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In embryos defective for S1pr2/Galpha13 signaling, endocardial precursors failed to migrate towards the midline, and the presumptive endocardium surrounded the bilaterally-located myocardial cells rather than being encompassed by them.
Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA
S1pr2/Galpha13 signaling controls myocardial migration by regulating endoderm convergence.
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.
Results found that increased expression levels of GNA13 promoted cell growth, migration, invasion, and epithelial-mesenchymal transition, whereas GNA13 silencing abrogated these malignant phenotypes. In addition, overexpressing GNA13 in cancer cells increased the levels of the chemokines CXCL1, CXCL2, and CXCL4 via NF-kB signaling pathway, which contributed to colorectal cancer (CRC) proliferation and colony formation.
GNA13 protein expression was an independent prognostic factor and may affect disease progression in follicular lymphoma.
GTPase-deficient G-ALPHA-qQL and Galpha13QL variants formed stable complexes with G protein beta gamma, impairing its interaction with P-REX1.
GNA13 expression is a potential prognostic biomarker for tumor progression, and interfering with GNA13-induced signaling provides a novel strategy to block Tumor-initiating phenotypes and drug resistance in head and neck squamous cell carcinoma.
High expression of GNA13 is associated with hepatocellular carcinoma.
The ability of enhanced GNA13 signaling to suppress KLK gene expression appears at least in part due to the ability of enhanced GNA13 signaling to negatively impact Rho/ROCK-signaling.
the selective expression of FZD10 in brain vascular endothelial cells points at a potential role of FZD10-Galpha13 signalling in central nervous system angiogenesis.
The protein profile indicates attenuation of "GNA13-ERK signaling" in schizophrenia brain. In particular, EIF4G2 and CYFIP1, which are located downstream of the GNA13-ERK network, were decreased, suggesting that the attenuation of this signal network may cause impairment of axon formation and synapse plasticity in the brain of schizophrenia patients.
Findings indicate a tumor suppressive role for G protein subunit alpha 13 (Galpha13) and rhoA GTP-binding protein (RhoA) in Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL).
Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13)
Upregulation of GNA13 expression increased the proliferation and tumorigenicity of gastric cancer.
Knockdown DDR1 reversed the effects of Galpha13 knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen.
RGS22 acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13.
Galpha13 Switch Region 2 Binds to the Talin Head Domain and Activates alphaIIbbeta3 Integrin in Human Platelets
GNA13 expression in breast cancer cells is regulated by post-transcriptional mechanisms involving miR-31.
Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1) at extracellular loop 2 (ECL2) controls G12/13 versus Gq G-proteins coupling specificity in response to thrombin stimulation.
Our findings highlight the important role of miR-29c in regulating CRC EMT via GSK-3b/b-catenin signaling by targeting GNA13 and PTP4A and provide new insights into the metastatic basis of colorectal cancer
These results place Blk upstream of the p190RhoGAP-RhoA pathway in Galpha13-activated cells, overall representing an opposing signaling module during CXCL12-triggered invasion.
findings identify a Galpha13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma
Findings indicate lysophosphatidic acid (LPA)-lysophosphatidic acid receptor-Galpha13 signaling node as a therapeutic target for pancreatic cancer treatment and control.
results define Galpha13 as a switch regulator of myofiber reprogramming, implying that modulations of Galpha13 and its downstream effectors in skeletal muscle are a potential therapeutic approach to treating metabolic diseases.
This study demonstrated an almost 100-fold higher agonist sensitivity of the Galpha13 LARG interaction compared to the Galpha13 activation in the absence of LARG.
GNA13 loss is associated with GC B-cell persistence, in which impaired apoptosis and ongoing somatic hypermutation may lead to an increased risk of lymphoma development.
Selective inhibition of G12/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.
Direct Galpha13 binding to ITGB3 cytoplasmic domain regulates integrin outside-in signaling and thrombus formation in platelets.
Galpha 13 is activated in sensory neurons mediated by lysophosphatidylinositol.
Galpha13 binding to VE-cadherin mediates VE-cadherin internalization and endothelial barrier disruption and inflammation.
Data indicate that Pyk2 is a common signaling effector downstream of both G12/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.
Endothelial G13 regulates VEGFR-2 promoter activity through NF-kappaB activation.
Our data show that the G(12/13) family of heterotrimeric G proteins is centrally involved in pressure overload-induced cardiac remodeling and plays a central role in the transition to heart failure.
Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase
new insight into the mechanism by which p115RhoGEF is activated by Galpha(13).
A functional role for JLP in the gep oncogene-regulated neoplastic signaling pathway.
Galpha(12/13) regulate AP-1-dependent CYR61 induction in vascular smooth muscle, promoting migration, and they are upregulated with CYR61 in arteriosclerotic lesions.
propose here a novel cascade of PAR1-induced Galpha(13)-DVL axis in cancer and beta-catenin stabilization
In mouse pancreatic acini Galpha13 links cholecystokinin stimulation to activation of RhoA and Rac1 and amylase secretion.
study demonstrates not only a function of integrin alphaIIbbeta3 as a noncanonical Galpha13-coupled receptor but also a new concept of Galpha13-dependent dynamic regulation of RhoA
The G alpha(12)-mediated signaling pathway functionally interacts not only with the G alpha(13)- but also with the G alpha(q/11)-mediated signaling systems.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
guanine nucleotide binding protein, alpha 13
, guanine nucleotide-binding protein subunit alpha-13
, Galpha 13a
, Galpha 13b
, G-protein alpha 13b
, guanine nucleotide binding protein (G protein), alpha 13
, guanine nucleotide-binding protein subunit alpha-13-like
, G-protein subunit alpha-13
, g alpha-13