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anti-Mouse (Murine) HAP1 Antibodies:
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Human Monoclonal HAP1 Primary Antibody for ICC, FACS - ABIN259097
Chan, Nasir, Gutekunst, Coleman, Maclean, Maas, Metzler, Gertsenstein, Ross, Nagy, Hayden: Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. in Human molecular genetics 2002
Show all 7 Pubmed References
Mouse (Murine) Monoclonal HAP1 Primary Antibody for IF, WB - ABIN968461
Gutekunst, Li, Yi, Ferrante, Li, Hersch: The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
Show all 5 Pubmed References
Human Polyclonal HAP1 Primary Antibody for IHC, ELISA - ABIN1002402
Borrell-Pagès, Zala, Humbert, Saudou: Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies. in Cellular and molecular life sciences : CMLS 2006
Show all 4 Pubmed References
Monoclonal HAP1 Primary Antibody for IHC (fro), IP - ABIN534035
Gutekunst, Torre, Sheng, Yi, Coleman, Riedel, Bujo: Stigmoid bodies contain type I receptor proteins SorLA/LR11 and sortilin: new perspectives on their function. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003
Show all 2 Pubmed References
Human Polyclonal HAP1 Primary Antibody for ELISA, WB - ABIN188689
Takeshita, Fujinaga, Zhao, Yanai, Shinoda: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. in Human molecular genetics 2006
AOM (show COL2A1 Antibodies), a colorectal cancer carcinogen, generates damage to the mitochondrial genome, and the BER enzyme APE1 (show APEX1 Antibodies) is required to maintain its integrity.
This study also validated the interaction between HAP1 and Sec23A (show SEC23A Antibodies) using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins
findings provide evidence that endogenous APE1 (show APEX1 Antibodies) protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury
HAP1 co-localizes with synapsin I (show SYN1 Antibodies) in cortical neurons as discrete puncta
Suppression of Ape1/Ref-1 (show APEX1 Antibodies) redox function leads to an increased cell surface retention of IL-12 (show IL12A Antibodies) and enhances Th1 (show HAND1 Antibodies) responses.
findings suggest that Hap1 is important for insulin (show INS Antibodies) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (show CACNA1C Antibodies), providing new insight into the mechanisms that regulate insulin (show INS Antibodies) release from pancreatic beta-cells.
Is closely associated with upregulation of the Ref1 (show THOC4 Antibodies)/Nrf2 (show NFE2L2 Antibodies) signalling pathway.
Results show the stimulatory effect of PARP-1 (show PARP1 Antibodies) on APE1 (show APEX1 Antibodies)-dependent base excision repair (BER). PARP-1 (show PARP1 Antibodies) and APE1 (show APEX1 Antibodies) appear to have a functional interaction in BER since PARP-1 (show PARP1 Antibodies) can stimulate the strand incision activity of APE1 (show APEX1 Antibodies).
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (show BCR Antibodies) on microtubules to regulate neuronal differentiation.
HAP1 (show APEX1 Antibodies) is expressed in endocrine cells of the human gut (show GUSB Antibodies).
data fully support that HAP1 (show APEX1 Antibodies) is a GKAP (show DLGAP1 Antibodies), anchoring specifically to the cGMP-dependent protein kinase (show CDK7 Antibodies) isoform Ibeta, and provide further evidence that also PKG (show PRKG1 Antibodies) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (show APEX1 Antibodies) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (show APEX1 Antibodies) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (show APEX1 Antibodies) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (show APEX1 Antibodies) co-localizes and associates with APP (show APP Antibodies) in physiological conditions of mouse and human brain.
WT HTT (show HTT Antibodies) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (show PCM1 Antibodies)).
HAP1 (show APEX1 Antibodies)/stigmoid body interacts with the normal ataxin-3 (show ATXN3 Antibodies) through Josephin (show ATXN3 Antibodies) domain
sortilin (show SORT1 Antibodies) stabilizes the proBDNF.HAP1 complex
ADORA2A (show ADORA2A Antibodies), but not HAP1 (show APEX1 Antibodies) or OGG1 (show OGG1 Antibodies), may have a role in age at onset in Huntington's disease
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
AP endonuclease 1
, APEX nuclease
, DNA-(apurinic or apyrimidinic site) lyase
, apurinic-apyrimidinic endonuclease 1
, redox factor-1
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)