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anti-Human Prothrombin Antibodies:
anti-Mouse (Murine) Prothrombin Antibodies:
anti-Rat (Rattus) Prothrombin Antibodies:
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Human Monoclonal Prothrombin Primary Antibody for ELISA, WB - ABIN2192473
Yin, Wright, Wall, Grammas: Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease. in The American journal of pathology 2010
Show all 2 Pubmed References
Human Polyclonal Prothrombin Primary Antibody for CyTOF, FACS - ABIN4900737
Jesmin, Gando, Zaedi, Prodhan, Sawamura, Miyauchi, Hiroe, Yamaguchi: Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure. in Shock (Augusta, Ga.) 2009
Human Polyclonal Prothrombin Primary Antibody for IF, WB - ABIN515438
Huang, Wu, Tseng, Chen, Hsieh, Chen: Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. in PLoS ONE 2011
digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns.
Prothrombin gene mutation is rare in Budd-Chiari syndrome patients in India.
In HBV-related cirrhosis, the combination of miR (show MLXIP Antibodies)-122, AFP (show AFP Antibodies) and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.
Data, including data using network analysis, suggest that angiotensinogen (AGT (show AGT Antibodies)), mitogen-activated protein kinase-14 (MAPK14 (show MAPK14 Antibodies)), and prothrombin (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.
Arg596Gln mutation is a risk factor for Chinese patients with venous thromboembolism due to its moderately decreased clotting activity but strong resistance to antithrombin (show SERPINC1 Antibodies) inhibition.
The induction of TG by BXPC3 cells was mainly driven by the TF pathway while TG generation triggered by MCF7 cells was also driven by FXII (show F12 Antibodies) activation.
we were not able to confirm the association between the polymorphisms of f5, f2, and mthfr (show MTHFR Antibodies) and pregnancy loss in Bosnian women
Platelets were activated in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients, and such activation was at least partially attributed to the thrombin-protease-activated receptors (PARs (show EPRS Antibodies)) pathway.
The meta-analysis enabled us to underline the importance of DCP (show ACE Antibodies) in the refinement of the eligibility criteria of hepatocellular cancer (HCC (show FAM126A Antibodies))patients for liver transplant (LT). This information, based on Japanese studies performed in the setting of living-donor LT only, needs further validation in the Western world both in the setting of post-mortem and living-donor LT.
HCC (show FAM126A Antibodies) [hepatocellular carcinoma] patients who are sero-positive for DCP (show ACE Antibodies) [Des (show DES Antibodies)-gamma-carboxyprothrombin] and sero-negative for AFP (show AFP Antibodies)[Alpha-fetoprotein (show AFP Antibodies)] have significantly higher levels of serum ALT[alanine aminotransferase (show ALT Antibodies)]; serum ALT levels may be of diagnostic importance in AFP (show AFP Antibodies)-negative, HBV-related HCC (show FAM126A Antibodies) [hepatitis B virus-related hepatocellular carcinoma] patients.
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (show BGN Antibodies) plays a protective role during the progression of atherosclerosis in ApoE (show APOE Antibodies)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (show GP1BA Antibodies)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (show MARK2 Antibodies) interaction regulated MCP-1 (show CPT1B Antibodies), TF, MCSF (show CSF1 Antibodies) and IL-6 (show IL6 Antibodies) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (show SERPINC1 Antibodies) nanoparticle therapeutics.
Thrombin-PAR1 (show F2R Antibodies) signaling, via nitric oxide and EPCR (show PROCR Antibodies), promotes hematopoietic stem cell (HSC (show FUT1 Antibodies)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (show CDC25C Antibodies) and Ras-associating domains of phospholipase C epsilon (show PLCE1 Antibodies).
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (show SULF1 Antibodies) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (show SULF1 Antibodies) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (show MAPK1 Antibodies), MSK1 (show RPS6KA5 Antibodies), and NF-kappaB (show NFKB1 Antibodies) play important roles in thrombin-induced iNOS (show NOS2 Antibodies) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (show F2R Antibodies)) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 Antibodies)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (show UGDH Antibodies) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (show F10 Antibodies) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (show UGDH Antibodies) and by receptor-mediated up-regulation of factor XIII (show UGDH Antibodies) synthesis
In conclusion, thrombin activates pro-MMP-2 (show MMP2 Antibodies) in the absence of elevated pro-MMP-2 (show MMP2 Antibodies) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (show MMP2 Antibodies)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (show F2R Antibodies), RhoA (show RHOA Antibodies), and myocardin (show MYOCD Antibodies).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2