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anti-Human ITGA3 Antibodies:
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Mouse (Murine) Polyclonal ITGA3 Primary Antibody for CyTOF, FACS - ABIN4900246
Wang, Huang, Nayak, Matthews, Warburton, Shi, Sanchez-Esteban: Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin ?6?1-ADAM17/tumor necrosis factor-?-converting enzyme (TACE) signaling pathway. in The Journal of biological chemistry 2013
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Human Monoclonal ITGA3 Primary Antibody for CyTOF, FACS - ABIN4900792
Seltmann, Cheng, Wiche, Eriksson, Magin: Keratins Stabilize Hemidesmosomes through Regulation of β4-Integrin Turnover. in The Journal of investigative dermatology 2015
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Human Monoclonal ITGA3 Primary Antibody for FACS - ABIN4898623
Pytlík, Stehlík, Soukup, Kalbácová, Rypácek, Trc, Mulinková, Michnová, Kideryová, Zivný, Klener, Veselá, Trnený, Klener: The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering. in Biomaterials 2009
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Mouse (Murine) Polyclonal ITGA3 Primary Antibody for FACS - ABIN4897427
Elloumi-Hannachi, García, Shekeran, García: Contributions of the integrin β1 tail to cell adhesive forces. in Experimental cell research 2015
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Human Monoclonal ITGA3 Primary Antibody for FACS - ABIN2480714
Zanin-Zhorov, Nussbaum, Franitza, Cohen, Lider: T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003
Human Monoclonal ITGA3 Primary Antibody for FACS, ICC - ABIN4900665
Stawikowski, Aukszi, Stawikowska, Cudic, Fields: Glycosylation modulates melanoma cell α2β1 and α3β1 integrin interactions with type IV collagen. in The Journal of biological chemistry 2014
Bioinformatics analysis identifies ITGA3 as an oncogene in human tongue cancer.
these findings suggest that ITGA3 may play a role as a potential oncogene in intrahepatic cholangiocarcinoma (ICC)and suppression of ITGA3 expression may establish a novel target for guiding the therapy of ICC patients.
During the past decades, many studies have provided evidence for a role of laminin-binding integrins in tumorigenesis, and both tumor-promoting and suppressive activities have been identified. (Review)
ITGA3 mutation is responsible in the development of epidermolysis bullosa.
This study reports a variant of ILNEB syndrome in two siblings differing from the previously reported patients in the lack of nephrotic impairment and survival beyond childhood; they are the first reported compound heterozygous for ITGA3 mutations.
Results provide evidence that alpha3 and alpha6 integrins have significantly different internalization kinetics and that coordination exists between them for internalization in prostate cancer cells.
Exposure to magnesium ions facilitated hBMSC proliferation via integrin alpha2 and alpha3 expression and partly promoted differentiation into osteoblasts via the alteration of ALP expression and activity
Our study elucidates the molecular mechanisms of miR-101/ITGA3 pathway in regulating nasopharyngeal carcinoma (NPC)metastasis and angiogenesis, and the systemic delivery of miR-101 provides a potent evidence for the development of a novel microRNA-targeting anticancer strategy for NPC patients.
findings identify a novel physiological context for combinatorial integrin signaling, laying the foundation for therapeutic strategies that manipulate alpha9beta1 and/or alpha3beta1 during wound healing
Results showed that ITGA3 was directly regulated by miR-199 family in head and neck squamous cell carcinoma cells (HNSCC). Its knockdown significantly inhibited cancer cell migration and invasion by HNSCC cells.
our studies clearly provide evidence that aberrant expression of sFRP2 can contribute to the invasive and metastatic potential for osteosarcoma.
Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 and ITGA2B), collagen ( COL5A1), and laminin ( LAMA5) were significantly inhibited by curcumin at messenger RNA and protein levels.
High ITGA3 expression is associated with bladder cancer.
Competition binding and infection experiments and biochemical assays pointed out alphaVbeta1 and alpha3beta1 to be of importance for human adenovirus-37 infection of corneal tissue.
