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anti-Human Fibronectin Antibodies:
anti-Mouse (Murine) Fibronectin Antibodies:
anti-Rat (Rattus) Fibronectin Antibodies:
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Chicken Monoclonal Fibronectin Primary Antibody for ICC, IHC (fro) - ABIN3043242
Zhang, Chen, Qi, Wang, Xiao, Zhu: Inhibition of calcium-calmodulin-dependent kinase II suppresses cardiac fibroblast proliferation and extracellular matrix secretion. in Journal of cardiovascular pharmacology 2010
Show all 15 Pubmed References
Human Monoclonal Fibronectin Primary Antibody for FACS, ELISA - ABIN969520
Ryschich, Khamidjanov, Kerkadze, Büchler, Zöller, Schmidt: Promotion of tumor cell migration by extracellular matrix proteins in human pancreatic cancer. in Pancreas 2009
Show all 2 Pubmed References
Human Monoclonal Fibronectin Primary Antibody for FACS, IHC - ABIN969149
Huang, Zhang, Kim, Ge, Annis, Mosher, Greenspan: Fibronectin binds and enhances the activity of bone morphogenetic protein 1. in The Journal of biological chemistry 2009
Show all 2 Pubmed References
Human Monoclonal Fibronectin Primary Antibody for FACS - ABIN4898545
Purushothaman, Bandari, Liu, Mobley, Brown, Sanderson: Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. in The Journal of biological chemistry 2016
Injection of alpha5beta1 protein rescued the Fibronectin layer and then the myocardial precursor migration in snai1b knockdown embryos.
Fibronectin, a main component of the extracellular matrix, is induced and deposited after cardiac damage
Fibronectin deficiency resulted in a dramatic reduction of mesoderm accompanied by endodermal expansion in zebrafish embryos.
Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
reduction of fn1 function enables rescue of cardiac fusion in hand2 (show HAND2 Antibodies) mutants
Fibronectin regulates epithelial organization during myocardial migration in zebrafish.
miR1271 inhibited glioma cell growth by targeting FN1, and a low level of miR1271 in glioma tumor tissues was associated with lower survival rates in patients with glioma.
There is a significant association between a positive fetal fibronectin result and underlying inflammatory pathology of the placenta, even more so than the recognized relationship with short cervical length.
The article focuses on summarizing the many binding partners for fibronectin such as extracellular matrix proteins, growth factors, and synthetic binding partners with a particular interest in binding partners whose adhesiveness is impacted by the molecular conformation of the fibronectin fibers. (Review)
FN1 fibrils regulate TGFB1 (show TGFB1 Antibodies)-induced epithelial-mesenchymal transition.
Breast cancer cells alter the dynamics of stromal fibronectin-collagen interactions.
This study suggested that high a1-antitrypsin (AAT (show SERPINA1A Antibodies))expression might be a negative prognostic marker for lung adenocarcinoma. AAT (show SERPINA1A Antibodies) promoted lung adenocarcinoma metastasis, whose functional target may be fibronectin . Our findings provide new insight into the mechanisms of lung adenocarcinoma metastasis
Data show the expression of ED-B fibronectin was much higher in mesenchymal than prostate cancer cells even after the epithelial to mesenchymal transition. Epithelial to mesenchymal transition is a key step for tumor progression contributing to the metastatic spread. Therefore, circulating cancer cells could seed into the metastatic niche taking advantage from the ED-B fibronectin that secrete their own.
Thrombomodulin (TM (show THBD Antibodies)) promotes angiogenesis by enhancing cell adhesion, migration, and FAK (show PTK2 Antibodies) activation through interaction with fibronectin.
thyroid nodule stiffness is correlated with fibrosis and expression of Gal-3 (show LGALS3 Antibodies) and FN-1
EGF (show EGF Antibodies) and TNFalpha (show TNF Antibodies) cooperatively promoted the motility of HCC (show FAM126A Antibodies) cells mainly through NF-kappaB (show NFKB1 Antibodies)/p65 (show GORASP1 Antibodies) mediated synergistic induction of FN in vitro. These findings highlight the crosstalk between EGF (show EGF Antibodies) and TNFalpha (show TNF Antibodies) in promoting HCC (show FAM126A Antibodies), and provide potential targets for HCC (show FAM126A Antibodies) prevention and treatment.
