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Human Polyclonal TSPO Primary Antibody for ICC, IF - ABIN188570
Fafalios, Akhavan, Parwani, Bies, McHugh, Pflug: Translocator protein blockade reduces prostate tumor growth. in Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Show all 8 Pubmed References
Human Polyclonal TSPO Primary Antibody for IHC, WB - ABIN222898
Ji, Maeda, Sawada, Ono, Okauchi, Inaji, Zhang, Suzuki, Ando, Staufenbiel, Trojanowski, Lee, Higuchi, Suhara: Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Human Polyclonal TSPO Primary Antibody for ELISA, WB - ABIN547741
Papadopoulos, Baraldi, Guilarte, Knudsen, Lacapère, Lindemann, Norenberg, Nutt, Weizman, Zhang, Gavish: Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. in Trends in pharmacological sciences 2006
Human Polyclonal TSPO Primary Antibody for ELISA, FACS - ABIN570960
Morgan, Cheepala, Wang, Neale, Adachi, Nachagari, Leggas, Zhao, Boyd, Venkataramanan, Schuetz: Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice. in The Journal of biological chemistry 2012
Mouse (Murine) Polyclonal TSPO Primary Antibody for ELISA, WB - ABIN4343998
Weisinger, Kelly-Hershkovitz, Veenman, Spanier, Leschiner, Gavish: Peripheral benzodiazepine receptor antisense knockout increases tumorigenicity of MA-10 Leydig cells in vivo and in vitro. in Biochemistry 2004
Human Polyclonal TSPO Primary Antibody for IHC, WB - ABIN4343997
Foss, Liu, Mease, Wang, Pasricha, Pomper: Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with (125)I-Iodo-DPA-713 SPECT/CT. in Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2017
Our data indicate that the LPS-induced increase in Tspo expression is mediated, at least in part, at the transcriptional level and is accompanied by an enhanced recruitment of Pu.1, cJun, cFos, Sp1, Sp3, and Sp4 factors to the distal and proximal regulatory sequences on the Tspo promoter.
PET imaging of (11)C-PK11195, a marker of the 18-kDa translocator protein (TSPO), revealed a transient increase at day 4 of hypoxia
Fluorescence microscopy revealed punctate TSPO immunostaining in vascular endothelial cells throughout the brain. In the olfactory nerve layers and glomeruli of the olfactory bulb, choroid plexus and ependymal layers, the study confirmed constitutive TSPO expression levels similar to peripheral organs, while some low TSPO expression is present in regions of known neurogenesis, as well as cerebellar Purkinje cells.
induced TSPO expression marks a pro-inflammatory brain environment that is not necessarily accompanied by neuronal loss.
tertiary and quaternary structure of the mitochondrial translocator protein TSPO, which binds cholesterol with nanomolar affinity, is affected by cholesterol.
Steroidogenic abnormalities in TSPO-knockout mice and significance in the aging male have been reported.
Results indicated that TSPO overexpression in the hippocampal dentate gyrus could significantly exert anxiolytic and antidepressant-like effects on behaviour. These effects were associated with allopregnanolone biosynthesis, which was at least partially mediated by TSPO.
TSPO is therefore proposed as a novel outer mitochondrial membrane-based pathway to control intracellular Ca(2+) dynamics and redox transients in neuronal cytotoxicity.
Critical role of TSPO in steroid biosynthesis and it may function at least in part via its regulation of DeltaPsim and effects on STAR.
Results showed that TSPO and other mitophagy related proteins, such as VDAC1, Pink1 and Beclin1 were significantly decreased by LH challenge. Moreover, KIFC2, relevant to the mitochondrial transport and Snap25, relevant to neurotransmitter vesicle release, were also obviously down-regulated in the LH mice, which further rendered supportive evidence for the existing mitochondrial dysfunction in LH mice.
A potential modulatory role of TSPO is in response to immune system deficit.
The expression of TSPO was found to be increased in the peri-hematomal brain region after intracerebral hemorrhage.
TSPO expression increases ( approximately 9-fold) in rodent-derived macrophages and microglia upon pro-inflammatory stimulation.
Data suggest that up-regulation of translocator protein 18kDa level during neuroinflammation may be an adaptive response mechanism, a way to provide more neurosteroids.
This study confirms TSPO deficiency does not affect viability and bronchial alveolar immune homeostasis.
These results suggested that Wuling powder exhibited an obvious antidepressant effect, which could be due to the improvement of TSPO-mediated mitophagy signaling pathway.
The loss of TSPO in the Central Nervous System did not result in overt developmental defects or phenotypes. The TSPO-/- mouse showed a decrease in glial fibrillary acidic protein expression, correlating with a decrease in astrogliosis in response to neural injury during Autoimmune Experimental Encephalomyelitis.
