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our data indicate that miR (show MLXIP Proteins)-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting TUSC3 in glioblastoma.
This paper supports the previous clinical descriptions of the condition caused by TUSC3 mutations and describes the seventh family with mutations in this gene, thus contributing to the genetic spectrum of mutations. This is the first report of a family from the Arabian peninsula with this form of Intellectual disability .
SOX2 (show SOX2 Proteins) regulates the proliferation, migration and invasiveness of breast cancer cells through miR (show MLXIP Proteins)-181a-5p and miR (show MLXIP Proteins)-30e-5p which modulate TUSC3 protein levels
Decreased Tumor Suppressor Candidate 3 Predicts Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma
TUSC3 regulates proliferation and invasion of glioblastoma cells by inhibiting the activity of the Akt (show AKT1 Proteins) signaling pathway.
decreased immunological TUSC3 staining is a factor prognostic of poor survival in pancreatic cancer patients.
The TUSC3 gene is associated with mental retardation in the Qinba mountain area in China; the sixth exon of the TUSC3 gene may contribute to the risk of developing the disease.
Report frequencies of short tandem repeat markers linked to TUSC3 (MRT7) or NSUN2 (MRT5 (show NSUN2 Proteins)) genes used for homozygosity mapping of recessive intellectual disability.
TUSC3 loss alters the ER stress response and accelerates prostate cancer growth in vivo
Loss of TUSC3 alters the molecular response to endoplasmic reticulum stress.
This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene.
tumor suppressor candidate 3
, Putative prostate cancer tumor suppressor
, magnesium uptake/transporter TUSC3
, oligosaccharyltransferase 3 homolog A
, putative prostate cancer tumor suppressor