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Pharmacologic and gene knock-out results suggest that Pde4b plays a critical role in coordinating alcohol-induced, peripheral endotoxemia mediated neuro-inflammation and could serve as a significant therapeutic target.
These results demonstrate that the alcohol- induced increase in hepatic Pde4 (show PDE4A Proteins), specifically Pde4b expression, and compromised cAMP signalling predispose the liver to impaired fatty acid oxidation and the development of steatosis.
PDE4B phosphorylated by AMPK (show PRKAA1 Proteins) at Ser304 is important for activation.
Lymphomas developing in a Pde4b-null background display significantly lower microvessel density in association with lower VEGF (show VEGFA Proteins) levels and PI3K/AKT (show AKT1 Proteins) activity.
Genetic variations in DISC1 influence formation of biochemical complex with PDE4 and GSK-3 and strengthen the possibility of synergistic interactions between these proteins.
PDE4B-deficient mice display impaired reversal learning in the Morris water maze compared to wild-type littermates.
Results identify PDE4B in the CaV1.2 (show CACNA1C Proteins) complex as a critical regulator of ICa during beta-AR stimulation and suggest that distinct PDE4 (show PDE4A Proteins) subtypes are important for normal regulation of calcium-induced calcium release in cardiomyocytes.
Findings demonstrate that PDE4D (show PDE4D Proteins) and PDE4B have specialized functions in mouse embryonic fibroblasts with PDE4B controlling cAMP in a discrete subdomain near the plasma membrane.
induction is esssential for LPS (show TLR4 Proteins)-activated tnf-alpha (show TNF Proteins) responses
PDE4B mediates the antipsychotic effects of rolipram in conditioned avoidance responding; the PDE4B-regulated cyclic adenosine monophosphate signaling pathway may play a role in the pathophysiology and pharmacotherapy of psychosis
Data suggest that maternal glycemic response during pregnancy is associated with lower DNA methylation (show HELLS Proteins) of 4 CpG sites within PDE4B gene in placenta (collected after term birth); 3 additional CpG sites are differentially methylated relative to maternal glucose response within TNFRSF1B (show TNFRSF1B Proteins), LDLR (show LDLR Proteins), and BLM (show BLM Proteins) genes. (TNFRSF1B (show TNFRSF1B Proteins) = TNF (show TNF Proteins) receptor superfamily member-1B; LDLR (show LDLR Proteins) = low density lipoprotein receptor (show LDLR Proteins); BLM (show BLM Proteins) = Bloom syndrome protein (show BLM Proteins))
Smurf2 (show SMURF2 Proteins), an E3 ubiquitin ligase (show MUL1 Proteins), interacts with PDE4B and attenuates liver fibrosis through miR (show MLXIP Proteins)-132 mediated CTGF (show CTGF Proteins) inhibition.
HTT (show HTT Proteins) forms a ternary protein complex with the scaffolding protein DISC1 (show DISC1 Proteins) and cAMP-degrading phosphodiesterase 4 (PDE4 (show PDE4A Proteins)) to regulate PDE4 (show PDE4A Proteins) activity.
Low PDE4B expression is associated with sepsis.
PDE4B gene may be involved in the testicular abnormalities of men with DS and cryptorchidism.
This meta-analysis suggests that PDE4B SNPs are genetically associated with susceptibility to schizophrenia.
Our results suggest that PDE4B does not play an important role during the chemotactic response of human neutrophils
Our results support previously reported association of PDE4B variations with schizophrenia in other populations.
analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 (show GORASP1 Proteins)
ototopical post-inoculation administration of a PDE4 (show PDE4A Proteins) inhibitor suppresses inflammation in this animal model, thus demonstrating the therapeutic potential of targeting PDE4 (show PDE4A Proteins)
QTL-CI for IMF (show MDFI Proteins) was reconfirmed with high significance, and its position was narrowed down to an interval of 4 cM (the region defined by markers PDE4B and SW1881)
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog)
, phosphodiesterase 4B, cAMP-specific
, phosphodiesterase 4B
, 3',5'-cyclic AMP phosphodiesterase
, Phosphodiesterase 4B cAMP-specific (dunce
, Phosphodiesterase 4B, cAMP-specific (dunce
, cAMP-specific 3',5'-cyclic phosphodiesterase 4B
, cAMP-specific phosphodiesterase-4 B isoform
, dunce-like phosphodiesterase E4
, phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
, phosphodiesterase 4B, cAMP specific