Browse our MCM4 Proteins (MCM4)

Full name:: Minichromosome Maintenance Deficient 4 Proteins (MCM4)

On www.antibodies-online.com are 6 Minichromosome Maintenance Deficient 4 (MCM4) Proteins from 3 different suppliers available. Additionally we are shipping MCM4 Antibodies (115) and MCM4 Kits (3) and many more products for this protein. A total of 141 MCM4 products are currently listed.

Synonyms:: 19G, AI325074, AU045576, cb1025, Cdc21, CDC54, fc12c09, fj85g09, hCdc21, hm:zeh1616, mcdc21, Mcmd4, mKIAA4003, NKCD, NKGCD, P1-CDC21, wu:fc12c09, wu:fj85g09, zeh1616

list all proteins	Gene Name	GeneID	UniProt
	MCM4	4173	P33991
Rat MCM4	MCM4	29728
	MCM4	17217	P49717
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MCM4 Proteins (MCM4) by Origin

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Top referenced MCM4 Proteins

Human MCM4 Protein expressed in Wheat germ - ABIN1310553 : Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011 (PubMed)

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Human Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

MCM4 and MCM7 (show MCM7 Proteins) expression is significantly correlated with Ki-67 (show MKI67 Proteins), Bmi1 (show BMI1 Proteins), and cyclin E (show CCNE1 Proteins) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.
This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded.
We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin
Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase activities to the complex containing wild-type MCM4
Mutant p53 (show TP53 Proteins) depletion profoundly influenced PARP1 (show PARP1 Proteins) localization and increased the level of PCNA (show PCNA Proteins) and MCM4 proteins.
Of the total, the deregulation of several genes (CDK1 (show CDK1 Proteins), CDK2 (show CDK2 Proteins), CDK4 (show CDK4 Proteins), MCM2 (show MCM2 Proteins), MCM3 (show MCM3 Proteins), MCM4, EIF3a (show EIF6 Proteins) and RPN2 (show PSMD1 Proteins)) were potentially associated with disease development and progression.
Mcm2-7 (show MCM2 Proteins) loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells
point mutation of MCM4 perturbs proper interaction with MCM6 (show MCM6 Proteins) to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 (show MCM2 Proteins) complex
Mutations in MCM4/PRKDC (show PRKDC Proteins) represent a novel cause of DNA breakage and NK cell deficiency.

Mouse (Murine) Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

Together, these data support a model in which chromosomal abnormalities in Sdl mice result from the ability of MCM4(D573H) to incorporate into MCM complexes and render them inactive.
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells
partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency
MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency
role of subunits in DNA helicase acdtivity
Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.
MCM4 phosphorylation by Cdc7 (show CDC7 Proteins) kinase facilitates its interaction with Cdc45 (show CDC45 Proteins) on chromatin
Hypomorphic alleles of Mcm4 may increase breast cancer risk.
Loss of one allele of cdc2l (show CDK13 Proteins) genefacilitates carcinogen-induced skin carcinogenesis in vivo.
Mcm4(Chaos3) mutation appears to destabilize the MCM2-7 (show MCM2 Proteins) complex, causing impaired DNA replication and may have a causative role in cancer development.

MCM4 Protein Profile

Protein Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Alternative names and synonyms associated with MCM4

minichromosome maintenance complex component 4 (mcm4)
minichromosome maintenance complex component 4 (MCM4)
minichromosome maintenance complex component 4 (Mcm4)

19G protein
AI325074 protein
AU045576 protein
cb1025 protein
Cdc21 protein
CDC54 protein
fc12c09 protein
fj85g09 protein
hCdc21 protein
hm:zeh1616 protein
mcdc21 protein
Mcmd4 protein
mKIAA4003 protein
NKCD protein
NKGCD protein
P1-CDC21 protein
wu:fc12c09 protein
wu:fj85g09 protein
zeh1616 protein

Protein level used designations for MCM4

DNA replication licensing factor mcm4 , MCM4 minichromosome maintenance deficient 4 , minichromosome maintenance protein 4 , DNA replication licensing factor MCM4 , CDC21 homolog , homolog of S. pombe cell devision cycle 21 , minichromosome maintenance deficient 4 , mini chromosome maintenance deficient 4 homolog , minichromosome maintenance deficient 4 homolog , P1-CDC21

GENE ID	SPECIES
448137	Xenopus (Silurana) tropicalis
337598	Danio rerio
4173	Homo sapiens
426764	Gallus gallus
477871	Canis lupus familiaris
504367	Bos taurus
29728	Rattus norvegicus
17217	Mus musculus

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Show all Minichromosome Maintenance Deficient 4 Proteins (MCM4) with Pubmed References

Human Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

Mouse (Murine) Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

Protein Summary

Alternative names and synonyms associated with MCM4

Protein level used designations for MCM4