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anti-Human Podoplanin Antibodies:
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Mouse (Murine) Monoclonal Podoplanin Primary Antibody for CyTOF, EM - ABIN269295
Katakai, Hara, Sugai, Gonda, Shimizu: Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. in The Journal of experimental medicine 2004
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Human Monoclonal Podoplanin Primary Antibody for FACS, IHC (fro) - ABIN115144
Birke, Lütjen-Drecoll, Kerjaschki, Birke: Expression of podoplanin and other lymphatic markers in the human anterior eye segment. in Investigative ophthalmology & visual science 2010
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Mouse (Murine) Monoclonal Podoplanin Primary Antibody for IHC (fro), IHC (p) - ABIN115147
Gohda, Kunisawa, Miura, Kagiyama, Kurashima, Higuchi, Ishikawa, Ogahara, Kiyono: Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Human Monoclonal Podoplanin Primary Antibody for FACS, IHC (fro) - ABIN115146
Breiteneder-Geleff, Matsui, Soleiman, Meraner, Poczewski, Kalt, Schaffner, Kerjaschki: Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis. in The American journal of pathology 1997
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Human Monoclonal Podoplanin Primary Antibody for IHC - ABIN1003029
Breiteneder-Geleff, Soleiman, Kowalski, Horvat, Amann, Kriehuber, Diem, Weninger, Tschachler, Alitalo, Kerjaschki: Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. in The American journal of pathology 1999
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Human Polyclonal Podoplanin Primary Antibody for CyTOF, FACS - ABIN4899549
Volk-Draper, Hall, Wilber, Ran: Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4. in PLoS ONE 2017
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Human Polyclonal Podoplanin Primary Antibody for FM, IP - ABIN1003032
Zimmer, Oeffner, Von Messling, Tschernig, Gröness, Klenk, Herrler: Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. in The Biochemical journal 1999
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Human Monoclonal Podoplanin Primary Antibody for IHC (fro), IHC (p) - ABIN2476175
Schweisfurth, Köhler: [Diagnostic basic program in pneumological services: current conditions--a retrospective analysis. Work Group of administrative hospital physicians of pneumological services]. in Pneumologie (Stuttgart, Germany) 1992
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Mouse (Murine) Monoclonal Podoplanin Primary Antibody for IHC (fro), IHC (p) - ABIN155169
DAmico, Jones, Nye, Sapienza, Ramjuan, Reynolds, Robinson, Kostourou, Martinez, Aubyn, Grose, Thomas, Spencer-Dene, Zicha, Davies, Tybulewicz, Hodivala-Dilke: Regulation of lymphatic-blood vessel separation by endothelial Rac1. in Development (Cambridge, England) 2009
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Human Monoclonal Podoplanin Primary Antibody for FACS - ABIN155160
Conrad, Niess, Huss, Huber, von Luettichau, Nelson, Ott, Jauch, Bruns: Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo. in Circulation 2009
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Podoplanin+ fibroblast infiltration significantly decreased overall survival (OS) and disease-free survival in all types of solid tumors. In stratified analyses, podoplanin+ fibroblast infiltration was significantly associated with worse OS in cholangiocarcinoma, breast, lung and pancreatic cancer.
Studied expression of podoplanin in placentas of normotensive and preeclamtic women with and without HIV infections using immunohistochemistry.
Our results suggest that podoplanin expression by cancer associated fibroblasts could predict poor patient outcome in breast carcinoma
The mRNA high expression levels of both podoplanin and LYVE-1 genes had a statistically significantly higher rate of LN metastasis (p<0.01) and histological grade (p<0.01 for podoplanin, p<0.05 for LYVE-1).
It participates in tumorigenesis of odontogenic t umors.
expression as a predictive marker of dysplasia in oral leukoplakia
Lymphatic vessels were identified by the expression of podoplanin
Study provided evidence that high clonal expansion capacity of podoplanin-positive tumor initiating cells populations was the result of reduced cell death by podoplanin-mediated signaling.
TGF-beta release from platelets is necessary for podoplanin-mediated tumor invasion and metastasis in lung cancer.
this study suggests that podoplanin can be used as a prognostic marker to determine the malignant potential in oral leukoplakias
High PDPN expression is associated with Inflammatory Rheumatoid Synovial Tissues.
Podoplanin expression in cancer-associated fibroblasts could be an independent predictor of increased risk of recurrence in patients with p-stage IA lung adenocarcinoma.
Studies found that PDPN is expressed by many types of tumor cells and cancer associated fibroblasts. Moreover, high levels of PDPN expression is associated with reduced survival and cancer aggression. [review]
Gastric tumor cells revealed no expression of PDPN. However, PDPN was expressed in some cases in spindle-shaped stromal cells within the tumor microenvironment, except for lymphatic vessels. PDPN expression was detected in neither tumor cells nor stromal cells of metastatic regions, such as lymph node and peritoneal metastases.
