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Human Monoclonal FOLR1 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4899886
Kelemen, Brenton, Parkinson, C Whitaker, Piskorz, Csizmadi, Robson: Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women. in PLoS ONE 2014
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Cow (Bovine) Monoclonal FOLR1 Primary Antibody for ELISA - ABIN253769
Jones, Nixon: Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein. in The Journal of nutrition 2002
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Human Polyclonal FOLR1 Primary Antibody for CyTOF, FACS - ABIN4899887
Rudman, Josephs, Cambrook, Karagiannis, Gilbert, Dodev, Hunt, Koers, Montes, Taams, Canevari, Figini, Blower, Beavil, Nicodemus, Corrigan, Kaye, Nestle, Gould, Spicer, Karagiannis et al.: Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I ... in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011
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Human Monoclonal FOLR1 Primary Antibody for FACS - ABIN4896856
Ando, Nagata, Nihira, Suzuki, Kanda, Adachi, Kubota, Kameyama, Nakano, Ando, Yamano, Ishii, Nakai, Nakamura: Potent Therapeutic Activity Against Peritoneal Dissemination and Malignant Ascites by the Novel Anti-Folate Receptor Alpha Antibody KHK2805. in Translational oncology 2017
Cow (Bovine) Polyclonal FOLR1 Primary Antibody for IHC, WB - ABIN2776804
Iwakiri, Sonobe, Nagai, Hirata, Wada, Miyahara: Expression status of folate receptor alpha is significantly correlated with prognosis in non-small-cell lung cancers. in Annals of surgical oncology 2008
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Human Polyclonal FOLR1 Primary Antibody for FACS, IHC - ABIN5664249
Li, Yang, Zhou, Zhong, Huang: Doxorubicin-loaded, charge reversible, folate modified HPMA copolymer conjugates for active cancer cell targeting. in Biomaterials 2014
Cow (Bovine) Polyclonal FOLR1 Primary Antibody for IP, ELISA - ABIN99372
Kameyama, Motoyama, Tanaka, Yamashita, Higashi, Arima: Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin. in International journal of nanomedicine 2017
Study report the expression of both FR-alpha and FR-beta on CD138 + plasma cells isolated from patients with multiple myeloma and the up-regulation of both FR-alpha and FR-beta expression after exposure to all-trans retinoic acid in two model myeloma cell lines.
This study demonstrated a new approach using a combination of EpCAM and FRalpha as CTC-capture targets to increase the sensitivity of CTC detection in NSCLC efficiently, specifically, and quickly.
Several experimental studies in mice and human epidemiological and genetics studies have suggested that FOLR1 abnormalities are involved in a portion of human neural tube defects (NTD), although the solo defect of FOLR1 did not cause NTD. (Review)
that FOLR1 is highly expressed in ovarian cancer but is reduced following multidrug resistance. FOLR1 may be a useful biomarker for ovarian cancer, and it may be useful as a therapeutic application to improve sensitivity to cisplatin treatment
mTORC1 or mTORC2 silencing markedly decreases the plasma membrane expression of FR-alpha and RFC transporter isoforms without affecting global protein expression
High Folate Receptor Alpha Expression Is Associated With Increased Risk of Recurrence in Triple-negative Breast Cancer.
The expression of folate receptor 1 (FOLR1) was significantly higher and occurred with higher frequency in metastatic lymph node samples from patients with advanced lung cancer.
We identified eight novel variants in SLC19A1 and twelve novel variants in FOLR1, FOLR2, and FOLR3. Pathogenic variants include c.1265delG in SLC19A1 resulting in an early stop codon, four large insertion deletion variants in FOLR3, and a stop_gain variant in FOLR3
In this study, folate receptor alpha (FRa)-targeted nano-liposomes (FLP) were designed to enhance the anti-tumor effect by targeting delivery of exogenous PEDF gene to cervical cancer cells..These results clearly showed that FLP were desired carriers for PEDF gene and FLP/PEDF might represent a potential novel strategy for gene therapy of cervical cancer.
Data show that higher folate receptor alpha (FRalpha) expression is predictive of a favorable prognosis in pancreatic ductal adenocarcinoma (PDAC) and FRalpha may represent a promising target for treatments.
our results demonstrate the substantial therapeutic potential of novel 6-substituted pyrrolo[2,3-d]pyrimidine antifolates with dual targeting of PCFT and FRalpha toward Epithelial ovarian cancer that express a range of FRalpha, along with PCFT, as well as cisplatin resistance
Low expression level of FOLR1 is associated with neuroendocrine lung tumors.
