Browse our anti-Peripheral-Type Benzodiazepine Receptor (TSPO) Antibodies

Full name:: anti-Peripheral-Type Benzodiazepine Receptor Antibodies (TSPO)

On www.antibodies-online.com are 84 Peripheral-Type Benzodiazepine Receptor (TSPO) Antibodies from 22 different suppliers available. Additionally we are shipping Peripheral-Type Benzodiazepine Receptor Kits (30) and Peripheral-Type Benzodiazepine Receptor Proteins (7) and many more products for this protein. A total of 133 Peripheral-Type Benzodiazepine Receptor products are currently listed.

Synonyms:: BPBS, Bzrp, DBI, IBP, LOC732875, LOC100136652, LOC100280949, MBR, mDRC, PBR, PBS, pk18, PKBS, PTBR, Ptbzr, PTBZR02, RATPTBZR02, TSPO, Tspo1

list all antibodies	Gene Name	GeneID	UniProt
	TSPO	12257	P50637
	TSPO	24230	P16257
	TSPO	706	P30536
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Most Popular Reactivities for anti-Peripheral-Type Benzodiazepine Receptor (TSPO) Antibodies

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anti-Mouse (Murine) Antibodies:

35 WB Antibodies

anti-Rat (Rattus) Antibodies:

12 WB Antibodies

anti-Human Antibodies:

All available anti-Peripheral-Type Benzodiazepine Receptor Antibodies

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Top referenced anti-Peripheral-Type Benzodiazepine Receptor Antibodies

Human Polyclonal TSPO Primary Antibody for ICC, IF - ABIN188570 : Fafalios, Akhavan, Parwani, Bies, McHugh, Pflug: Translocator protein blockade reduces prostate tumor growth. in Clinical cancer research : an official journal of the American Association for Cancer Research 2009 (PubMed)
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Human Polyclonal TSPO Primary Antibody for IHC, WB - ABIN4343997 : Foss, Liu, Mease, Wang, Pasricha, Pomper: Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with (125)I-Iodo-DPA-713 SPECT/CT. in Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2017 (PubMed)
Mouse (Murine) Polyclonal TSPO Primary Antibody for ELISA, WB - ABIN4343998 : Weisinger, Kelly-Hershkovitz, Veenman, Spanier, Leschiner, Gavish: Peripheral benzodiazepine receptor antisense knockout increases tumorigenicity of MA-10 Leydig cells in vivo and in vitro. in Biochemistry 2004 (PubMed)
Human Polyclonal TSPO Primary Antibody for ELISA, FACS - ABIN570960 : Morgan, Cheepala, Wang, Neale, Adachi, Nachagari, Leggas, Zhao, Boyd, Venkataramanan, Schuetz: Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice. in The Journal of biological chemistry 2012 (PubMed)
Human Polyclonal TSPO Primary Antibody for IHC, WB - ABIN222898 : Ji, Maeda, Sawada, Ono, Okauchi, Inaji, Zhang, Suzuki, Ando, Staufenbiel, Trojanowski, Lee, Higuchi, Suhara: Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 (PubMed)

More Antibodies against Peripheral-Type Benzodiazepine Receptor Interaction Partners

Mouse (Murine) Peripheral-Type Benzodiazepine Receptor (TSPO) interaction partners

tertiary and quaternary structure of the mitochondrial translocator protein TSPO, which binds cholesterol with nanomolar affinity, is affected by cholesterol.
Steroidogenic abnormalities in TSPO-knockout mice and significance in the aging male have been reported.
Results indicated that TSPO overexpression in the hippocampal dentate gyrus could significantly exert anxiolytic and antidepressant-like effects on behaviour. These effects were associated with allopregnanolone biosynthesis, which was at least partially mediated by TSPO.
TSPO is therefore proposed as a novel outer mitochondrial membrane-based pathway to control intracellular Ca(2 (show CA2 Antibodies)+) dynamics and redox transients in neuronal cytotoxicity.
Critical role of TSPO in steroid biosynthesis and it may function at least in part via its regulation of DeltaPsim and effects on STAR.
Results showed that TSPO and other mitophagy related proteins, such as VDAC1 (show VDAC1 Antibodies), Pink1 (show PINK1 Antibodies) and Beclin1 (show BECN1 Antibodies) were significantly decreased by LH challenge. Moreover, KIFC2 (show KIFC2 Antibodies), relevant to the mitochondrial transport and Snap25 (show SNAP25 Antibodies), relevant to neurotransmitter vesicle release, were also obviously down-regulated in the LH mice, which further rendered supportive evidence for the existing mitochondrial dysfunction in LH mice.
A potential modulatory role of TSPO is in response to immune system deficit.
The expression of TSPO was found to be increased in the peri (show POSTN Antibodies)-hematomal brain region after intracerebral hemorrhage.
TSPO expression increases ( approximately 9-fold) in rodent-derived macrophages and microglia upon pro-inflammatory stimulation.
Data suggest that up-regulation of translocator protein 18kDa level during neuroinflammation may be an adaptive response mechanism, a way to provide more neurosteroids.

