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Human Monoclonal CUX1 Primary Antibody for IF, IHC (p) - ABIN560539
Saito, Hanai, Takashima, Nakagawa, Okazaki, Inoue, Miyata, Hoshino, Akashi, Sasaki, Goto, Hayashi, Itoh: Neocortical layer formation of human developing brains and lissencephalies: consideration of layer-specific marker expression. in Cerebral cortex (New York, N.Y. : 1991) 2011
Show all 2 Pubmed References
Human Polyclonal CUX1 Primary Antibody for IHC, IHC (p) - ABIN4297097
Mestres, Chuang, Calegari, Conde, Sung: SARA regulates neuronal migration during neocortical development through L1 trafficking. in Development (Cambridge, England) 2016
Cow (Bovine) Polyclonal CUX1 Primary Antibody for WB - ABIN2778283
Truscott, Harada, Vadnais, Robert, Nepveu: p110 CUX1 cooperates with E2F transcription factors in the transcriptional activation of cell cycle-regulated genes. in Molecular and cellular biology 2008
Human Polyclonal CUX1 Primary Antibody for IF, IHC (p) - ABIN652075
Fragiadaki, Ikeda, Witherden, Mason, Abraham, Bou-Gharios: High doses of TGF-? potently suppress type I collagen via the transcription factor CUX1. in Molecular biology of the cell 2011
High CUX1 expression is associated with resistance of glioblastoma cells to temozolomide.
the findings demonstrated that mutated K-ras promotes cathepsin L expression and plays a pivotal role in EMT of human lung cancer. The regulatory effect of IR-induced cathepsin L on lung cancer invasion and migration was partially attributed to the Cathepsin L /CUX1-mediated EMT signaling pathway
Our data indicate that there exist frameshift mutations of CUX1 and SIRT1 genes as well as intratumoral heterogeneity of CUX1 frameshift mutation in high microsatellite instability cancers, which together might play a role in tumorigenesis of gastric cancer and colorectal cancer with high microsatellite instability
CUX1 is enriched at sites of DNA looping, as determined by Hi-C analysis, and these loops connect CUX1 to the promoters of regulated genes.
our results have uncovered the requirement for CUX1 expression in cancer cells with elevated reactive oxygen species levels
Therefore, we show for the first time that the nuclear localization of Cat L and its substrate Cux1can be positively regulated by Snail NLS and importin beta1, suggesting that Snail, Cat L and Cux1 all utilize importin beta1 for nuclear import.
a positive feedback loop between Snail-nuclear Cat L-CUX1 drives epithelial mesenchymal transition, is reprted.
Study found are higher CUTL1 expression level in non-small cell lung cancer (NSCLC) tissues and showed that CUTL1 induced epithelial-mesenchymal transition in NSCLC.
Results show that Cux1 is expressed in cerebellar granule cell precursors and downregulated as they terminally differentiate; coexpression analysis in human medulloblastomas suggests another function related to DNA integrity and stability
High CUX1 expression is associated with metastasis in pancreatic neuroendocrine neoplasms.
Authors identified CUX1 as an important modulator of the TAMs phenotype and function by modulating NF-kappaB-dependent cytokines.
This is a novel gene implicated in atrial fibrillation
CASP is specifically cleaved by granzymeB.
Suggest that CUTL1 may regulate the proliferation of malignant melanoma by modulating the expression of cell cycle-related proteins.
CUX1 expression is associated with tumour progression and tumor burden. [Review]
Loss of CUX1 is associated with myeloid neoplasms.
Cux1 is a tumor suppressor and inactivating CUX1 mutations promote tumorigenesis.
Our results provide the first evidence that polymorphisms of the CUX1 gene may be associated with response to antidepressant treatment in Japanese patients with MDD.
p110 CUX1 can mediate transcriptional repression or activation of specific genes when bound at variable distances from the transcription start site.
Authors found that both chromosomal inversions target the cut-like homeobox 1 (CUX1) gene on chromosomal band 7q22.1 in a way which is functionally equivalent to the more frequently observed del(7q) cases.
To determine the role for CUX1 in hematopoiesis, this study generated 2 short hairpin RNA-based mouse models with approximately 54% (Cux1(mid)) or approximately 12% (Cux1(low)) residual CUX1 protein. Cux1(mid) mice develop myelodysplastic syndrome (MDS) with anemia and trilineage dysplasia, whereas CUX1(low) mice developed MDS/myeloproliferative neoplasms and anemia.
reduction of VAV2 in absence of CUX1 was associated with a significant decrease of RAC1 activity in response to epithelial wounding. Our results identify a novel pathway by which CUX1 regulates normal intestinal epithelial cell restitution
Cux1 expression in polycystic kidney disease is not directly involved in cystogenesis but promotes cell proliferation required for expansion of existing cysts, primarily by repression of p27.
Cux1 is essential for the developmental modulation of intrinsic excitability and the switch to a Kv1-dependent firing mode necessary for interhemispheric innervation.
Findings reinforce the link between oxidative DNA damage and cellular senescence and suggest that the role of CUX1 as an accessory factor in DNA repair will be critical in physiological situations that generate higher levels of reactive oxygen species.
Results suggest that by their differential effects on basal and apical dendrites, Cux1 and Cux2 can promote the integration of layer II-III neurons in the intracortical networks in highly specific ways
Results show that Cux1 is expressed in cerebellar granule cell precursors and downregulated as they terminally differentiate; suggests some limitations of established medulloblastoma cell lines and mouse models
CUX1 functions in base excision repair as an ancillary factor for the 8-oxoG-DNA glycosylase, OGG1.
overexpression of active CUTL1 significantly resulted in increased cancer tissue response to chemotherapy and therefore inhibited growth, whereas knockdown of CUTL1 conferred resistance to chemotherapy.
CUX1, a direct target of microRNA122, is a common central mediator of two effects of microRNA122 disregulation; alpha-fetoprotein upregulation and an aggressive phenotype in hepatocellular carcinoma.
Increased Cux1 expression associated with apoptosis is a common feature of late stage cyst progression in both the cpk and Pkd1(CD) mouse models of polycystic kidney disease.
Unlike the somatic form of CUX1, which has a role in cell proliferation, the testis-specific form of CUX1 is not involved in cell division and appears to play a role in signaling between Sertoli cells and spermatids.
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling.
Loss of Cux1 transcriptional activity during dextran sulfate sodium (DSS)-induced colitis leads to a severe increase of colonic inflammation.
the hyperphosphorylation of CUX1 by cyclin B/CDK1 inhibits its DNA binding activity in mitosis and interferes with its nuclear localization following cell division and formation of the nuclear membrane
CUX1 interacts in vivo with multiple DNA-binding sites in the 5'-UTR and promoter of the PLZF gene in colorectal cancer cells
Cux1 and Cux2 play critical roles in dendritogenesis via subclass-specific mechanisms of synapse regulation that contribute to the establishment of cognitive circuits.
deregulation of expression results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia
Variations in Cux/CDP binding and matrix attachment region activity contribute to localized control of accessibility and therefore nonrandom gene use during V(D)J recombination.
expression of Cux-1 is sufficient to induce the early events of mesangioproliferative glomerulonephritis
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.
CCAAT displacement protein
, cut homolog
, golgi integral membrane protein 6
, homeobox protein cux-1
, protein CASP
, putative protein product of Nbla10317
, cut-like homeobox 1
, (clone C8) CASP
, cut-like 1, CCAAT displacement protein
, homeobox protein cut-like 1-like
, Cux/CDP homeoprotein
, cut-like 1
, homeobox protein cut-like 1
, cut-like homeobox 1b