/3 proteins in p53 (show TP53 Antibodies)-proficient glioblastoma multiforme stem cells (GBM-SCs (show TWIST1 Antibodies)).
The authors found that transient TUBB3 (show TUBB3 Antibodies) activation, through ABCB1 (show ABCB1 Antibodies), in response to the stimulation of FOXO3a expression, significantly contributes to the cross-resistance of the paclitaxel-resistant cell population and consequently limits the efficacy of both agents where cancer cells have developed multiple resistance.
findings provide further evidence for the involvement of FoxO3 during terminal erythropoiesis and confirm the modulation of the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway as a potential therapeutic strategy for beta-thalassemia
The data reveal a previously unexplored function of FOXO3a in gastric cancer invasion by regulating proteins involved in extracellular matrix degradation and Epithelial-Mesenchymal Transition. FOXO3a may be of prognostic value and a potential therapeutic target in blocking tumor metastasis.
pro-apoptotic role of miR (show MLXIP Antibodies)-34a in PA-induced cholangiocyte lipoapoptosis in culture and in the liver
Ergosterol peroxide stimulated Foxo3 activity by inhibiting pAKT (show AKT1 Antibodies) and c-Myc (show MYC Antibodies) and activating pro-apoptotic protein Puma (show BBC3 Antibodies) and Bax (show BAX Antibodies) to induce HepG2 cancer cell death.
These results indicate that myostatin (show MSTN Antibodies) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (show NR3C1 Antibodies) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN (show PTEN Antibodies), FOXO3A and PKB (show AKT1 Antibodies) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL (show VHL Antibodies), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
Data indicate that forkhead box O3 (FoxO3) has a central role in the neuronal reprogramming susceptibility of cells, and the importance of FoxO3 appears to change during development.
These results suggest that lack of FXR (show NR1H4 Antibodies) impaired FoxO3a-mediated autophagy and in turn exacerbated alcohol-induced liver injury
data show that the GSK3B (show GSK3b Antibodies)-FOXO3 pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R (show IGF1R Antibodies) after partial hepatectomy.
BIM (show BCL2L11 Antibodies)-dependent death during CD8 (show CD8A Antibodies)(+) T-cell deletion is FOXO3 independent.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (show MUL1 Antibodies) FBXO32/atrogin-1 (show FBXO32 Antibodies) and its transcription factor FOXO3A.
MiR (show MLXIP Antibodies)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.
The Foxo3-Eomes (show EOMES Antibodies) pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (show HAND1 Antibodies) cell differentiation.
NO/protein kinase (show CDK7 Antibodies) G (PKG (show PRKG1 Antibodies))-dependent downregulation of PGC-1 alpha (show PPARGC1A Antibodies) and the ROS (show ROS1 Antibodies) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Antibodies) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (show ROS1 Antibodies)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like