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Human Polyclonal TSPO Primary Antibody for ICC, IF - ABIN188570
Fafalios, Akhavan, Parwani, Bies, McHugh, Pflug: Translocator protein blockade reduces prostate tumor growth. in Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Show all 7 Pubmed References
Mouse (Murine) Polyclonal TSPO Primary Antibody for ELISA, WB - ABIN570960
Morgan, Cheepala, Wang, Neale, Adachi, Nachagari, Leggas, Zhao, Boyd, Venkataramanan, Schuetz: Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice. in The Journal of biological chemistry 2012
Human Polyclonal TSPO Primary Antibody for IHC, WB - ABIN222898
Ji, Maeda, Sawada, Ono, Okauchi, Inaji, Zhang, Suzuki, Ando, Staufenbiel, Trojanowski, Lee, Higuchi, Suhara: Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Human Polyclonal TSPO Primary Antibody for IHC, WB - ABIN4343997
Foss, Liu, Mease, Wang, Pasricha, Pomper: Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with (125)I-Iodo-DPA-713 SPECT/CT. in Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2017
Mouse (Murine) Polyclonal TSPO Primary Antibody for ELISA, WB - ABIN4343998
Weisinger, Kelly-Hershkovitz, Veenman, Spanier, Leschiner, Gavish: Peripheral benzodiazepine receptor antisense knockout increases tumorigenicity of MA-10 Leydig cells in vivo and in vitro. in Biochemistry 2004
Results indicated that TSPO overexpression in the hippocampal dentate gyrus could significantly exert anxiolytic and antidepressant-like effects on behaviour. These effects were associated with allopregnanolone biosynthesis, which was at least partially mediated by TSPO.
TSPO is therefore proposed as a novel outer mitochondrial membrane-based pathway to control intracellular Ca(2 (show CA2 Antibodies)+) dynamics and redox transients in neuronal cytotoxicity.
Critical role of TSPO in steroid biosynthesis and it may function at least in part via its regulation of DeltaPsim and effects on STAR.
Results showed that TSPO and other mitophagy related proteins, such as VDAC1 (show VDAC1 Antibodies), Pink1 (show PINK1 Antibodies) and Beclin1 (show BECN1 Antibodies) were significantly decreased by LH challenge. Moreover, KIFC2 (show KIFC2 Antibodies), relevant to the mitochondrial transport and Snap25 (show SNAP25 Antibodies), relevant to neurotransmitter vesicle release, were also obviously down-regulated in the LH mice, which further rendered supportive evidence for the existing mitochondrial dysfunction in LH mice.
A potential modulatory role of TSPO is in response to immune system deficit.
The expression of TSPO was found to be increased in the peri (show POSTN Antibodies)-hematomal brain region after intracerebral hemorrhage.
TSPO expression increases ( approximately 9-fold) in rodent-derived macrophages and microglia upon pro-inflammatory stimulation.
Data suggest that up-regulation of translocator protein 18kDa level during neuroinflammation may be an adaptive response mechanism, a way to provide more neurosteroids.
This study confirms TSPO deficiency does not affect viability and bronchial alveolar immune homeostasis.
These results suggested that Wuling powder exhibited an obvious antidepressant effect, which could be due to the improvement of TSPO-mediated mitophagy signaling pathway.
Effects of genetic variants in the TSPO gene on protein structure and stability
PET study found increased TSPO availability, suggestive of predominantly microglial activation, in the anterior cingulate cortex during a moderate to severe major depressive episode. A potential contribution of suicidality to the elevated TSPO in major depressive disorder warrants further research in adequately powered studies.
Authors investigate the function of TSPO in cholesterol efflux from the RPE cells. We demonstrate in RPE cells that TSPO specific ligands promoted cholesterol efflux to acceptor (apo)lipoprotein and human serum, while loss of TSPO resulted in impaired cholesterol efflux.
suggest that both of the most important proapoptotic and anticancer proteins, p53 and TSPO
Study shows that fibromyalgia patients with the translocator protein high affinity binding genotype reported a higher pain intensity and more severe fibromyalgia symptoms compared to mixed/low affinity binders, and this was modulated by interaction with the serotonin transporter (show SLC6A4 Antibodies) gene.
Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1.
TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis.
Findings suggest lower glial density or an altered activation state with lower TSPO expression in the hippocampus of alcohol dependent patients.
demonstrate a consistent down-regulation of TSPO mRNA and protein in macrophages activated to a pro-inflammatory, or 'M1' phenotype
These findings have important implications for understanding the biology of TSPO in activated macrophages and microglia in humans.
PBR mRNA was the more abundant detected form in pig tissues and in warm kidney that underwent ischemia suggesting functional implications of PBR during the renal repair process.
Changes in TSPO expression in kidney regenerating tissue could be important for renal protection and maintenance of kidney function.
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported\; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.
peripheral-type benzodiazepine receptor
, Peripheral-type benzodiazepine receptor
, translocator protein
, benzodiazepine receptor, peripheral
, isoquinoline-binding protein
, mitochondrial benzodiazepine receptor
, Benzodiazepin receptor (peripheral)
, benzodiazepine peripheral binding site
, peripheral benzodiazepine receptor
, benzodiazepine receptor (peripheral)