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anti-Human MBD4 Antibodies:
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Human Polyclonal MBD4 Primary Antibody for WB - ABIN1881532
Arora, Lindgren, Basu, Nagaraj, Gross, Weisdorf, Thyagarajan: Polymorphisms in the base excision repair pathway and graft-versus-host disease. in Leukemia 2010
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Human Polyclonal MBD4 Primary Antibody for WB - ABIN4332947
Thatcher, Peddada, Yasui, Lasalle: Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. in Human molecular genetics 2005
Show all 2 Pubmed References
Human Polyclonal MBD4 Primary Antibody for ICC, IF - ABIN4332938
Kristensen, Nielsen, Jørgensen, Skakkebæk, Rajpert-De Meyts, Almstrup: Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis. in British journal of cancer 2014
Results demonstrated that MBD4 was downregulated, which lead to the overexpression and promoter hypomethylation of CD70 in CD4+ T cells from patients from systemic lupus erythematosus (SLE). This study preliminarily revealed the role and mechanism of MBD4 in the pathogenesis of SLE.
a novel molecular mechanism by which MBD4 inhibits GITR expression in a DNMT1-dependent manner
these data suggest that MBD4 inactivation may contribute to tumorigenesis, acting as a modifier of mismatch repair-deficient cancer phenotype.
MBD4 rs3138373 A>G and rs2005618 T>C single nucleotide polymorphisms were not associated with esophageal squamous cell carcinoma (ESCC) risk. rs3138355 GG genotype was associated with a decreased risk of ESCC among male patients and the elderly.
The ability of MBD4 to directly interact with and recruit USP7 to chromocenters implicates it as an additional factor that can potentially regulate Dnmt1 activity during cell proliferation.
Interaction between DNMT1 and MBD4 is involved in controlling gene expression and responding to oxidative stress.
ERCC4 rs1800124 and MBD4 rs10342 non-synonymous single nucleotide polymorphism variants were associated with DNA repair capacity.
the crystal structure of MBD4 bound to 5-hydroxymethylcytosine further demonstrates that MBDMBD4 is able to recognize a wide range of 5-methylcytosine modifications
MBD4 Glu346Lys polymorphism is associated with the risk of cervical cancer in a Chinese population.
Crystal structures of human MBD4(catalytic domain) reveal that MBD4 uses a base flipping mechanism to specifically recognize thymine and 5-hydroxymethyluracil.
specificity of MBD4 for acting at CpG sites depends largely on its methyl-CpG-binding domain, which binds preferably to G.T mispairs in a methylated CpG site
MBD4-8666 and MBD4-9229, but not MBD4-1057, gene polymorphisms are related to rheumatoid arthritis in Chinese patients in Taiwan.
MBD 4--a potential substrate for protein kinase X
the crystal structure of C-terminal glycosylase domain of human MBD4 was determined.
decreased expression in patients with primary immune thrombocytopenia
Data suggest that methyl-CpG binding domain 4 polymorphism may not be a stratification marker to predict the susceptibility to immune thrombocytopenic purpura, at least in the Chinese population.
MBD4 expression is associated with grade of malignancy in gliomas
results indicate the formation of a complex with the estradiol receptor
Frameshift mutations were found in 29% of gastric and 20% of colon MSI-H cancers, but not in any low-frequency microsatellite instability/microsatellite stable cancers.
MBD4 mutations were found in 15% MSI but not in MSS colrectal tumors.
Mbd4-/- mice displayed more severe symptoms, decreased survival, and a greater tumor burden than wild-type (WT) controls.
Mbd4 is a component of mismatch repair-directed DNA end processing.
A variant Mbd4 transcript spanning exons 1,6-8 is expressed in Mbd4 deficient B cells.
suppresses CpG mutability and tumorigenesis in vivo
studies indicate that, although inactivation of Mbd4 does not by itself cause cancer predisposition in mice, it can alter the mutation spectrum in cancer cells and modify the cancer predisposition phenotype
structure and activity of the mismatch-specific thymine glycosylase domain of MBD4
Mbd4 glycosylase does not significantly contribute to mechanisms of antibody diversification, as analyzed by an in vitro switch assay and by in vivo immunizations in Mbd4-/- knockout mice.
results establish a novel functional role for MBD4 in the cellular response to DNA damage and may have implications for its role in suppressing neoplasia
MED1 has a role in cell cycle arrest and apoptosis induced by DNA damage
in the context of MMR deficiency, additional loss of Mbd4 does not alter spontaneous mutation frequency at the endogenous Dlb-1b locus, nor does it modify tumour onset, tumour spectrum or MSI
Med1 depleted cells exhibited an exacerbated response to retinoids, both in terms transcriptional responses and of cellular differentiation.
Acts as a pivotal coactivator for GATA-1 in erythroid development.
Data report the characterization of interactions between Dnmt3b and both thymine-DNA glycosylase (Tdg) and methyl-CpG binding domain protein 4.
Studies on a complex A mutant mouse, defective for the Ift122 gene, is reported.
G/T mismatch glycosylse. Acts to maintain levels of 5-methylcytosine in the genome by initiating repair of the results of deamination of 5-methylcytosine
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, G/5-fluorouracil mismatch glycosylase with biphasic kinetics
, G/T mismatch glycosylase
, G/U mismatch glycosylase
, methyl-CpG-binding domain protein 4
, methyl-CpG-binding endonuclease 1
, methyl-CpG-binding protein MBD4
, mismatch-specific DNA N-glycosylase
, putative methyl-CpG binding protein