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anti-Human GIPC1 Antibodies:
anti-Mouse (Murine) GIPC1 Antibodies:
anti-Rat (Rattus) GIPC1 Antibodies:
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Human Polyclonal GIPC1 Primary Antibody for IHC (p), IHC - ABIN250102
Wu, Haruta, Wei: GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion. in The Journal of biological chemistry 2010
Show all 2 Pubmed References
Upregulated expression of GIPC1 is associated with glioma.
Drd3 (show DRD3 Antibodies) palmitoylation acts as a molecular switch for Drd3 (show DRD3 Antibodies)-biased signaling via a GIPC1-dependent route, which is likely to affect the mode of action of antipsychotic drugs.
The composite biomarker, CAPG (show NCAPG Antibodies) and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment.
GIPC status determines the loading of cellular cargo in the exosome in pancreatic cancer cells.
GIPC binds LPA(1 (show LPAR1 Antibodies)) and promotes its trafficking from APPL (show APPL1 Antibodies)-containing signaling endosomes to EEA1 (show EEA1 Antibodies) early endosomes and thus attenuates LPA (show APOA Antibodies)-mediated Akt (show AKT1 Antibodies) signaling from APPL (show APPL1 Antibodies) endosomes.
Our results do not show a predictive or prognostic function of GIPC1/Synectin expression for the outcome of radiotherapy in prostate cancer.
a novel non-Smad (show SMAD1 Antibodies) function for endoglin (show ENG Antibodies) and GIPC in regulating endothelial cell function during angiogenesis
The placental lectins reduced the binding of IGF-I (show IGF1 Antibodies) to IGF-1 (show IGF1 Antibodies) receptor in a dose-dependent manner.
Knockdown of ADRM1 (show Adrm1 Antibodies) in amplified ovarian cell-line OAW42 results in downregulation of growth factor GIPC1 and upregulation of tumor-suppressor RECK (show RECK Antibodies) RNA and protein
GIPC1 plays an essential role in oncogenic transformation, and its expression is necessary for the survival of human breast and colorectal cancer cells
Silencing of gipc1 in tadpoles caused lymphatic defects due to an underdevelopment and impaired migration of Prox-1(+) lymphatic endothelial cells.
Results indicate that kermit 2/XGIPC is a novel component of the IGF pathway, potentially functioning through modulation of the IGF1 (show IGF1 Antibodies) receptor.
Morpholino knockdown of synectin in zebrafish impaired formation of the thoracic duct, due to selective defects in lymphangiogenic but not angiogenic sprouting.
GIPC1 forms a domain-swapped dimer in an autoinhibited conformation that hinders binding of both PlexinD1 and myosin VI (show MYO6 Antibodies). PlexinD1 binding to GIPC1 releases the autoinhibition, promoting its interaction with myosin VI (show MYO6 Antibodies). GIPCs and myosin VI (show MYO6 Antibodies) interact through two distinct interfaces and form an open-ended alternating array.
Down-regulation of endogenous GIPC1 is sufficient to inhibit the development of eye field cells from embryonic stem cells.
Higher ratios of PSD-95 (show DLG4 Antibodies)/GluN2B (show GRIN2B Antibodies) and GAIP-interacting protein C (show PROC Antibodies)-terminus (GIPC)/GluN2B (show GRIN2B Antibodies) were associated with poorer learning index scores across all ages.
findings identify Gipc1 as a new interactor for Vangl2 (show VANGL2 Antibodies); show that a myosin VI (show MYO6 Antibodies)-Gipc1 protein complex can regulate Vangl2 (show VANGL2 Antibodies) traffic in heterologous cells; results indicate a broad role for Gipc1 in the development of both stereociliary bundles and cell polarization
TGFbetaR3 interaction with GIPC1 is critical for regulating invasion and growth factor responsiveness in epicardial cells, and dysregulation of epicardial cell proliferation and invasion contributes to failed coronary vessel development in Tgfbr3 (show TGFBR3 Antibodies)(-/-) mice
GIPC1-MyoGEF (show PLEKHG6 Antibodies) complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.
Synectin is widely distributed in adult cells and tissues, and in the embryo apparent at day 4.5, peaks at day 12.5 and declines by day 18.5, and may be involved in mediation of outside-in signaling.
Synectin selectively regulates arterial branching morphogenesis.
Results define an important role for the Myo6 (show MYO6 Antibodies)-GIPC1 motor complex in presynaptic function and in BDNF (show BDNF Antibodies)-TrkB (show NTRK2 Antibodies)-mediated synaptic plasticity.
a prototypical GIPC/synectin-binding receptor, revealed that deletion of its PDZ (show INADL Antibodies)-binding motif drastically reduced GIPC/synectin and myosin VI (show MYO6 Antibodies) recruitment to endocytic vesicles
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008
GAIP C-terminus-interacting protein
, GLUT1 C-terminal binding protein
, IGF-1 receptor interacting protein 1
, PDZ domain-containing protein GIPC1
, RGS-GAIP-interacting protein
, RGS19-interacting protein 1
, regulator of G-protein signalling 19 interacting protein 1
, tax interaction protein 2
, developmental regulator
, PDZ domain-containing protein
, regulator of G-protein signaling 19-interacting protein 1
, GIPC PDZ domain containing family, member 1
, GIPC PDZ domain containing family, member 3
, RGS-GAIP interacting protein GIPC
, Tax interacting protein, clone 2
, regulator of G-protein signaling 19 interacting protein 1
, semaF cytoplasmic domain associated protein
, semaF cytoplasmic domain-associated protein 1
, GLUT1 C-terminal-binding protein
, RGS-GAIP interacting protein C-terminus
, RGS-GAIP interacting protein, C-terminus
, rgs-gaip interacting protein gipc