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These data reveal a MAPK pathway-independent switch in response to cAMP signaling during melanoma progression.Implications: The prosurvival mechanism involving the cAMP-EPAC-RAP1 signaling pathway suggest the potential for new targeted therapies in melanoma.
Rap1 telomeric and non-telomeric functions and potential implications in diabetic cardiomyopathy have been discussed. (Review)
the cytoplasmic RAP1 (show RABGEF1 Proteins)-NF-kappaB (show NFKB1 Proteins)-BCL2 (show BCL2 Proteins) axis represents a key pathway to cisplatin resistance in non-small cell lung cancer cells.
Rap1GAP (show RAP1GAP Proteins) functions as a novel suppressor of epithelial mesenchymal transformation and tumor metastasis in gastric cancer, and loss of Rap1GAP (show RAP1GAP Proteins) predicts poor prognosis.
The formation of the Rap1 (show RABGEF1 Proteins)-TRF2 (show TERF2 Proteins) complex restored DNA unwinding.
Rap1 may induce hepatic ischemia reperfusion injury (IRI) through promoting neutrophils inflammatory response. Rap1 may be the potential therapeutic target of attenuating hepatic IRI.
The Rap1 (show RABGEF1 Proteins)-RIAM (show APBB1IP Proteins)-talin axis of integrin activation and blood cell function
Rap1 (show RABGEF1 Proteins) activation was dependent on PKA and required Src (show SRC Proteins) family kinases and the Rap1 (show RABGEF1 Proteins) exchanger C3G (show RAPGEF1 Proteins).
RAP1 (show RABGEF1 Proteins) promotes colorectal cell migration through the regulation of Vimentin (show VIM Proteins) and RAP1 (show RABGEF1 Proteins) may act as a potential target for the diagnosis and therapy of CRC (show CALR Proteins).
Data show that isoform beta2 of the heregulin (HRGbeta2) localizes at telomeres with the telomere-associated proteins TRF2 and RAP1.
HS1 as an important regulator of proper Rac1 and Rap1 activation and neutrophil extravasation.
Rap1 activation was dependent on PKA and required Src (show SRC Proteins) family kinases and the Rap1 exchanger C3G (show RAPGEF1 Proteins).
Collectively the observations uncover a requirement for Rap1 in maintenance of lens epithelial phenotype and morphogenesis.
our results indicate that Rasa3 catalytic activity controls Rap1 activation and integrin signaling during megakaryocyte differentiation in mouse.
RASA3, inhibits platelet activation and provides a link between P2Y12 and activation of the RAP1 signaling pathway.
we summarize recent developments in understanding the small G protein (show RAC2 Proteins) RAP1 and its effector RASIP1 (show RASIP1 Proteins) as critical mediators of endothelial junction stabilization.
Molecular investigation revealed that deletion of RAP1 reduced upregulation of inflammatory cytokine (IL1A (show IL1A Proteins)), finely regulated the expression of angiogenic factor (VEGF (show VEGFA Proteins)), and antiangiogenic factor (PEDF (show SERPINF1 Proteins)), following injury for better corneal recovery.
Cdk5-mediated serine-phosphorylation of C3G may control Rap1 stability and activity
Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22.
, TERF2-interacting telomeric protein 1
, TRF2-interacting telomeric RAP1 protein
, TRF2-interacting telomeric protein 1
, dopamine receptor interacting protein 5
, dopamine receptor-interacting protein 5
, repressor/activator protein 1 homolog
, telomeric repeat-binding factor 2-interacting protein 1
, TRF2-interacting telomeric protein Rap1