PDPN contributes to the malignant potential of hepatocellular carcinoma.
In lung adenocarcinoma, the presence of podoplanin-positive cancer-associated fibroblasts (CAFs) was associated with higher numbers of single nucleotide variants (SNVs) in cancer cells.
The prevalence of Oct-3/4 and D2-40-(podoplanin) positive staining of germ cells in testicular biopsies of boys with cryptorchidism were in age groups less than 6 months, 100% and 50%; 6-12 months, 60% and 17%; and 1-2 years, 12% and 4%. In all cases, the Oct-3/4 and D2-40 positive germ cells turned negative and the histological pattern normalized completely with age.
The presence of podoplanin expression in peritumoral keratinocytes correlates with aggressive behavior in extramammary Paget's disease (EMPD).
PDPN was induced by hypoxia and its overexpression undergoes a reduction of adhesion, making it an anti-adhesion molecule in the absence of CCL21, in the tumor.
Review of C-type lectin-like receptor 2 and podoplanin interactions [review]
mouse podoplanin initiates the formation of stable platelet aggregates at high shear. We speculate that this is important during the development of the mouse cerebrovasculature triggered by podoplanin on neuroepithelial cells and represents a specialized form of hemostasis.
Results suggest podoplanin-CLEC-2 as a novel anti-inflammatory axis regulating immune cell recruitment and activation in sepsis.
study uncovers a role for Pdpn in mammary SC function and, importantly, identifies Pdpn as a new regulator of Wnt/beta-catenin signaling, a key pathway in mammary development and tumorigenesis.
these data suggest that the platelet CLEC-2-podoplanin signaling axis regulates the severity of lung inflammation in mice and is a possible novel target for therapeutic intervention in patients at risk of developing ARDS.
Describe a bone-specific conditional Pdpn hypomorphic knockout mouse and confirm a role for Pdpn in the attainment of fully elongated osteocyte dendrites.
In podoplanin conditional knockout mice (Wnt1-Cre;PdpnDelta/Deltamice), the tooth and alveolar bone showed no morphological abnormalities and grow normally, indicating that podoplanin is not critical in the development of the tooth and bone.
Podoplanin expressed by lymphatic vessels prevents postnatal blood filling of the lymphatic vascular system and contributes to efficient dendritic cell migration to the lymph nodes.
Study provides evidence that podoplanin as a novel component of the neuronal machinery underlying neuritogenesis, synaptic plasticity, and hippocampus-dependent memory functions.
This study suggests that ppGalNAc-T13 contributes to neuronal differentiation through glycosylating and stabilizing PDPN, which provides insights into the regulatory roles of O-glycosylation in mammalian neural development.
Data show that E11/glycoprotein 38(GP38) was up-regulated upon SEMA3A stimulation, and cyclin-dependent kinase 6 (CDK6) was down-regulated in a time-dependent manner.
this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8-dependent crosstalk among VEGF-C, podoplanin and integrin pathways plays a key role.
A reciprocal interaction between CLEC-2 on megakaryocytes and PDPN on Bone marrow (BM) Fibroblastic reticular cell-like cells contributes to the periarteriolar megakaryopoietic microenvironment in mouse BM.
Data indicate that a mechanism reliant upon blockade of proteasome-mediated E11 destabilization contributes to osteocytogenesis and that this may involve downstream targeting of RhoA.
it is likely that PDPN, while being dispensable during re-epithelialization, has a crucial role in migration and invasion of transformed keratinocytes.
Report distinct podoplanin-positive stromal cell populations and a novel progenitor subset in chronic liver inflammation and fibrosis.
CLEC-2 is an adhesive receptor that supports platelet arrest to podoplanin under venous shear. Src/Syk-dependent signalling stabilises platelet adhesion to podoplanin.
Alternative NF-kappaB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction.
These results provide new insight into PDPN phosphorylation dynamics and the role of PDPN in cell motility.
Podoplanin and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels.
These results indicated that PDPN gene plays a significant role in the proliferation and maturation of bovine Sertoli cells.
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified.
, PA2.26 antigen
, glycoprotein 36
, glycoprotein, 36-KD
, lung type I cell membrane associated glycoprotein
, lung type-I cell membrane-associated glycoprotein (T1A-2)
, glycoprotein 38
, transmembrane glycoprotein E11
, E11 antigen epitope
, epithelial cell surface transmembrane protein antigen
, pulmonary type I alveolar epithelial cell transmembrane differentiation marker
, type I cell 40 kDa protein
, mucin-type membrane protein gp40