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Human Kallikrein 1 Protein expressed in Wheat germ - ABIN1308832
Kahn, Hellmark, Leeb-Lundberg, Akbari, Todiras, Olofsson, Wieslander, Christensson, Westman, Bader, Müller-Esterl, Karpman: Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin. in Journal of immunology (Baltimore, Md. : 1950) 2009
Recognition of anti-tumor necrosis factor-alpha (TNF-alpha) or Kallikrein Inhibitor may lead to therapeutics to enhance existing treatments for patients who do not respond to anti-vascular endothelial growth factor (VEGF) therapies.
increasing the serum levels of AngII increased the risk of acute myocardial infarction (AMI (show CFD Proteins)); the risk of AMI (show CFD Proteins) increased when the serum levels of AngII and KLK1 simultaneously increased; individuals with the combined genotypes of ACE (show ACE Proteins) DD and KLK1 GG showed increased risk of AMI (show CFD Proteins) compared with those with the combined genotypes of ACE (show ACE Proteins) II and KLK1 AA
The rs5516 G allele of KLK1 was significantly associated with aortic aneurysm
KLK1 rs5516 SNP is not related to the incidence of Alzheimer's disease in a Hunan Han Chinese population.
TK promoted cell survival and beta-catenin (show CTNNB1 Proteins) degradation in serum-starved SH-SY5Y cells via increasing autophagy.
Our findings suggest that higher levels of TK in plasma are associated with the presence of CAD and are a predictor of mild coronary arteriosclerosis.
The kallikrein (show KLK4 Proteins) system in retinal damage/protection
Preclinical characterization of recombinant human tissue kallikrein-1 as a novel treatment for type 2 diabetes mellitus.
Up-regulation of KLK1 in tubular epithelial cells may mediate pro-inflammatory pathway and PAR (show JTB Proteins) activation during diabetic nephropathy.
These data do not support a role for the Tissue kallikrein-kinin system, protective or deleterious, in the develop (show INS Proteins)ment of insulin resistance and diabetes.
Polypeptides identified based on immunorecognition by autoantibodies in sera from IQI/Jic mice affected with autoimmune disease (>12 weeks of age) were tissue kallikrein (Klk)-1 and -13 and were cross-reactive to the autoantibodies.
Protective effects of Tissue kallikrein gene transfer on ischemic diseases.
TK, like several other proteases, can activate ENaC (show SCNN1A Proteins) in the kidney and the colon.
Tissue kallikrein and kinins do not influence the trophicity of kidneys, the synthesis and secretion of renin (show REN Proteins), blood pressure increase, and cardiac remodeling due to renin (show REN Proteins) angiotensin system activation.
tissue kallikrein knockout mice had a significant two-fold increase in albuminuria
The study suggests that kallikrein plays an antihypertensive role in hyperaldosteronism.
These data do not support a role for the TK-kinin system, protective or deleterious, in the development of insulin (show INS Proteins) resistance and diabetes.
Lower excretion of active renin (show REN Proteins) and prorenin in TK(-/-) compared to TK(+/+) suggest coordinated regulation of the two proteins in their participation to collecting duct function.
Plasma kallikrein (show KLKB1 Proteins)-deficient mice challenged with transient middle cerebral artery occlusion developed significantly smaller brain infarctions.
The data of this study presented support the conclusion that Klk6 is an important participant in the immunopathogenic events that drive TMEV-IDD (show DGS2 Proteins) at acute through early chronic time points.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
glandular kallikrein 1
, kallikrein 1, renal/pancreas/salivary
, kallikrein serine protease 1
, kidney/pancreas/salivary gland kallikrein
, tissue kallikrein
, kallikrein 1
, glandular kallikrein
, glandular kallikrein K1
, kallikrein 6
, kallikrein renal/pancreas/salivary
, renal kallikrein
, tissue kallikrein-6
, true tissue kallikrein
, PS kallikrein
, kallikrein 1-related peptidase b3
, nerve growth factor gamma chain
, nerve growth factor gamma polypeptide
, pancreatic kallikrein