Study reviews the physiological functions of TSPO gene in the mitochondrial permeability transition pore, steroidogenesis and energy metabolism especially in knockout mice. [review]
Study highlights the 3D structure of mTSPO/PBR and in complex with PK11195 providing an important step towards a more detailed understanding of the molecular mechanism of mammalian TSPO/PBR and its interaction with small molecules. [review]
TSPO expression in Sandhoff disease mice is brain region-specific and depends on the age of the animal as disease progresses with the thalamus providing the earliest signal of disease based on TSPO expression and other markers of neurodegeneration
Authors investigated the link between mitochondrial TSPO and structural brain characteristics in key brain regions such as dorsolateral prefrontal cortex and hippocampus of a large group of participants including individuals at clinical high risk (CHR) for psychosis, first-episode psychosis (mostly antipsychotic-naive) patients, and healthy volunteers.
These data provide biochemical insights into TSPO-associated function in retinal pigment epithelial cells.
The translocator protein.
Study found no alcohol use disorder (AUD) group differences on [11C]PBR28 binding in our clinical study and no group differences in [11C]PBR28 uptake in the brain of alcohol-dependent versus -nondependent rats. However, when separately analyzing by TSPO genotype, found lower [11C]PBR28 binding in the brain of AUD patients than in healthy controls for medium-affinity binders only.
this study assessed the feasibility of utilizing PET imaging with the TSPO tracer, [18F]PBR06, to detect activated microglia in two HD mouse models and to monitor response to treatment with LM11A-31, a p75NTR ligand known to reduce neuroinflammation in HD mice.
Positron emission tomography (PET) radioligands for translocator protein 18 kDa (TSPO) are widely used to measure neuroinflammation, but controversy exists whether second-generation radioligands are superior to the prototypical agent (11)C-( R)-PK11195 in human imaging
This study demonstrated that TSPO was expressed in microglia and neurons in drug-resistant mesial temporal lobe epilepsy.
we tested whether rs6971 predicted variance in diurnal cortisol rhythm. Repeated measures ANOVA confirmed effects bipolar disorder(F5,525=3.0, p=0.010) and alcohol use disorders (F5,525=2.9, p=0.012), but not TSPO polymorphism (p>0.05). Interactions were confirmed for TSPOxbipolar disorder(F5,525=3.9, p=0.002) and for TSPOxalcohol use disorders (F5,525=2.8, p=0.017).
An increase in the expression levels of Tspo mRNA is not necessarily a good diagnostic biomarker in most cancers with changes not being large enough to be significantly different when detected by in situ hybridisation.
Suggest that altered TSPO distribution in the cerebellum, and potentially in other regions (e.g. the hippocampus), may be a marker of pathophysiology in systemic lupus erythematosus.
Effects of genetic variants in the TSPO gene on protein structure and stability
PET study found increased TSPO availability, suggestive of predominantly microglial activation, in the anterior cingulate cortex during a moderate to severe major depressive episode. A potential contribution of suicidality to the elevated TSPO in major depressive disorder warrants further research in adequately powered studies.
Study found significantly lower levels of activated microglia in the brains of living alcohol dependent subjects compared to healthy controls as measured with [11C]PBR28 PET. Importantly, exploratory analyses suggest that lower [11C]PBR28 VT values are associated with greater alcohol dependence severity and more reported drinks per day over the previous month.
Authors investigate the function of TSPO in cholesterol efflux from the RPE cells. We demonstrate in RPE cells that TSPO specific ligands promoted cholesterol efflux to acceptor (apo)lipoprotein and human serum, while loss of TSPO resulted in impaired cholesterol efflux.
suggest that both of the most important proapoptotic and anticancer proteins, p53 and TSPO
Study shows that fibromyalgia patients with the translocator protein high affinity binding genotype reported a higher pain intensity and more severe fibromyalgia symptoms compared to mixed/low affinity binders, and this was modulated by interaction with the serotonin transporter gene.
Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1.
TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis.
Findings suggest lower glial density or an altered activation state with lower TSPO expression in the hippocampus of alcohol dependent patients.
demonstrate a consistent down-regulation of TSPO mRNA and protein in macrophages activated to a pro-inflammatory, or 'M1' phenotype
PBR mRNA was the more abundant detected form in pig tissues and in warm kidney that underwent ischemia suggesting functional implications of PBR during the renal repair process.
Changes in TSPO expression in kidney regenerating tissue could be important for renal protection and maintenance of kidney function.
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported\; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.
peripheral-type benzodiazepine receptor
, Peripheral-type benzodiazepine receptor
, translocator protein
, benzodiazepine receptor, peripheral
, isoquinoline-binding protein
, mitochondrial benzodiazepine receptor
, Benzodiazepin receptor (peripheral)
, benzodiazepine peripheral binding site
, peripheral benzodiazepine receptor
, benzodiazepine receptor (peripheral)