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Cow (Bovine) Polyclonal GADD45B Primary Antibody for IHC, WB - ABIN2783334
Tornatore, Marasco, Dathan, Vitale, Benedetti, Papa, Franzoso, Ruvo, Monti: Gadd45 beta forms a homodimeric complex that binds tightly to MKK7. in Journal of molecular biology 2008
Show all 5 Pubmed References
Human Polyclonal GADD45B Primary Antibody for IF (p), IHC (p) - ABIN759596
Haditsch, Anderson, Freewoman, Cord, Babu, Brakebusch, Palmer: Neuronal Rac1 is required for learning-evoked neurogenesis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Human Polyclonal GADD45B Primary Antibody for ICC, IF - ABIN4336943
Rizzardi, Rosener, Koopmeiners, Isaksson Vogel, Metzger, Forster, Marston, Tiffany, McCarthy, Turley, Warlick, Henriksen, Schmechel: Evaluation of protein biomarkers of prostate cancer aggressiveness. in BMC cancer 2014
investigated the functional effects of Coiled-Coil Domain Containing 80 (show CCD80 Antibodies)-loss-of-function during embryonic development and verified its interaction with gadd45beta2 in somitogenesis
regulated expression of gadd45beta genes in the anterior PSM (show SH2B1 Antibodies) is required for somite segmentation.
Results indicate a role for Gadd45b in stress-induced senescence and in tissue aging.
Using whole-body knockout mice as well as liver/hepatocyte-specific gain- and loss-of-function strategies, the authors revealed a role for liver GADD45beta in the coordination of liver fatty acid uptake, through cytoplasmic retention of FABP1 (show FABP1 Antibodies), ultimately impacting obesity-driven hyperglycaemia.
This study indicates that PPAR alpha (show PPARA Antibodies) activation drives demethylation of the CpG islands of the Gadd45b promoter in the mouse liver and that epigenetic change at the Gadd45b promoter is critical for Gadd45b induction.
Data suggest that the increased expression of Gadd45beta induced by repeated administration of L-DOPA may be beneficial in patients with Parkinson's disease.
lower nucleus accumbens levels may affect Bdnf (show BDNF Antibodies) expression possibly leading to altered alcohol-drinking behavior
Gadd45b mediates the action of electroconvulsive shock-induced neural stem cell proliferation in the hippocampus.
Results suggest the possibility that differential Gadd45a (show GADD45A Antibodies), Gadd45b and Gadd45g (show GADD45G Antibodies) expression during development affects neurons, contributing cortical evolution and diversity
Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3 (show STAT3 Antibodies).
Modulation of the TGFbeta (show TGFB1 Antibodies)/NFkappaB/Gadd45b signaling pathway may provide a means to enhance the neuroprotective effect of Gadd45b in RGCs.
These results implicate Gadd45b as a learning-induced gene and a regulator of memory formation and are consistent with its potential role in active DNA demethylation in memory.
We propose a signaling cascade involving ARID1A (show ARID1A Antibodies), GADD45B and DUSP1 (show DUSP1 Antibodies) as mediators of the romidepsin effects in GCC (show GUCY2C Antibodies) cells.
present study provides evidence that variations in GADD45B rs2024144T, MAPK14 (show MAPK14 Antibodies) rs3804451A and GADD45A (show GADD45A Antibodies) rs581000C may predict platinum-based chemotherapy toxicity outcomes in patients with advanced non-small cell lung cancer
These findings demonstrate that 19p13.3-GADD45B rs7354 variant and interaction between 19p13.3-GADD45B rs3783501 and 19q13.3-CD3EAP (show CD3EAP Antibodies) rs967591 may play a role in association with smoke-exposed lung cancer among Chinese.
We used a new approach to search for human genes repressed by small nucleic acids (microRNAs) expressed by a gammaherpesvirus (KSHV), which identified a gene called GADD45B as a target of microRNAs. Repression of GADD45B, which is expressed in response to DNA damage, benefited survival of infected cells in response to a DNA damage response. This information could be used to design new treatments for herpesvirus infections
Gadd45beta could be a suitable biomarker of cardiomyocytes apoptosis in newborns experiencing hypoxia in the first day of life, as its highest tissue immunoexpression around at the first six hours after birth.
Nrf2 (show GABPA Antibodies)-Gadd45b signaling axis exhibited a protective role in antimony trioxide-induced cell apoptosis.
our data demonstrate that C/EBPbeta (show CEBPB Antibodies) plays a central role in controlling Gadd45beta gene expression in articular chondrocytes
The gadd45b gene has both tumor suppressor and tumor promoter functions, dependent on the tissue/cell type and transforming event. (Review)
Gadd45B protects the liver through two entirely different processes: binding MKK7 (show MAP2K7 Antibodies) to block damaging signal transduction or binding CAR to coactivate anabolic transcription. (Review)
as such may play an unappreciated role in tumorigenesis. The exact mechanism of GADD45B inactivation and overexpression requires further investigation. GADD45B could be a potential therapeutic target for CRC (show CALR Antibodies) treatment in future
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.
, growth arrest and DNA damage 45 beta
, Myeloid differentiation primary response protein MyD118
, growth arrest and DNA damage-inducible protein GADD45 beta
, growth arrest and DNA-damage-inducible protein GADD45 beta
, myeloid differentiation primary response gene 118
, myeloid differentiation primary response protein MyD118
, negative growth regulatory protein MyD118
, myeloid differentiation primary response
, growth arrest and DNA-damage-inducible 45 beta