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Human Polyclonal ERCC5 Primary Antibody for ICC, IF - ABIN261688
Wang, Han, Milum, Wani: Stem cell protein Piwil2 modulates chromatin modifications upon cisplatin treatment. in Mutation research 2011
Show all 2 Pubmed References
ERCC5 rs17655 polymorphism may be not associated with overall head and neck cancer (HNC) risk. In a subgroup meta-analysis, the results suggest that the ERCC5 rs17655 polymorphism is probably associated with HNC risk in European, but the results should be interpreted with caution for the low number of studies. [meta-analysis]
Xeroderma pigmentosum group G gene rs2094258 polymorphism may be associated with an increased risk of gastric cancer in Southern China (Meta-Analysis)
For XPG rs17655, our results showed that the SNP was not associated with the risk of preeclampsia.
This meta-analysis indicates that the XPG rs751402 polymorphism may be a risk factor for gastric cancer in the Chinese population.
There is a multifarious interaction between the DNA repair gene ERCC5 SNPs (rs2094258 and rs873601) and the metabolic gene GSTP1 rs1695, which may form the basis for various inter-individual susceptibilities to atrophic gastritis in Chinese population.
this meta-analysis shows that XPG gene polymorphisms are associated with lung cancer and gastric cancer
Relevant SNPs in DNA repair (ERCC1 and ERCC5) and apoptosis (MDM2 and TP53) genes might influence the severity of radiation-related side-effects in HNSCC patients. Prospective clinical SNP-based validation studies are needed on these bases
Nine case-control studies involving 3540 cases and 3953 controls were included in the meta-analysis, which revealed that the XPG rs751402 polymorphism is positively associated with GC risk and could be viewed as a risk factor of GC in three genetic models. The XPG gene rs751402 polymorphism is associated with an increased risk of GC in Chinese Han populations. This fi nding should be veri fi ed by larger studies.
In NBEC, T allele at SNP rs2296147 upregulates ERCC5.
XPG gene polymorphism rs751402 was associated with increased susceptibility to gastric cancer in Chinese populations (Meta-Analysis)
Overexpression of human XPG and FEN1 increases genome instability in U2OS cells
This study showed that XPG rs2296147 CT/TT variants conferred significant survival disadvantage in CRC patients in term of PFS.
These results indicated that none of the selected XPG polymorphism could significantly alter gastric cancer susceptibility alone.
meta-analysis suggested that the rs873601 polymorphism was significantly associated with overall cancer risk. The moderate effects of rs751402 and rs2296147 polymorphism on cancer susceptibility might be highly dependent on cancer type and ethnicity, respectively
XPG mRNA expression was not predictive of trabectedin efficacy as single agent in hormone-positive, HER-2-negative advanced breast cancer.
the XPG gene rs2094258 C>T polymorphism may contribute to neuroblastoma susceptibility.
No strong evidence was found to support the use of XPG polymorphisms as tumor response and prognostic factors of patients with NSCLC receiving a platinum-based treatment regimen--(REVIEW)
Xpg thus helps to adequately induce DNA damage responses after IR, thereby keeping the expansion of damaged cells under control. This represents a new function of Xpg in the response to IR, in addition to its well-characterized role in nucleotide excision repair.
Meta-analysis indicated that the ERCC1 rs3212986 polymorphism and 2 polymorphisms in ERCC2 gene (rs13181 and rs1799793) contributed to the susceptibility of glioma. However, no association was observed between glioma risk and ERCC1 rs11615, ERCC2 rs238406, and ERCC5 rs17655 polymorphisms.
The rs751402 C/T SNP T allele and the T/T genotype were associated with an increased risk of GCA in younger individuals (>61 years) (odds ratio [OR] = 1.33 and 1.77, 95% confidence interval [CI] = 1.00-1.76 and 1.12-3.30, respectively). The rs873601 G/A SNP was not associated with susceptibility to GCA.
HIghlighted in this study is the crucial role of XPG's interactions with TFIIH for proper nucleotide excision repair
XPG gene expression can be influenced by an epigenetic mechanism. Restoration of NER activity through XPG gene transfer or treatment with demethylating agents restored sensitivity to nemorubicin.
introduced a point mutation into the XPG gene which inactivates the nuclease catalytic site but leaves the remainder of the protein intact. The mutant mice are hypersensitive to UV irradiation.
Results suggest that the Cockayne syndrome phenotype results from C-terminal truncations in the XPG (xeroderma pigmentosum) gene in mice and humans.
deficiency of exon 15 results in severe growth retardation and short life span
This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
DNA repair protein complementing XP-G cells
, excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome))
, DNA excision repair protein ERCC-5
, XPG-complementing protein
, xeroderma pigmentosum, complementation group G
, DNA repair protein complementing XP-G cells homolog
, DNA-repair protein complementing XP-G cells homolog
, XP-G related factor
, xeroderma pigmentosum group G-complementing protein homolog