FolR1 is a predictive candidate and a therapeutic target for medulloblastoma.
Folr1 is a favorable target for fluorescence-guided surgery as tumor specific agent EC17 produced a clear fluorescent signal in ovarian and breast cancer tissue.
The Folate receptor alpha is associated with the progression of cervical cancer and regulates cervical cancer cells growth through phosphorylating ERK1/2, c-Fos, and c-Jun, which are key factors of the ERK signaling pathway.
Folate receptor alpha protein was expressed in the majority of lung adenocarcinomas and a minority of lung squamous cell carcinomas. Folate receptor alpha protein expression correlated with histologic grade for lung adenocarcinomas, and the greatest difference was observed between grade 1 and grade 3.
The present study shows the efficacy of silencing HuR in lung cancer cells using folate-conjugated nanoparticle system that is directed towards folate receptor-alpha overexpressing cancer cells.
This new protocol opens an effective way through synthesis and design of novel fluorescent nano-conjugates for FR expression investigation in tumor cells via targeted imaging, showing great potential in drug delivery mechanism study and cancer therapy
Suppression of FOLR1 by RNA interference altered gene expression profile of taxol-resistant nasopharyngeal carcinoma cells. Apoptosis-related genes, gene alterations in viral carcinogenesis/MAPK pathways may be important for taxol resistance reversal.
we confirmed the similarities between epithelial ovarian cancer and fallopian tube, normal and adenocarcinoma using FOLR1, FOLR2, CD68 and CD11b markers
These findings support a model in which the folate receptor interacts with cell adhesion molecules, thus regulating the apical cell membrane remodeling and cytoskeletal dynamics necessary for neural plate folding.
This study presented the disintegration of folate from bovine FOLR1 during high temperature processing.
FOLR1 is a key regulatory point of folate metabolism for milk protein synthesis within mammary epithelial cells.
Results show that the gene zgc:165502 is an orthologue of human Folate Receptor 1 located on chromosome 15 and is expressed globally during cleavage and gastrulation.
Midbrain dopamine neural progenitors and nascent dopamine neurons specifically express Folr1.
The above showed that human FRalpha based DNA vaccination with CpG oligodeoxynucleotides as an adjuvant was effective in growth inhibition of a FRalpha expressing tumor in mice and deserves further evaluation as a possible immunotherapy
Folate receptor alpha upregulates Oct4, Sox2 and Klf4 and downregulates miR-138 and miR-let-7 in cranial neural crest cells.
not detected in oocytes
Folate receptor expression on murine and human adipose tissue macrophages
Quantitative RT-PCR showed that Slc19a1 mRNA was expressed in mouse cumulus-oocyte complexes (COCs) and oocytes, whereas Folr1 showed expression only in preimplantation embryos, increasing from the 2-cell stage onward.
under conditions of reduced folate (Folr-/-) signalling, pathways crucial for proper development of the neural tube are significantly altered.
Nesting of T helper cell epitopes results in recruitment of latent pools of naive high-affinity/avidity folate receptor (FR)alpha-specific T cells, which have the ability to home to tumors expressing FRalpha and to reduce tumor burden.
Fbp1 has a role in anterior neural tube closure
Neural and orofacial defects are associated with Folbp1 knockout mice
Expression of genes in the anterior neural tube of gestational day 9 Folbp1-/- embryos
Has a prominent role in mediating susceptibility to heart defects.
folbp1 is essential for normal renal tubular folate reabsorption, preventing excessive urinary folate loss
Folbp1 regulates apoptosis and cell proliferation that underlies the aberrant neural tube and craniofacial defects
Abnormal heart looping was observed during early development of Folr1(-/-) embryos partially rescued by maternal folinic acid supplementation.
folate receptor type beta is induced in a bone marrow engraftment model of acute myelogenous leukemia
Folr1 gene ablation and abnormal folate homeostasis altered gene expression in developing heart and conotruncal tissues
These findings findings suggest that FRalpha plays a role in pituitary tumor formation, and this effect may in part be due to its regulation of the NOTCH3 pathway.
FOLR1 is a target for regulation by HNF4-alpha in visceral endoderm.
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
, KB cells FBP
, adult folate-binding protein
, folate binding protein
, folate receptor alpha
, folate receptor, adult
, ovarian tumor-associated antigen MOv18
, erythroid-specific folate receptor
, membrane-bound folate binding protein
, folate receptor 1 (adult)
, Folate receptor alpha
, folate binding protein 1
, folate-binding protein 1