The results suggested that podocyte detachment during early stage of diabetic nephropathy is mediated through upregulation of alpha3beta1-integrin.
these findings identify CD151 and its interactions with integrins a3 and a6 as potential therapeutic targets for inhibiting stemness-driving mechanisms and stem cell populations in Glioblastoma.
Expression of the alpha3-Integrin splice variants in the brain
the role of the CD151-alpha3beta1 complex in carcinoma progression is context dependent, and may depend on the mode of tumor cell invasion.
In high grade DCIS, when stratified according to the HER2 status, in the HER2-negative subgroup, CD151 assessed in combination with alpha3beta1 was significantly correlated with prognosis.
Data show that CD151 protein (CD151)-alpha3beta1 integrin complexes cooperated with epidermal growth factor receptor (EGFR) to drive tumor cell motility.
formation of CD151-integrin complex was likely to be a prerequisite for CD151-induced angiogenesis and signaling pathways
These results demonstrate multiple roles of integrin-alpha3 at the neuromuscular junction.
K63-linked polyubiquitination of Akt plays a previously unrecognized role in integrin alpha3beta1-dependent cell signaling required for ureteric bud development and may represent a novel mechanism whereby integrins regulate signaling pathways.
alpha3beta1-dependent alternative polyadenylation of MMP-9 mRNA occurs through a signaling pathway that involves extracellular signal-regulated kinase/mitogen-activated protein kinases.
NR1, a novel antioxidant, ameliorated glucose-induced impaired podocyte adhesive capacity and subsequent podocyte depopulation partly through a3b1 integrin upregulation.
This study reveals a previously unidentified role of laminin-111 in early stem cell differentiation.[Laminin-111]
These findings demonstrate a prominent role for alpha3beta1 in immortalized/transformed keratinocytes in regulating fibulin-2 and other genes that promote matrix remodeling and invasion.
Activation of signaling cascades downstream from alpha3beta1 integrin promotes prosurvival and proproliferative signals required for the malignant growth of basal mammary epithelial cells.
modest reductions in Integrin alpha3 function, as measured in in vitro assays, can have a substantial impact on metastatic behavior in vivo
integrin alpha3beta1 has a role in basement membrane stability through fibulin-2 induction, both in neonatal skin and in adult wounds
GPR56 functions together with alpha3beta1 integrin in regulating cerebral cortical development.
Results indicate that the basement membrane extract (BME) embedment of islets can up-regulate the expression of alpha3 integrin and its signal transduction, which may improve islet viability.
During myoblast fusion integrin alpha3 associates with integrin beta1 and ADAM12, and also CD9 and CD81.
overexpression of mesangial integrin alpha1 and podocyte vimentin and integrin alpha3 may be important features of glomerular Alport disease
In the absence of alpha3beta1, tumor initiation is dramatically decreased because of increased epidermal turnover, leading to a loss of 7,12-dimethylbenzanthracene-initiated label-retaining keratinocytes.
The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha3beta1
alpha3beta1 integrin-mediated stimulation of the Rac/PAK pathway is required for the inhibition of myosin light-chain kinase activity, permitting completion of the myoepithelial cell contraction/relaxation cycle and successful lactation.
We show that integrin alpha3beta1 is a positive regulator of endothelial-VEGF
The involvement of fibronectin/RGD-binding integrins including alpha3beta1 and alpha5beta1 as well as glycoprotein IIb in megakaryocyte-induced osteoblast proliferation, was examined.
analysis of its promoter activity
cathepsin L and alpha(3) integrin have roles in podocyte migration
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
CD49 antigen-like family member C
, VLA-3 subunit alpha
, antigen identified by monoclonal antibody J143
, galactoprotein B3
, integrin alpha-3
, very late activation protein 3 receptor, alpha-3 subunit
, integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
, integrin alpha 3 subunit
, Galactoprotein B3
, Integrin alpha-3
, integrin alpha 3
, integrin alpha-3-like
, VLA-3 alpha 3
, VLA-3 receptor, alpha 3 subunit