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anti-Human CX3CR1 Antibodies:
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Human Polyclonal CX3CR1 Primary Antibody for CyTOF, FACS - ABIN4900502
Fan, Xiong, Zhang, Yan, Jian, Xu, Zhao: MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. in Journal of the American Heart Association 2016
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Mouse (Murine) Polyclonal CX3CR1 Primary Antibody for FACS - ABIN4897825
Wattananit, Tornero, Graubardt, Memanishvili, Monni, Tatarishvili, Miskinyte, Ge, Ahlenius, Lindvall, Schwartz, Kokaia: Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Show all 3 Pubmed References
Mouse (Murine) Polyclonal CX3CR1 Primary Antibody for FACS - ABIN4897824
Andriessen, Wilson, Mawambo, Dejda, Miloudi, Sennlaub, Sapieha: Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization. in EMBO molecular medicine 2016
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Human Polyclonal CX3CR1 Primary Antibody for ELISA, FACS - ABIN4301023
Aoyama, Inokuchi, Brenner, Seki: CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. in Hepatology (Baltimore, Md.) 2010
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Human Polyclonal CX3CR1 Primary Antibody for FACS, IHC - ABIN110594
Held-Feindt, Hattermann, Mueerkoester, Wedderkopp, Knerlich-Lukoschus, Ungefroren, Mehdorn, Mentlein: CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs). in Experimental cell research 2010
Human Polyclonal CX3CR1 Primary Antibody for WB - ABIN411456
Kim, Rooper, Xie, Kajdacsy-Balla, Barbolina: Fractalkine receptor CX(3)CR1 is expressed in epithelial ovarian carcinoma cells and required for motility and adhesion to peritoneal mesothelial cells. in Molecular cancer research : MCR 2012
Human Monoclonal CX3CR1 Primary Antibody for ELISA, WB - ABIN560540
Nevo, Sagi-Assif, Meshel, Ben-Baruch, Jöhrer, Greil, Trejo, Kharenko, Feinmesser, Yron, Witz: The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells. in Cancer letters 2008
Human Polyclonal CX3CR1 Primary Antibody for FACS, WB - ABIN2473127
Imai, Hieshima, Haskell, Baba, Nagira, Nishimura, Kakizaki, Takagi, Nomiyama, Schall, Yoshie: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. in Cell 1997
Show all 2 Pubmed References
Human Monoclonal CX3CR1 Primary Antibody for FACS - ABIN4896933
Falk, Singh, Faber, Nissen, Hviid, Sørensen: CX3CL1/CX3CR1 and CCL2/CCR2 chemokine/chemokine receptor complex in patients with AMD. in PLoS ONE 2014
Our findings demonstrate that motility, invasion, and contact-independent growth of PDAC cells all increase following CX3CL1 (show CX3CL1 Antibodies) exposure, and that antagonism of CX3CR1 by the inhibitor JMS (show ATRX Antibodies)-17-2 reduces each of these phenotypes and correlates with a downregulation of AKT (show AKT1 Antibodies) phosphorylation.
in Crohn's disease patients, a missense mutation in the gene encoding CX3CR1 was identified and found to be associated with impaired antifungal responses
CX3CL1 (show CX3CL1 Antibodies)/CX3CR1 axis plays a key role in the development of ischemia-induced oligodendrocyte injury via p38MAPK (show MAPK14 Antibodies) signaling pathway.
Soluble FKN that was efficiently shed from the surface of LPS (show IRF6 Antibodies)-activated ECs in response to binding of CD16 (show CD16 Antibodies)(+) monocytes to ECs, diminished monocyte adhesion in down-regulating CX3CR1 expression on the surface of CD16 (show CD16 Antibodies)(+) monocytes resulting in decreased TNF (show TNF Antibodies)-secretion.
CX3CR1 genetic variants were not associated with risk of atherosclerotic coronary heart disease and glucometabolic traits in European ancestry cohort. In a South Asian cohort, identified CX3CR1 SNP associated with myocardial infarction and type II diabetes mellitus.
FKN and CX3CR1 expression was significantly increased in pancreatic ductal adenocarcinoma (PDAC) tissues, especially in the metastatic samples, and was highly-correlated with severity of PDAC. Ectopic expression of FKN promoted the proliferation and migration of PDAC, while knockdown of CX3CR1 reversed the function of FKN.
CX3CL1 (show CX3CL1 Antibodies) is upregulated in both human and murine tumors following VEGF (show VEGFA Antibodies) signaling blockade, resulting in recruitment of CX3CR1+Ly6Clo monocytes into the tumor
The fractalkine (show CX3CL1 Antibodies) functions on the activation of the AKT (show AKT1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)/p65 (show GORASP1 Antibodies) signalling cascade and regulation of the antiapoptosis process in pancreatic cancer cells.
High expression of CX3CR1 correlates with significantly shorter survival, specifically in post-menopausal patients with advanced and terminal stages of the disease. Taken together, this support a key regulatory role for the fractalkine (show CX3CL1 Antibodies) axis in advanced and relapsed peritoneal metastasis in epithelial ovarian carcinoma.
V249I genotype of the fractalkine receptor showed a protector role in patients with type 2 diabetes. The T280M genotype is associated with increased carotid intima-media thickness in Mexican individuals with or without type 2 diabetes
Although CCR2 (show CCR2 Antibodies) and CX3CR1 may synergistically impact inflammatory phenotypes, their joint deficiency did not influence the metabolic effects of a 45% high-fat diet-induced obesity in these model conditions.
that CX3CL1 (show CX3CL1 Antibodies)-CX3CR1 signaling is a molecular mechanism capable of modulating microglial-mediated degeneration
Increased fractalkine (show CX3CL1 Antibodies) and its receptor CX3CR1 may cause a cross-talk between activated glial cells and neurons, playing an important role in the development of neuroinflammation in fructose-fed mice.
CX3CR1 deficiency accelerates the development of vascular pathology in diabetic retinopathy.
CX3CR1(-/-) mice did not become anhedonic in the "two hit" chronic stress paradigm, confirming resistance of these animals to chronic stress-induced mood alterations. However, there was no difference in stress hormone levels, open field performance and hypothalamic microglia distribution between the genotypes. Energy expenditure was increased in CX3CR1(-/-) mice, which may be related to their active coping behavior.
Inflammatory Osteoclasts Prime TNFalpha (show TNF Antibodies)-Producing CD4 (show CD4 Antibodies)(+) T Cells and Express CX3 CR1 (show TDGF1 Antibodies)
our study demonstrates that macrophages expressing a functional CX3CR1 receptor have an important and non-redundant role in controlling the abnormal intestinal inflammation that may lead to tissue damage.
These results highlight the importance of fractalkine (show CX3CL1 Antibodies)-CX3CR1 interaction in recruitment of macrophages into the brown adipose tissue of obese mice.
Results indicate that deletion of CX3CR1 from microglia under resting conditions modifies brain areas with elevated cellular turnover independent of CX3CL1 (show CX3CL1 Antibodies).
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
, CX3C chemokine receptor 1
, G protein-coupled receptor 13
, G-protein coupled receptor 13
, beta chemokine receptor-like 1
, chemokine (C-C) receptor-like 1
, chemokine (C-X3-C) receptor 1
, fractalkine receptor
, CX3C chemokine receptor 1-like
, Fractalkine receptor
, chemokine receptor 1
, chemokine (C-X3-C motif) receptor 1