Human Peripheral-Type Benzodiazepine Receptor (TSPO) interaction partners

An increase in the expression levels of Tspo mRNA is not necessarily a good diagnostic biomarker in most cancers with changes not being large enough to be significantly different when detected by in situ hybridisation.
Suggest that altered TSPO distribution in the cerebellum, and potentially in other regions (e.g. the hippocampus), may be a marker of pathophysiology in systemic lupus erythematosus.
Effects of genetic variants in the TSPO gene on protein structure and stability
PET study found increased TSPO availability, suggestive of predominantly microglial activation, in the anterior cingulate cortex during a moderate to severe major depressive episode. A potential contribution of suicidality to the elevated TSPO in major depressive disorder warrants further research in adequately powered studies.
Authors investigate the function of TSPO in cholesterol efflux from the RPE cells. We demonstrate in RPE cells that TSPO specific ligands promoted cholesterol efflux to acceptor (apo)lipoprotein and human serum, while loss of TSPO resulted in impaired cholesterol efflux.
suggest that both of the most important proapoptotic and anticancer proteins, p53 and TSPO
Study shows that fibromyalgia patients with the translocator protein high affinity binding genotype reported a higher pain intensity and more severe fibromyalgia symptoms compared to mixed/low affinity binders, and this was modulated by interaction with the serotonin transporter (show SLC6A4 Antibodies) gene.
Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1.
TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis.
Findings suggest lower glial density or an altered activation state with lower TSPO expression in the hippocampus of alcohol dependent patients.

Pig (Porcine) Peripheral-Type Benzodiazepine Receptor (TSPO) interaction partners

PBR mRNA was the more abundant detected form in pig tissues and in warm kidney that underwent ischemia suggesting functional implications of PBR during the renal repair process.
Changes in TSPO expression in kidney regenerating tissue could be important for renal protection and maintenance of kidney function.

Peripheral-Type Benzodiazepine Receptor (TSPO) Antigen Profile

Antigen Summary

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported\; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.

Alternative names and synonyms associated with Peripheral-Type Benzodiazepine Receptor (TSPO)

peripheral-type benzodiazepine receptor (LOC732875) antibody
peripheral-type benzodiazepine receptor (MAV_3896) antibody
Peripheral-type benzodiazepine receptor (xccb100_2086) antibody
putative peripheral-type benzodiazepine receptor (Smp_102510) antibody
peripheral-type benzodiazepine receptor (Sros_1911) antibody
translocator protein (tspo) antibody
translocator protein homolog (LOC100280949) antibody
hypothetical protein (PGTG_16395) antibody
translocator protein (TSPO) antibody
translocator protein (Tspo) antibody

BPBS antibody
Bzrp antibody
DBI antibody
IBP antibody
LOC732875 antibody
LOC100136652 antibody
LOC100280949 antibody
MBR antibody
mDRC antibody
PBR antibody
PBS antibody
pk18 antibody
PKBS antibody
PTBR antibody
Ptbzr antibody
PTBZR02 antibody
RATPTBZR02 antibody
TSPO antibody
Tspo1 antibody

Protein level used designations for TSPO

peripheral-type benzodiazepine receptor , Peripheral-type benzodiazepine receptor , translocator protein , PKBS , benzodiazepine receptor, peripheral , isoquinoline-binding protein , mitochondrial benzodiazepine receptor , Benzodiazepin receptor (peripheral) , PBR , benzodiazepine peripheral binding site , peripheral benzodiazepine receptor , IBP , benzodiazepine receptor (peripheral)

GENE ID	SPECIES
732875	Bombyx mori
4529395	Mycobacterium avium 104
6322197	Xanthomonas campestris pv. campestris str. B100
8346408	Schistosoma mansoni
8665189	Streptosporangium roseum DSM 43021
100136652	Oncorhynchus mykiss
100280949	Zea mays
10528866	Puccinia graminis f. sp. tritici CRL 75-36-700-3
443123	Ovis aries
12257	Mus musculus
24230	Rattus norvegicus
706	Homo sapiens
396592	Sus scrofa
281033	Bos taurus
474475	Canis lupus familiaris
418226	Gallus gallus
100722263	Cavia porcellus
100338710	Oryctolagus cuniculus

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Show all anti-Peripheral-Type Benzodiazepine Receptor (TSPO) Antibodies with Pubmed References