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anti-Mouse (Murine) GADD45B Antibodies:
anti-Human GADD45B Antibodies:
anti-Rat (Rattus) GADD45B Antibodies:
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Cow (Bovine) Polyclonal GADD45B Primary Antibody for IHC, WB - ABIN2783334
Tornatore, Marasco, Dathan, Vitale, Benedetti, Papa, Franzoso, Ruvo, Monti: Gadd45 beta forms a homodimeric complex that binds tightly to MKK7. in Journal of molecular biology 2008
Show all 5 Pubmed References
Human Polyclonal GADD45B Primary Antibody for IHC (p) - ABIN759598
Haditsch, Anderson, Freewoman, Cord, Babu, Brakebusch, Palmer: Neuronal Rac1 is required for learning-evoked neurogenesis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Human Polyclonal GADD45B Primary Antibody for ICC, IF - ABIN4336943
Rizzardi, Rosener, Koopmeiners, Isaksson Vogel, Metzger, Forster, Marston, Tiffany, McCarthy, Turley, Warlick, Henriksen, Schmechel: Evaluation of protein biomarkers of prostate cancer aggressiveness. in BMC cancer 2014
investigated the functional effects of Coiled-Coil Domain Containing 80-loss-of-function during embryonic development and verified its interaction with gadd45beta2 in somitogenesis
regulated expression of gadd45beta genes in the anterior PSM is required for somite segmentation.
Gadd45a,b double-mutant mouse embryos display embryonic sublethality, deregulated ZGA gene expression, and developmental arrestrevealing an unexpected role of GADD45 proteins in embryonic two-cell stage regulation
High GADD45B expression is associated with cancer.
Results indicate a role for Gadd45b in stress-induced senescence and in tissue aging.
Using whole-body knockout mice as well as liver/hepatocyte-specific gain- and loss-of-function strategies, the authors revealed a role for liver GADD45beta in the coordination of liver fatty acid uptake, through cytoplasmic retention of FABP1, ultimately impacting obesity-driven hyperglycaemia.
This study indicates that PPAR alpha activation drives demethylation of the CpG islands of the Gadd45b promoter in the mouse liver and that epigenetic change at the Gadd45b promoter is critical for Gadd45b induction.
Data suggest that the increased expression of Gadd45beta induced by repeated administration of L-DOPA may be beneficial in patients with Parkinson's disease.
lower nucleus accumbens levels may affect Bdnf expression possibly leading to altered alcohol-drinking behavior
Gadd45b mediates the action of electroconvulsive shock-induced neural stem cell proliferation in the hippocampus.
Results suggest the possibility that differential Gadd45a, Gadd45b and Gadd45g expression during development affects neurons, contributing cortical evolution and diversity
Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3.
Modulation of the TGFbeta/NFkappaB/Gadd45b signaling pathway may provide a means to enhance the neuroprotective effect of Gadd45b in RGCs.
These results implicate Gadd45b as a learning-induced gene and a regulator of memory formation and are consistent with its potential role in active DNA demethylation in memory.
The data suggest that GADD45beta plays a complex role in regulating adaptive immunity and, depending on the model, either enhances or suppresses inflammation.
The current studies suggest that Gadd45b may be important for long-term hippocampus-dependent memory storage.
these data highlight a novel role for both Gadd45a and Gadd45b in myeloid innate immune functions by differential modulation of p38 and JNK signaling in granulocytes compared to macrophages.
Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.
defined separate Gadd45beta domains that mediated binding to CAR and transcriptional activation
The synergism between GADD45beta and C/EBPbeta may play an important role in cellular senescence in the aging articular cartilage.
Gadd45b was identified from coupling of methylation with gene expression data, shed light on the underlying mechanisms of cytosine demethylation under methyl-deficient conditions.
CAR may repress death of mouse primary hepatocytes by forming a GADD45B complex and repressing MKK7-mediated phosphorylation of JNK1
demonstrate the protective role of GADD45beta in sepsis and the results suggest that GADD45beta could be used as a novel therapeutic target to cure sepsis
Down-regulation of GADD45beta can reduce the colony-forming ability of PC9 cells, promote the cell apoptosis, and enhance the sensitivity of PC9 cells to gefitinib
Although GADD45B is elevated in prostate cancer tissues, levels of GADD45B in prostate tumor tissues are reduced at late stage of tumor invasion, and higher levels of GADD45B predict better survivals of prostate cancer patients.
The assessment of the interaction between GADD45beta and MKK7 and the elucidation of the recognition surfaces between DTP3 and MKK7 significantly advance the understanding of the mechanism underlying the inhibition of the GADD45beta/MKK7 interaction by DTP3 and pave the way to the design of small-molecule DTP3 analogues.
We propose a signaling cascade involving ARID1A, GADD45B and DUSP1 as mediators of the romidepsin effects in GCC cells.
present study provides evidence that variations in GADD45B rs2024144T, MAPK14 rs3804451A and GADD45A rs581000C may predict platinum-based chemotherapy toxicity outcomes in patients with advanced non-small cell lung cancer
These findings demonstrate that 19p13.3-GADD45B rs7354 variant and interaction between 19p13.3-GADD45B rs3783501 and 19q13.3-CD3EAP rs967591 may play a role in association with smoke-exposed lung cancer among Chinese.
We used a new approach to search for human genes repressed by small nucleic acids (microRNAs) expressed by a gammaherpesvirus (KSHV), which identified a gene called GADD45B as a target of microRNAs. Repression of GADD45B, which is expressed in response to DNA damage, benefited survival of infected cells in response to a DNA damage response. This information could be used to design new treatments for herpesvirus infections
Gadd45beta could be a suitable biomarker of cardiomyocytes apoptosis in newborns experiencing hypoxia in the first day of life, as its highest tissue immunoexpression around at the first six hours after birth.
Nrf2-Gadd45b signaling axis exhibited a protective role in antimony trioxide-induced cell apoptosis.
our data demonstrate that C/EBPbeta plays a central role in controlling Gadd45beta gene expression in articular chondrocytes
The gadd45b gene has both tumor suppressor and tumor promoter functions, dependent on the tissue/cell type and transforming event. (Review)
Gadd45B protects the liver through two entirely different processes: binding MKK7 to block damaging signal transduction or binding CAR to coactivate anabolic transcription. (Review)
as such may play an unappreciated role in tumorigenesis. The exact mechanism of GADD45B inactivation and overexpression requires further investigation. GADD45B could be a potential therapeutic target for CRC treatment in future
Cadmium chloride can induce DNA damage and increase expression levels of the gadd153 and gadd45beta promoters in HepG2 cells.
finding show there is an increased expression and decreased promoter binding of GADD45b in psychotic subjects.
GADD45beta is a novel pituitary tumor suppressor whose reexpression blocks proliferation, survival, and tumorigenesis
The association of GADD45beta expression and pathological grading of chondrosarcoma in the present study suggests that the immunohistochemical study of GADD45beta may be a specific diagnostic parameter for chondrosarcoma cell differentiation.
PXR activates the GADD45beta gene, increasing p38 MAPK phosphorylation, and leading HepG2 cells to change morphology and migrate.
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.
, growth arrest and DNA damage 45 beta
, Myeloid differentiation primary response protein MyD118
, growth arrest and DNA damage-inducible protein GADD45 beta
, growth arrest and DNA-damage-inducible protein GADD45 beta
, myeloid differentiation primary response gene 118
, myeloid differentiation primary response protein MyD118
, negative growth regulatory protein MyD118
, myeloid differentiation primary response
, growth arrest and DNA-damage-inducible 45 beta