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anti-Human Prothrombin Antibodies:
anti-Mouse (Murine) Prothrombin Antibodies:
anti-Rat (Rattus) Prothrombin Antibodies:
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Human Monoclonal Prothrombin Primary Antibody for ELISA, WB - ABIN2192473
Yin, Wright, Wall, Grammas: Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease. in The American journal of pathology 2010
Show all 2 Pubmed References
Human Polyclonal Prothrombin Primary Antibody for IHC, ELISA - ABIN1583288
Fritze, Zhang, Li, Chai, Mulholland: Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2014
Human Polyclonal Prothrombin Primary Antibody for CyTOF, FACS - ABIN4900737
Jesmin, Gando, Zaedi, Prodhan, Sawamura, Miyauchi, Hiroe, Yamaguchi: Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure. in Shock (Augusta, Ga.) 2009
Human Polyclonal Prothrombin Primary Antibody for WB - ABIN515439
Huang, Wu, Tseng, Chen, Hsieh, Chen: Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. in PLoS ONE 2011
this study demonstrated that thrombin and factor Xa cleavage sites on HEV pORF1 are obligatory for HEV replication.
increased frequency of factor V Leiden (show F5 Antibodies) G1691A and prothrombin G20210A mutation in venous thromboembolism patients indicates a significant role of these mutations in the development of VTE in the Kashmiri population
The results suggest that an increased plasma thrombin potential is characteristic in patients with clinically stable coronary artery disease, irrespective of previous myocardial infarction history and independent of traditional cardiovascular risk factors.
Enhanced thrombin generation is driven in asthma by a systemic inflammatory state mediated by IL-6 (show IL6 Antibodies) and to a lesser extent TNFalpha (show TNF Antibodies), however, not periostin (show POSTN Antibodies). TNFalpha (show TNF Antibodies) might contribute to impaired fibrinolysis.
Endogenous thrombin potential measured in presence of thrombomodulin (show THBD Antibodies) is enhanced in patients with intracranial atherosclerotic disease (ICAD (show DFFA Antibodies)), supporting that thrombomodulin (show THBD Antibodies)-protein C (show PROC Antibodies) pathways is relevant in transient ischaemic attacks from ICAD (show DFFA Antibodies).
PIVKA II, when combined with AFP (show AFP Antibodies), may be considered as a screening test for hepatocellular carcinoma due to its high negative predictive value.
Thrombin activated platelet releasing exosomes convey miRNA between cells. miRNA-223 regulates the expression of molecules adhesion including ICAM-1 (show ICAM1 Antibodies). miRNA-223 downregulated ICAM-1 (show ICAM1 Antibodies) mainly by impacting NF-kappaB (show NFKB1 Antibodies) and the MAPK (show MAPK1 Antibodies) pathway.
Thrombin binding to extra-cellular loop II (ECLII) of PAR4 (show PAWR Antibodies) is important for its cleavage and activation of PAR4 (show PAWR Antibodies).
These findings suggest that contraction-dependent TGF-beta (show TGFB1 Antibodies) activation could be a mechanism by which thrombin leads to the development of asthmatic airway remodeling.
Case Report: Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation I prothrombin.
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (show BGN Antibodies) plays a protective role during the progression of atherosclerosis in ApoE (show APOE Antibodies)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (show GP1BA Antibodies)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (show MARK2 Antibodies) interaction regulated MCP-1 (show CPT1B Antibodies), TF, MCSF (show CSF1 Antibodies) and IL-6 (show IL6 Antibodies) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (show SERPINC1 Antibodies) nanoparticle therapeutics.
Thrombin-PAR1 (show F2R Antibodies) signaling, via nitric oxide and EPCR (show PROCR Antibodies), promotes hematopoietic stem cell (HSC (show FUT1 Antibodies)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (show CDC25C Antibodies) and Ras-associating domains of phospholipase C epsilon (show PLCE1 Antibodies).
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (show SULF1 Antibodies) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (show SULF1 Antibodies) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (show MAPK1 Antibodies), MSK1 (show RPS6KA5 Antibodies), and NF-kappaB (show NFKB1 Antibodies) play important roles in thrombin-induced iNOS (show NOS2 Antibodies) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (show F2R Antibodies)) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 Antibodies)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (show UGDH Antibodies) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (show F10 Antibodies) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (show UGDH Antibodies) and by receptor-mediated up-regulation of factor XIII (show UGDH Antibodies) synthesis
In conclusion, thrombin activates pro-MMP-2 (show MMP2 Antibodies) in the absence of elevated pro-MMP-2 (show MMP2 Antibodies) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (show MMP2 Antibodies)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (show F2R Antibodies), RhoA (show RHOA Antibodies), and myocardin (show MYOCD Antibodies).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2