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MRI characteristics, such as lesion border, lesion edema degree, enhancement degree of the lesion and deep white matter invasion, might be associated with BAF53a expression in gliomas
Results suggested that BAF53A plays an important role in the expression of androgen receptor target genes in prostate cancer
Our findings indicate that ACTL6A exhibits pro-tumor function and acts as an EMT activator in colon cancer. ACTL6A may serve as a potential therapeutic target for colon cancer.
hese results suggest that BAF53a may be a novel prognostic factor for glioma patients, and that BAF53 may facilitate glioma progression by promoting proliferation, invasion, and associate with EMT. Therefore, BAF53a could be a potential promising biomarker and a target for the treatment of glioma.
ACTL6A gene mutation analysis should be considered in patients with intellectual disability, learning disabilities, or developmental language disorder.
ACTL6A and p63 collaborate as oncogenic drivers in head and neck squamous cell carcinoma (HNSCC).
Study shows high expression level of ACTL6A in osteosarcoma tissues and associates with poor survival providing evidence that ACTL6A promotes osteosarcoma cell metastasis through epithelial-mesenchymal transition.
ACTL6A protein expression predicts poor prognosis of hepatocellular carcinoma and metastasis.
BAF53 is prerequisite for maintaining the structural integrity of chromosomal subdomains.
These results indicate that failure to downregulate the BAF53a subunit may contribute to the pathogenesis of rhabdomyosarcoma, and suggest that BAF53a may represent a novel therapeutic target for this tumor.
Data show that ACTL6a prevents SWI/SNF complex binding to promoters of KLF4 and other differentiation genes and that SWI/SNF catalytic subunits are required for full induction of KLF4 targets.
The beta-actin-Arp4 complex formation might be a crucial feature in some chromatin-modifying enzyme complexes, such as the Brg1 complex.
These results suggest that activated expression of the E6 and E7 genes of integrated HPV is dependent on BAF53-dependent higher-order chromatin structure or nuclear motor activity.
study finds Baf53 and Baf170 are highly regulated in HIV-1-infected cells;innate function of Baf53-containing complexes appears to be transcriptionally suppressive
data show that BAF53 shuttles between the cytoplasm and nucleus in an energy-dependent manner, and suggest that BAF53 can play a role distinct from its previously recognized function in transcriptional regulation
Results suggest that brain derived neurotrophic factor (BDNF) activation in the nucleus accumbens (NAc) may overcome memory and plasticity deficits linked to Actl6a protein (BAF53b) mutations.
uncover a novel function of Actl6a in mouse embryonic stem cells (mESCs), where it acts as a gatekeeper to prevent mESCs from entering into the primitive endoderm lineage through a Yin/Yang regulating pattern
Data indicate an essential role for the BAF53a subunit of BAF complexes in the development of hematopoiesis system.
data show that BAF53 shuttles between the cytoplasm and nucleus in an energy-dependent manner, and suggest that BAF53 can play a role distinct from its previously recognized function in transcriptional regulation [BAf53]
These results indicate that BAF53 contributes to the polymeric properties and/or the internal meshwork interactions of the chromatin fiber probably via a novel mechanism.
BAF53 is associated with mitotic chromosomes during mitosis.
Mitotic exit in neurons is accompanied by an essential switch in ATP-dependent chromatin regulatory complexes from the neural progenitor Brg/Brm-associated factor (npBAF) to neuron-specific nBAF
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila\; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
53 kDa BRG1-associated factor A
, BAF complex 53 kDa subunit
, BRG1-associated factor 53A
, INO80 complex subunit K
, actin-like protein 6A
, actin-related protein 4
, actin-related protein Baf53a
, hArpN beta
, BRG1/brm-associated factor 53A
, actin-like 6
, actin-like 6A
, actin-like protein 6A-like
, Actin-like protein ARP4
, actin like 6A L homeolog
, actin like 6A S homeolog
, actin-related protein