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Human FOXO3 Primary Antibody for IHC - ABIN966150
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. in The Journal of cell biology 2005
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Human Polyclonal FOXO3 Primary Antibody for IHC - ABIN966151
Essafi, Fernández de Mattos, Hassen, Soeiro, Mufti, Thomas, Medema, Lam: Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. in Oncogene 2005
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Human Polyclonal FOXO3 Primary Antibody for IF, IHC - ABIN1355835
Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. in Cell 2006
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Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152045
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. in Molecular pharmaceutics 2015
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Human Polyclonal FOXO3 Primary Antibody for ChIP, ICC - ABIN4312377
Sinanoglu, Yener, Ekici, Midi, Aksungar: The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. in Urology 2012
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Human Polyclonal FOXO3 Primary Antibody for IF (p), IHC (p) - ABIN731168
Morales, Abrigo, Acuña, Santos, Bader, Brandan, Simon, Olguin, Cabrera, Cabello-Verrugio: Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. in Disease models & mechanisms 2016
Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152044
Yuan, Luo, Liu, Lou: Regulation of SIRT1 activity by genotoxic stress. in Genes & development 2012
Human Polyclonal FOXO3 Primary Antibody for ELISA, WB - ABIN250244
Brunet, Bonni, Zigmond, Lin, Juo, Hu, Anderson, Arden, Blenis, Greenberg: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. in Cell 1999
Dog (Canine) Polyclonal FOXO3 Primary Antibody for ELISA, WB - ABIN2473689
Dijkers, Birkenkamp, Lam, Thomas, Lammers, Koenderman, Coffer: FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. in The Journal of cell biology 2002
these results suggest that miR (show MLXIP Antibodies)-30b plays important roles in kynurenine-induced increase of FOXO3 expression
Authors found that miR (show MLXIP Antibodies)-629 negatively regulated FOXO3 protein expression and decreased the activity of a luciferase reporter construct containing the FOXO3 3'-untranslated region. These results show that miR (show MLXIP Antibodies)-629 regulates FOXO3 at the posttranscriptional level, resulting in enhanced cell proliferation and invasion of pancreatic carcinoma.
auranofin could regulate the Her2 (show ERBB2 Antibodies)/Akt (show AKT1 Antibodies)/FOXO3 signaling pathway in SKOV3 cells and be used as a potential antitumor agent considering the expression of MUC4 (show MUC4 Antibodies) in ovarian cancer patients.
FNDC5 (show FNDC5 Antibodies) gene interactions with candidate genes FOXOA3 and APOE (show APOE Antibodies)
Results indicate a mechanism for beta-arrestin1 (show ARRB1 Antibodies) in the regulation of the prostate cancer procession through inhibiting FOXO3a.
The findings of this study indicated that FoxO3a knockdown conferred neuroprotective effects after TBI through inhibiting the activation of neuronal autophagy.
Low FOXO3A expression is associated with cancer.
Data show that forkhead box O3 protein (FOXO3) silencing could inhibit mitophagy and mitochondrial dysfunction induced by manganese chloride (MnCl2).
Report an inverse relationship of age with human serum FOXO3A and SIRT3 (show SIRT3 Antibodies) levels.
FOXO3 longevity interactome on chromosome 6 has been described.
These results indicate that myostatin (show MSTN Antibodies) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (show NR3C1 Antibodies) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (show AKT1 Antibodies) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL (show VHL Antibodies), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
findings demonstrate that the mTORC2 (show CRTC2 Antibodies)/AKT (show AKT1 Antibodies)/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.
Melanoma dormancy in a mouse model is linked to GILZ (show TSC22D3 Antibodies)/FOXO3A-dependent quiescence of disseminated stem-like cells
data showed that Klotho (show KL Antibodies) protects Tac (show IL2RA Antibodies)-induced oxidative stress by negatively regulating the PI3K/AKT (show AKT1 Antibodies) pathway and subsequently enhancing FoxO3a-mediated MnSOD (show SOD2 Antibodies) expression.
miR (show MLXIP Antibodies)-34a might suppress the excessive autophagic activity in alveolar type II epithelial AT-II cells via targeting FoxO3 to reduce the damage of LPS (show TLR4 Antibodies)-induced Acute Lung Injury.
PPE effectively attenuated oxidative stress and ototoxicity by regulating FoxO3a, and may thus prove to be beneficial in protecting auditory cells from ototoxic drugs.
Results show that Foxo3a is depressed in the nucleus while autophagy is impaired, and NLRP3 (show NLRP3 Antibodies) inflammasome is activated in Kupffer cells (KCs). Over-expression of Foxo3a restores autophagy flux and attenuates activation of the NLRP3 (show NLRP3 Antibodies) inflammasome via promoting the transcription of Bim (show BCL2L11 Antibodies).
Data indicate that forkhead box O3 (FoxO3) has a central role in the neuronal reprogramming susceptibility of cells, and the importance of FoxO3 appears to change during development.
These results suggest that lack of FXR (show NR1H4 Antibodies) impaired FoxO3a-mediated autophagy and in turn exacerbated alcohol-induced liver injury
pro-apoptotic role of miR (show MLXIP Antibodies)-34a in PA-induced cholangiocyte lipoapoptosis in culture and in the liver
data show that the GSK3B-FOXO3 pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R (show IGF1R Antibodies) after partial hepatectomy.
NO/protein kinase (show CDK7 Antibodies) G (PKG (show PRKG1 Antibodies))-dependent downregulation of PGC-1 alpha and the ROS (show ROS1 Antibodies) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Antibodies) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (show ROS1 Antibodies)-induced apoptosis in mammalian cells.
FOXO1 (show FOXO1 Antibodies), 3, and 4 as well as their upstream regulator, AKT/p-AKT (show AKT1 Antibodies), was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like