Browse our anti-HAP1 (HAP1) Antibodies

Human Huntingtin Associated Protein 1 (HAP1) interaction partners

1. HAP1 (show APEX1 Antibodies) is expressed in endocrine cells of the human gut (show GUSB Antibodies).

2. data fully support that HAP1 (show APEX1 Antibodies) is a GKAP (show DLGAP1 Antibodies), anchoring specifically to the cGMP-dependent protein kinase (show CDK7 Antibodies) isoform Ibeta, and provide further evidence that also PKG (show PRKG1 Antibodies) spatiotemporal signaling is largely controlled by anchoring proteins

3. HAP1 (show APEX1 Antibodies) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity

4. Overexpression of HAP1 (show APEX1 Antibodies) reduced in vitro cell growth in breast cancer cell lines.

5. The results of this study found no association was found between the HAP1 (show APEX1 Antibodies) T441M polymorphism and the age at onset of Huntington's disease .

6. The results of this study suggested that HAP1 (show APEX1 Antibodies) co-localizes and associates with APP (show APP Antibodies) in physiological conditions of mouse and human brain.

7. WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1).

8. HAP1 (show APEX1 Antibodies)/stigmoid body interacts with the normal ataxin-3 (show ATXN3 Antibodies) through Josephin (show ATXN3 Antibodies) domain

9. sortilin (show SORT1 Antibodies) stabilizes the proBDNF.HAP1 complex

10. ADORA2A (show ADORA2A Antibodies), but not HAP1 (show APEX1 Antibodies) or OGG1 (show OGG1 Antibodies), may have a role in age at onset in Huntington's disease

Mouse (Murine) Huntingtin Associated Protein 1 (HAP1) interaction partners

1. Depleting Huntingtin-associated protein 1 (Hap1) promoted the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A (show DYRK1A Antibodies))-DDB1 and CUL4 associated factor 7 (Dcaf7 (show DCAF7 Antibodies)) interaction and increased the DYRK1A (show DYRK1A Antibodies) protein level.

2. This study also validated the interaction between HAP1 and Sec23A (show SEC23A Antibodies) using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins

3. HAP1 co-localizes with synapsin I (show SYN1 Antibodies) in cortical neurons as discrete puncta

4. findings suggest that Hap1 is important for insulin (show INS Antibodies) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (show CACNA1C Antibodies), providing new insight into the mechanisms that regulate insulin (show INS Antibodies) release from pancreatic beta-cells.

5. Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.

6. Hap1 interacts with Bcr (show BCR Antibodies) on microtubules to regulate neuronal differentiation.

7. HAP1 regulates exocytosis by influencing the morphological docking of vesicles at the plasma membrane, the ability of vesicles to be released rapidly upon stimulation, and the early stages of fusion pore formation.

8. these studies identify htt (show HTT Antibodies) and HAP1 as regulators of autophagosome transport in neurons

9. In the absence of HAP1, postnatal hypothalamic neurons exhibited reduced receptor tropomyosin-related kinase B (TRKB (show NTRK2 Antibodies)) levels.

10. Hap1-Tsc1 (show TSC1 Antibodies) interaction regulates neuronal mTORC1 signaling and neuronal morphogenesis.