Factor XIII (show UGDH Antibodies)-A and TG2 (show TGM2 Antibodies) regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
we disclosed the role of chemotaxis and apoptosis in the fibrotic microenvironment-enhanced seeding of tumor cells and identified the fibroblast-derived FN1 and SPP1 (show SPP1 Antibodies) as the central mediators in these processes
PD increased CKIP-1 and Nrf2 (show NFE2L2 Antibodies) levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 (show ICAM1 Antibodies)
Histone methyltransferase Suv39h1 (show SUV39H1 Antibodies) attenuates high glucose-induced fibronectin and p21(WAF1 (show CDKN1A Antibodies)) in mesangial cells
fibronectin has a critical role in tissue morphogenesis and the development of tissue heterogeneities
The aged stem cell niche in skeletal muscle contains reduced levels of FN, leading to detrimental consequences for the function and maintenance of muscle stem cells (MuSCs). FN is a preferred adhesion substrate for MuSCs and integrin-mediated signaling via focal adhesion kinase and the p38 MAPK (show MAPK14 Antibodies) pathway is strongly de-regulated in MuSCs from aged mice because of insufficient attachment to the niche.
analysis of novel functions for two fibronectin isoforms and the mediating receptors in osteoblast differentiation
scleraxis (show SCX Antibodies) was required for TGFbeta (show TGFB1 Antibodies)-induced fibronectin expression: TGFbeta (show TGFB1 Antibodies) lost its ability to induce fibronectin expression following scleraxis (show SCX Antibodies) knockdown.
The results very comprehensively demonstrate distinct signaling pathways that regulate microfilament organization, lamellipodial structures, spreading, and movement of cells plated on galectin-3 (show LGALS3 Antibodies) as opposed to fibronectin.
Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine.
plasma FN assembly into bone matrix in vitro requires FXIIIA transglutaminase activity making pFN assembly an active, osteoblast-mediated process.
Fetal and adult human skin fibroblasts retain their differential proliferative response to TGF-beta (show TGFB1 Antibodies) when cultured in the presence of fibronectin and unpolymerized or polymerized collagen.
Putative function of fibronectin and its receptor (integrin alpha(5 (show ITGA5 Antibodies))beta(1)) in male and female gametes during bovine fertilization in vitro.
These results highlight a crucial role for caveolin-1 (show CAV1 Antibodies) in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins.
P. multocida-Fn interaction may play a role in the bacterium adherence to host cells, and this may be mediated by bacterial surface proteins with preferential affinity for the Hep-1 binding domain of Fn
The expression of extracellular matrix molecules fibronectin and osteopontin (show SPP1 Antibodies) in vitreous and retina samples in autoimmune uveitis was investigated.
The expression of the differentiation and stemness genes, FN1 and SOX9 (show SOX9 Antibodies), is accompanied by cell proliferation.
The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process.
The relationship between hyaluronan synthesis and levels of versican (show Vcan Antibodies), fibronectin and several other extracellular matrix components in trabecular meshwork cells from the anterior segment of the eye was investigated.
fibronectin has a cryptic binding site for tenascin (show TNC Antibodies)
Transplantation experiments demonstrate a tissue-autonomous role for DS epimerase (show DSE Antibodies)-1 in cranial neural crest (NC) cell migration in vivo Cranial NC explant and single-cell cultures indicate a requirement of DS epimerase (show DSE Antibodies)-1 in cell adhesion, spreading and extension of polarized cell processes on fibronectin.
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
, gene C
, cold-insoluble globulin
, migration-stimulating factor
, cumulus cell-specific fibronectin 1 transcript
, embryo-specific fibronectin 1 transcript
, fibronectin ED-A- region
, fibronectin variable region