Browse our RAG2 Proteins (RAG2)

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

• recombination activating 2 (RAG2)
• recombination activating gene 2 (RAG2)
• recombination activating gene 2 (Rag2)
• recombination activating 2 (Rag2)
• recombination activating gene 2 (rag2)
• Show all gene names
• recombination activating gene 2 S homeolog (rag2.S)

• rag-2 protein
• zgc:136743 protein

recombination activating gene 2 , recombination activating protein 2 , V(D)J recombination-activating protein 2-like , V(D)J recombination-activating protein 2 , recombinase activating gene 2 , v(D)J recombination-activating protein 2 , RAG-2